Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

Detalhes bibliográficos
Autor(a) principal: Moldovan,Zenovia
Data de Publicação: 2012
Outros Autores: Badea,Irinel Adriana, Bunaciu,Andrei A., Aboul-Enein,Hassan Y.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000800029
Resumo: A spectrophotometric method for the indirect determination of captopril (CP) in pharmaceutical formulations is proposed. The proposed procedure is based on the oxidation of captopril by potassium dichromate and the determination excess oxidant on the basis of its reaction with diphenylcarbazide (DPC). Under the optimum conditions, a good linear relationship (r = 0.9997) was obtained in the range of 0.08-3.5 µg mL-1. The assay limits of detection and quantitation were 0.024 and 0.08 µg mL-1, respectively. The results obtained for captopril determination in pharmaceuticals using the proposed method and those obtained with the US Pharmacopoeia method were in good agreement at the 95% confidence level.
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spelling Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazidecaptoprildiphenylcarbazidespectrophotometric determinationA spectrophotometric method for the indirect determination of captopril (CP) in pharmaceutical formulations is proposed. The proposed procedure is based on the oxidation of captopril by potassium dichromate and the determination excess oxidant on the basis of its reaction with diphenylcarbazide (DPC). Under the optimum conditions, a good linear relationship (r = 0.9997) was obtained in the range of 0.08-3.5 µg mL-1. The assay limits of detection and quantitation were 0.024 and 0.08 µg mL-1, respectively. The results obtained for captopril determination in pharmaceuticals using the proposed method and those obtained with the US Pharmacopoeia method were in good agreement at the 95% confidence level.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000800029Química Nova v.35 n.8 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012000800029info:eu-repo/semantics/openAccessMoldovan,ZenoviaBadea,Irinel AdrianaBunaciu,Andrei A.Aboul-Enein,Hassan Y.eng2012-09-04T00:00:00Zoai:scielo:S0100-40422012000800029Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2012-09-04T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide
title Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide
spellingShingle Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide
Moldovan,Zenovia
captopril
diphenylcarbazide
spectrophotometric determination
title_short Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide
title_full Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide
title_fullStr Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide
title_full_unstemmed Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide
title_sort Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide
author Moldovan,Zenovia
author_facet Moldovan,Zenovia
Badea,Irinel Adriana
Bunaciu,Andrei A.
Aboul-Enein,Hassan Y.
author_role author
author2 Badea,Irinel Adriana
Bunaciu,Andrei A.
Aboul-Enein,Hassan Y.
author2_role author
author
author
dc.contributor.author.fl_str_mv Moldovan,Zenovia
Badea,Irinel Adriana
Bunaciu,Andrei A.
Aboul-Enein,Hassan Y.
dc.subject.por.fl_str_mv captopril
diphenylcarbazide
spectrophotometric determination
topic captopril
diphenylcarbazide
spectrophotometric determination
description A spectrophotometric method for the indirect determination of captopril (CP) in pharmaceutical formulations is proposed. The proposed procedure is based on the oxidation of captopril by potassium dichromate and the determination excess oxidant on the basis of its reaction with diphenylcarbazide (DPC). Under the optimum conditions, a good linear relationship (r = 0.9997) was obtained in the range of 0.08-3.5 µg mL-1. The assay limits of detection and quantitation were 0.024 and 0.08 µg mL-1, respectively. The results obtained for captopril determination in pharmaceuticals using the proposed method and those obtained with the US Pharmacopoeia method were in good agreement at the 95% confidence level.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000800029
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000800029
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422012000800029
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.8 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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