Avanços recentes na síntese do Remdesivir, Molnupiravir (EIDD-2801) e Tenofovir: moléculas promissoras no tratamento da COVID-19
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000100053 |
Resumo: | RECENT ADVANCES IN THE SYNTHESIS OF REMDESIVIR, MOLNUPIRAVIR (EIDD-2801) AND TENOFOVIR: PROMISING MOLECULES IN THE TREATMENT OF COVID-19. The search for new treatments to contain the Covid-19 pandemic has highlighted the importance of nucleoside antivirals, such as Remdesivir, Tenofovir and Molnupiravir. Over the last two years, these molecules have been intensely investigated as promising alternatives against SARS-CoV-2 virus. Considering the increasingly demand for those substances, several research groups are intensely investigating synthetic developments in order to obtain these nucleoside derivatives and their intermediates in a fast, efficient and accessible manner. In this context, this review aims to in-depth present the recent advances concerning the preparation of Remdesivir, Tenofovir and Molnupiravir. Aspects involving differences in the starting materials and reagents, as well as the advantages and limitations of each protocol would be carefully disclosed. Moreover, the use of synthetic tools, such as flow chemistry, organocatalysis and biocatalysis, would also be detailed. Finally, this review also presents aspects involving the scale-up of these transformations, including discussions about stereo- and diastereoselectivity, as well as product isolation details. In summary, an overview of the existing synthetic strategies for these active pharmaceutical ingredients (APIs) are presented. |
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Avanços recentes na síntese do Remdesivir, Molnupiravir (EIDD-2801) e Tenofovir: moléculas promissoras no tratamento da COVID-19nucleosideCovid-19antiviralremdesivirRECENT ADVANCES IN THE SYNTHESIS OF REMDESIVIR, MOLNUPIRAVIR (EIDD-2801) AND TENOFOVIR: PROMISING MOLECULES IN THE TREATMENT OF COVID-19. The search for new treatments to contain the Covid-19 pandemic has highlighted the importance of nucleoside antivirals, such as Remdesivir, Tenofovir and Molnupiravir. Over the last two years, these molecules have been intensely investigated as promising alternatives against SARS-CoV-2 virus. Considering the increasingly demand for those substances, several research groups are intensely investigating synthetic developments in order to obtain these nucleoside derivatives and their intermediates in a fast, efficient and accessible manner. In this context, this review aims to in-depth present the recent advances concerning the preparation of Remdesivir, Tenofovir and Molnupiravir. Aspects involving differences in the starting materials and reagents, as well as the advantages and limitations of each protocol would be carefully disclosed. Moreover, the use of synthetic tools, such as flow chemistry, organocatalysis and biocatalysis, would also be detailed. Finally, this review also presents aspects involving the scale-up of these transformations, including discussions about stereo- and diastereoselectivity, as well as product isolation details. In summary, an overview of the existing synthetic strategies for these active pharmaceutical ingredients (APIs) are presented.Sociedade Brasileira de Química2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000100053Química Nova v.45 n.1 2022reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170803info:eu-repo/semantics/openAccessBraga,Taniris CSantos,Juliana A. dosCastro,Pedro P. deAmarante,Giovanni Wpor2022-03-07T00:00:00Zoai:scielo:S0100-40422022000100053Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2022-03-07T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Avanços recentes na síntese do Remdesivir, Molnupiravir (EIDD-2801) e Tenofovir: moléculas promissoras no tratamento da COVID-19 |
title |
Avanços recentes na síntese do Remdesivir, Molnupiravir (EIDD-2801) e Tenofovir: moléculas promissoras no tratamento da COVID-19 |
spellingShingle |
Avanços recentes na síntese do Remdesivir, Molnupiravir (EIDD-2801) e Tenofovir: moléculas promissoras no tratamento da COVID-19 Braga,Taniris C nucleoside Covid-19 antiviral remdesivir |
title_short |
Avanços recentes na síntese do Remdesivir, Molnupiravir (EIDD-2801) e Tenofovir: moléculas promissoras no tratamento da COVID-19 |
title_full |
Avanços recentes na síntese do Remdesivir, Molnupiravir (EIDD-2801) e Tenofovir: moléculas promissoras no tratamento da COVID-19 |
title_fullStr |
Avanços recentes na síntese do Remdesivir, Molnupiravir (EIDD-2801) e Tenofovir: moléculas promissoras no tratamento da COVID-19 |
title_full_unstemmed |
Avanços recentes na síntese do Remdesivir, Molnupiravir (EIDD-2801) e Tenofovir: moléculas promissoras no tratamento da COVID-19 |
title_sort |
Avanços recentes na síntese do Remdesivir, Molnupiravir (EIDD-2801) e Tenofovir: moléculas promissoras no tratamento da COVID-19 |
author |
Braga,Taniris C |
author_facet |
Braga,Taniris C Santos,Juliana A. dos Castro,Pedro P. de Amarante,Giovanni W |
author_role |
author |
author2 |
Santos,Juliana A. dos Castro,Pedro P. de Amarante,Giovanni W |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Braga,Taniris C Santos,Juliana A. dos Castro,Pedro P. de Amarante,Giovanni W |
dc.subject.por.fl_str_mv |
nucleoside Covid-19 antiviral remdesivir |
topic |
nucleoside Covid-19 antiviral remdesivir |
description |
RECENT ADVANCES IN THE SYNTHESIS OF REMDESIVIR, MOLNUPIRAVIR (EIDD-2801) AND TENOFOVIR: PROMISING MOLECULES IN THE TREATMENT OF COVID-19. The search for new treatments to contain the Covid-19 pandemic has highlighted the importance of nucleoside antivirals, such as Remdesivir, Tenofovir and Molnupiravir. Over the last two years, these molecules have been intensely investigated as promising alternatives against SARS-CoV-2 virus. Considering the increasingly demand for those substances, several research groups are intensely investigating synthetic developments in order to obtain these nucleoside derivatives and their intermediates in a fast, efficient and accessible manner. In this context, this review aims to in-depth present the recent advances concerning the preparation of Remdesivir, Tenofovir and Molnupiravir. Aspects involving differences in the starting materials and reagents, as well as the advantages and limitations of each protocol would be carefully disclosed. Moreover, the use of synthetic tools, such as flow chemistry, organocatalysis and biocatalysis, would also be detailed. Finally, this review also presents aspects involving the scale-up of these transformations, including discussions about stereo- and diastereoselectivity, as well as product isolation details. In summary, an overview of the existing synthetic strategies for these active pharmaceutical ingredients (APIs) are presented. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000100053 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000100053 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.21577/0100-4042.20170803 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.45 n.1 2022 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
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