Catalyzed and non-catalyzed synthesis of bioactive monastrol

Detalhes bibliográficos
Autor(a) principal: Alvim,Haline G. O.
Data de Publicação: 2014
Outros Autores: Correa,Jose R., Machado,Taynara R., Silva,Wender A., D. Neto,Brenno A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014001000022
Resumo: The bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions. The use of two Lewis acids (FeCl3 and CuCl2) and two Brønsted acids (HCl and CF3COOH) as catalysts improved the reaction yields of the transformation compared with the non-catalyzed reaction. The experiments investigated catalysis and its role, the importance of multicomponent reactions and their green features, and the application of these concepts to the synthesis of a biologically important structure.
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spelling Catalyzed and non-catalyzed synthesis of bioactive monastrolMonastrolBiginellimulticomponent reactioncatalysisThe bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions. The use of two Lewis acids (FeCl3 and CuCl2) and two Brønsted acids (HCl and CF3COOH) as catalysts improved the reaction yields of the transformation compared with the non-catalyzed reaction. The experiments investigated catalysis and its role, the importance of multicomponent reactions and their green features, and the application of these concepts to the synthesis of a biologically important structure.Sociedade Brasileira de Química2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014001000022Química Nova v.37 n.10 2014reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0100-4042.20140266info:eu-repo/semantics/openAccessAlvim,Haline G. O.Correa,Jose R.Machado,Taynara R.Silva,Wender A.D. Neto,Brenno A.eng2014-11-28T00:00:00Zoai:scielo:S0100-40422014001000022Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2014-11-28T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Catalyzed and non-catalyzed synthesis of bioactive monastrol
title Catalyzed and non-catalyzed synthesis of bioactive monastrol
spellingShingle Catalyzed and non-catalyzed synthesis of bioactive monastrol
Alvim,Haline G. O.
Monastrol
Biginelli
multicomponent reaction
catalysis
title_short Catalyzed and non-catalyzed synthesis of bioactive monastrol
title_full Catalyzed and non-catalyzed synthesis of bioactive monastrol
title_fullStr Catalyzed and non-catalyzed synthesis of bioactive monastrol
title_full_unstemmed Catalyzed and non-catalyzed synthesis of bioactive monastrol
title_sort Catalyzed and non-catalyzed synthesis of bioactive monastrol
author Alvim,Haline G. O.
author_facet Alvim,Haline G. O.
Correa,Jose R.
Machado,Taynara R.
Silva,Wender A.
D. Neto,Brenno A.
author_role author
author2 Correa,Jose R.
Machado,Taynara R.
Silva,Wender A.
D. Neto,Brenno A.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Alvim,Haline G. O.
Correa,Jose R.
Machado,Taynara R.
Silva,Wender A.
D. Neto,Brenno A.
dc.subject.por.fl_str_mv Monastrol
Biginelli
multicomponent reaction
catalysis
topic Monastrol
Biginelli
multicomponent reaction
catalysis
description The bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions. The use of two Lewis acids (FeCl3 and CuCl2) and two Brønsted acids (HCl and CF3COOH) as catalysts improved the reaction yields of the transformation compared with the non-catalyzed reaction. The experiments investigated catalysis and its role, the importance of multicomponent reactions and their green features, and the application of these concepts to the synthesis of a biologically important structure.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014001000022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014001000022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0100-4042.20140266
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.37 n.10 2014
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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