Análise conformacional por cálculos teóricos da distinctina, peptídeo antimicrobiano isolado de anuros da espécie Phyllomedusa distincta
Main Author: | |
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Publication Date: | 2008 |
Other Authors: | , |
Format: | Article |
Language: | por |
Source: | Química Nova (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000400022 |
Summary: | Various studies demonstrate that different frog species produce distinct classes of biologically active peptides. These peptides can act as alternative agents against pathogenic bacteria and fungi by membrane permeability. Although studies have recently demonstrated that this process is utterly related to the secondary structure adopted by the peptide (in this case, the a-helical structure) when in contact with the bacterial membrane, the detailed mechanism is still unknown. In this work we describe a conformational analysis of distinctin, a heterodimeric peptide isolated from the skin of Phyllomedusa distincta, an anuran found in the Brazilian Atlantic Forest. The study yielded a stable geometry with a high content of the a-helical structure both in chains 1 and 2 of distinctin, showing strong interaction between them. |
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Análise conformacional por cálculos teóricos da distinctina, peptídeo antimicrobiano isolado de anuros da espécie Phyllomedusa distinctaPhyllomedusa distinctaantimicrobial peptideconformational analysisVarious studies demonstrate that different frog species produce distinct classes of biologically active peptides. These peptides can act as alternative agents against pathogenic bacteria and fungi by membrane permeability. Although studies have recently demonstrated that this process is utterly related to the secondary structure adopted by the peptide (in this case, the a-helical structure) when in contact with the bacterial membrane, the detailed mechanism is still unknown. In this work we describe a conformational analysis of distinctin, a heterodimeric peptide isolated from the skin of Phyllomedusa distincta, an anuran found in the Brazilian Atlantic Forest. The study yielded a stable geometry with a high content of the a-helical structure both in chains 1 and 2 of distinctin, showing strong interaction between them.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000400022Química Nova v.31 n.4 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000400022info:eu-repo/semantics/openAccessMunhoz,Victor H. de OliveiraAlcântara,Antônio F. de CarvalhoPiló-Veloso,Dorilapor2008-06-16T00:00:00Zoai:scielo:S0100-40422008000400022Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2008-06-16T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Análise conformacional por cálculos teóricos da distinctina, peptídeo antimicrobiano isolado de anuros da espécie Phyllomedusa distincta |
title |
Análise conformacional por cálculos teóricos da distinctina, peptídeo antimicrobiano isolado de anuros da espécie Phyllomedusa distincta |
spellingShingle |
Análise conformacional por cálculos teóricos da distinctina, peptídeo antimicrobiano isolado de anuros da espécie Phyllomedusa distincta Munhoz,Victor H. de Oliveira Phyllomedusa distincta antimicrobial peptide conformational analysis |
title_short |
Análise conformacional por cálculos teóricos da distinctina, peptídeo antimicrobiano isolado de anuros da espécie Phyllomedusa distincta |
title_full |
Análise conformacional por cálculos teóricos da distinctina, peptídeo antimicrobiano isolado de anuros da espécie Phyllomedusa distincta |
title_fullStr |
Análise conformacional por cálculos teóricos da distinctina, peptídeo antimicrobiano isolado de anuros da espécie Phyllomedusa distincta |
title_full_unstemmed |
Análise conformacional por cálculos teóricos da distinctina, peptídeo antimicrobiano isolado de anuros da espécie Phyllomedusa distincta |
title_sort |
Análise conformacional por cálculos teóricos da distinctina, peptídeo antimicrobiano isolado de anuros da espécie Phyllomedusa distincta |
author |
Munhoz,Victor H. de Oliveira |
author_facet |
Munhoz,Victor H. de Oliveira Alcântara,Antônio F. de Carvalho Piló-Veloso,Dorila |
author_role |
author |
author2 |
Alcântara,Antônio F. de Carvalho Piló-Veloso,Dorila |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Munhoz,Victor H. de Oliveira Alcântara,Antônio F. de Carvalho Piló-Veloso,Dorila |
dc.subject.por.fl_str_mv |
Phyllomedusa distincta antimicrobial peptide conformational analysis |
topic |
Phyllomedusa distincta antimicrobial peptide conformational analysis |
description |
Various studies demonstrate that different frog species produce distinct classes of biologically active peptides. These peptides can act as alternative agents against pathogenic bacteria and fungi by membrane permeability. Although studies have recently demonstrated that this process is utterly related to the secondary structure adopted by the peptide (in this case, the a-helical structure) when in contact with the bacterial membrane, the detailed mechanism is still unknown. In this work we describe a conformational analysis of distinctin, a heterodimeric peptide isolated from the skin of Phyllomedusa distincta, an anuran found in the Brazilian Atlantic Forest. The study yielded a stable geometry with a high content of the a-helical structure both in chains 1 and 2 of distinctin, showing strong interaction between them. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000400022 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000400022 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.1590/S0100-40422008000400022 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.31 n.4 2008 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318107607433216 |