Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets

Detalhes bibliográficos
Autor(a) principal: Soares,Mônica Felts de La Roca
Data de Publicação: 2010
Outros Autores: Soares Sobrinho,José Lamartine, Grangeiro Júnior,Severino, Silva,Keyla Emanuelle Ramos da, Alves,Lariza Darlene Santos, Rolim Neto,Pedro José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200042
Resumo: This work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and validated. The dissolution test and quantification method showed to be adequate for their purposes and could be applied for quality control of ornidazole coated tablets, since there is no official monograph.
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spelling Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tabletsornidazolequality controldissolution testThis work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and validated. The dissolution test and quantification method showed to be adequate for their purposes and could be applied for quality control of ornidazole coated tablets, since there is no official monograph.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200042Química Nova v.33 n.2 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000200042info:eu-repo/semantics/openAccessSoares,Mônica Felts de La RocaSoares Sobrinho,José LamartineGrangeiro Júnior,SeverinoSilva,Keyla Emanuelle Ramos daAlves,Lariza Darlene SantosRolim Neto,Pedro Joséeng2010-03-12T00:00:00Zoai:scielo:S0100-40422010000200042Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-03-12T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
title Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
spellingShingle Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
Soares,Mônica Felts de La Roca
ornidazole
quality control
dissolution test
title_short Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
title_full Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
title_fullStr Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
title_full_unstemmed Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
title_sort Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
author Soares,Mônica Felts de La Roca
author_facet Soares,Mônica Felts de La Roca
Soares Sobrinho,José Lamartine
Grangeiro Júnior,Severino
Silva,Keyla Emanuelle Ramos da
Alves,Lariza Darlene Santos
Rolim Neto,Pedro José
author_role author
author2 Soares Sobrinho,José Lamartine
Grangeiro Júnior,Severino
Silva,Keyla Emanuelle Ramos da
Alves,Lariza Darlene Santos
Rolim Neto,Pedro José
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Soares,Mônica Felts de La Roca
Soares Sobrinho,José Lamartine
Grangeiro Júnior,Severino
Silva,Keyla Emanuelle Ramos da
Alves,Lariza Darlene Santos
Rolim Neto,Pedro José
dc.subject.por.fl_str_mv ornidazole
quality control
dissolution test
topic ornidazole
quality control
dissolution test
description This work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and validated. The dissolution test and quantification method showed to be adequate for their purposes and could be applied for quality control of ornidazole coated tablets, since there is no official monograph.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200042
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200042
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422010000200042
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.33 n.2 2010
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
_version_ 1750318110320099328

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