Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Química Nova (Online) |
| Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000900010 |
Resumo: | This study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were obtained in solution, presenting 1:1 stoichiometry according to the phase solubility diagram. The highest association constants were obtained with RMβCD and SBβCD, being selected for attainment of solid state complexes. These were characterized using XRD, SEM and dissolution test. The data obtained suggest the formation of complexes and indicate that these may provide a promising alternative way of developing solid doses of drug with suitable biopharmaceutical properties. |
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Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrinsbenznidazoleChagas diseaseinclusion complex and dissolutionThis study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were obtained in solution, presenting 1:1 stoichiometry according to the phase solubility diagram. The highest association constants were obtained with RMβCD and SBβCD, being selected for attainment of solid state complexes. These were characterized using XRD, SEM and dissolution test. The data obtained suggest the formation of complexes and indicate that these may provide a promising alternative way of developing solid doses of drug with suitable biopharmaceutical properties.Sociedade Brasileira de Química2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000900010Química Nova v.34 n.9 2011reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422011000900010info:eu-repo/semantics/openAccessSobrinho,José Lamartine SoaresSoares,Mônica Felts de La RocaLabandeira,Juan Jose TorresAlves,Lariza Darlene SantosRolim Neto,Pedro Joséeng2011-11-16T00:00:00Zoai:scielo:S0100-40422011000900010Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-11-16T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
| dc.title.none.fl_str_mv |
Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins |
| title |
Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins |
| spellingShingle |
Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins Sobrinho,José Lamartine Soares benznidazole Chagas disease inclusion complex and dissolution |
| title_short |
Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins |
| title_full |
Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins |
| title_fullStr |
Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins |
| title_full_unstemmed |
Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins |
| title_sort |
Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins |
| author |
Sobrinho,José Lamartine Soares |
| author_facet |
Sobrinho,José Lamartine Soares Soares,Mônica Felts de La Roca Labandeira,Juan Jose Torres Alves,Lariza Darlene Santos Rolim Neto,Pedro José |
| author_role |
author |
| author2 |
Soares,Mônica Felts de La Roca Labandeira,Juan Jose Torres Alves,Lariza Darlene Santos Rolim Neto,Pedro José |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Sobrinho,José Lamartine Soares Soares,Mônica Felts de La Roca Labandeira,Juan Jose Torres Alves,Lariza Darlene Santos Rolim Neto,Pedro José |
| dc.subject.por.fl_str_mv |
benznidazole Chagas disease inclusion complex and dissolution |
| topic |
benznidazole Chagas disease inclusion complex and dissolution |
| description |
This study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were obtained in solution, presenting 1:1 stoichiometry according to the phase solubility diagram. The highest association constants were obtained with RMβCD and SBβCD, being selected for attainment of solid state complexes. These were characterized using XRD, SEM and dissolution test. The data obtained suggest the formation of complexes and indicate that these may provide a promising alternative way of developing solid doses of drug with suitable biopharmaceutical properties. |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011-09-01 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000900010 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000900010 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
10.1590/S0100-40422011000900010 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
text/html |
| dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
| publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
| dc.source.none.fl_str_mv |
Química Nova v.34 n.9 2011 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| instname_str |
Sociedade Brasileira de Química (SBQ) |
| instacron_str |
SBQ |
| institution |
SBQ |
| reponame_str |
Química Nova (Online) |
| collection |
Química Nova (Online) |
| repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
| repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
| _version_ |
1750318112688832512 |