Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200042 |
Resumo: | This work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and validated. The dissolution test and quantification method showed to be adequate for their purposes and could be applied for quality control of ornidazole coated tablets, since there is no official monograph. |
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Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tabletsornidazolequality controldissolution testThis work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and validated. The dissolution test and quantification method showed to be adequate for their purposes and could be applied for quality control of ornidazole coated tablets, since there is no official monograph.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200042Química Nova v.33 n.2 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000200042info:eu-repo/semantics/openAccessSoares,Mônica Felts de La RocaSoares Sobrinho,José LamartineGrangeiro Júnior,SeverinoSilva,Keyla Emanuelle Ramos daAlves,Lariza Darlene SantosRolim Neto,Pedro Joséeng2010-03-12T00:00:00Zoai:scielo:S0100-40422010000200042Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-03-12T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets |
title |
Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets |
spellingShingle |
Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets Soares,Mônica Felts de La Roca ornidazole quality control dissolution test |
title_short |
Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets |
title_full |
Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets |
title_fullStr |
Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets |
title_full_unstemmed |
Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets |
title_sort |
Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets |
author |
Soares,Mônica Felts de La Roca |
author_facet |
Soares,Mônica Felts de La Roca Soares Sobrinho,José Lamartine Grangeiro Júnior,Severino Silva,Keyla Emanuelle Ramos da Alves,Lariza Darlene Santos Rolim Neto,Pedro José |
author_role |
author |
author2 |
Soares Sobrinho,José Lamartine Grangeiro Júnior,Severino Silva,Keyla Emanuelle Ramos da Alves,Lariza Darlene Santos Rolim Neto,Pedro José |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Soares,Mônica Felts de La Roca Soares Sobrinho,José Lamartine Grangeiro Júnior,Severino Silva,Keyla Emanuelle Ramos da Alves,Lariza Darlene Santos Rolim Neto,Pedro José |
dc.subject.por.fl_str_mv |
ornidazole quality control dissolution test |
topic |
ornidazole quality control dissolution test |
description |
This work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and validated. The dissolution test and quantification method showed to be adequate for their purposes and could be applied for quality control of ornidazole coated tablets, since there is no official monograph. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200042 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200042 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-40422010000200042 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.33 n.2 2010 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318110320099328 |