Caracterização físico-química do fármaco antichagásico benznidazol
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000800018 |
Resumo: | Currently, benznidazole (BNZ) is a unique therapeutic alternative available in Brazil to treat Chagas disease. Despite its traditional medical use, little is known about the chemical nature of this drug. A detailed study of the physicochemical properties of BNZ was performed using multiple assays. Thermal, diffractometric, morphological and reological drug profiles were obtained. The partition coefficient and solubility results allowed this drug to be classified as a class IV drug according to the biopharmaceutical classification system. This information will be useful for the development of more effective BNZ formulations and for establishing the quality profile of BNZ. |
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Caracterização físico-química do fármaco antichagásico benznidazolbenznidazolepreformulationbiopharmaceutical classificationCurrently, benznidazole (BNZ) is a unique therapeutic alternative available in Brazil to treat Chagas disease. Despite its traditional medical use, little is known about the chemical nature of this drug. A detailed study of the physicochemical properties of BNZ was performed using multiple assays. Thermal, diffractometric, morphological and reological drug profiles were obtained. The partition coefficient and solubility results allowed this drug to be classified as a class IV drug according to the biopharmaceutical classification system. This information will be useful for the development of more effective BNZ formulations and for establishing the quality profile of BNZ.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000800018Química Nova v.33 n.8 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000800018info:eu-repo/semantics/openAccessMaximiano,Flávia PiresCosta,Guilherme Hideki YoshizaneSouza,Jacqueline deCunha-Filho,Marcílio Sérgio Soares dapor2010-10-25T00:00:00Zoai:scielo:S0100-40422010000800018Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-10-25T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Caracterização físico-química do fármaco antichagásico benznidazol |
title |
Caracterização físico-química do fármaco antichagásico benznidazol |
spellingShingle |
Caracterização físico-química do fármaco antichagásico benznidazol Maximiano,Flávia Pires benznidazole preformulation biopharmaceutical classification |
title_short |
Caracterização físico-química do fármaco antichagásico benznidazol |
title_full |
Caracterização físico-química do fármaco antichagásico benznidazol |
title_fullStr |
Caracterização físico-química do fármaco antichagásico benznidazol |
title_full_unstemmed |
Caracterização físico-química do fármaco antichagásico benznidazol |
title_sort |
Caracterização físico-química do fármaco antichagásico benznidazol |
author |
Maximiano,Flávia Pires |
author_facet |
Maximiano,Flávia Pires Costa,Guilherme Hideki Yoshizane Souza,Jacqueline de Cunha-Filho,Marcílio Sérgio Soares da |
author_role |
author |
author2 |
Costa,Guilherme Hideki Yoshizane Souza,Jacqueline de Cunha-Filho,Marcílio Sérgio Soares da |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Maximiano,Flávia Pires Costa,Guilherme Hideki Yoshizane Souza,Jacqueline de Cunha-Filho,Marcílio Sérgio Soares da |
dc.subject.por.fl_str_mv |
benznidazole preformulation biopharmaceutical classification |
topic |
benznidazole preformulation biopharmaceutical classification |
description |
Currently, benznidazole (BNZ) is a unique therapeutic alternative available in Brazil to treat Chagas disease. Despite its traditional medical use, little is known about the chemical nature of this drug. A detailed study of the physicochemical properties of BNZ was performed using multiple assays. Thermal, diffractometric, morphological and reological drug profiles were obtained. The partition coefficient and solubility results allowed this drug to be classified as a class IV drug according to the biopharmaceutical classification system. This information will be useful for the development of more effective BNZ formulations and for establishing the quality profile of BNZ. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000800018 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000800018 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.1590/S0100-40422010000800018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.33 n.8 2010 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318111142182912 |