Modelagem de proteínas por homologia
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Publication Date: | 2003 |
Other Authors: | |
Format: | Article |
Language: | por |
Source: | Química Nova (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000200019 |
Summary: | Modeling methods to derive 3D-structure of proteins have been recently developed. Protein homology-modeling, also known as comparative protein modeling, is nowadays the most accurate protein modeling method. This technique can produce useful models for about an order of magnitude more protein sequences than there have been structures determined by experiment in the same amount of time. All current protein homology-modeling methods consist of four sequential steps: fold assignment and template selection, template-target alignment, model building, and model evaluation. In this paper we discuss in some detail the protein-homology paradigm, its predictive power and its limitations. |
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Modelagem de proteínas por homologiaprotein structure predictionhomology modelingstructural biologyModeling methods to derive 3D-structure of proteins have been recently developed. Protein homology-modeling, also known as comparative protein modeling, is nowadays the most accurate protein modeling method. This technique can produce useful models for about an order of magnitude more protein sequences than there have been structures determined by experiment in the same amount of time. All current protein homology-modeling methods consist of four sequential steps: fold assignment and template selection, template-target alignment, model building, and model evaluation. In this paper we discuss in some detail the protein-homology paradigm, its predictive power and its limitations.Sociedade Brasileira de Química2003-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000200019Química Nova v.26 n.2 2003reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422003000200019info:eu-repo/semantics/openAccessSantos Filho,Osvaldo AndradeAlencastro,Ricardo Bicca depor2003-04-08T00:00:00Zoai:scielo:S0100-40422003000200019Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2003-04-08T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Modelagem de proteínas por homologia |
title |
Modelagem de proteínas por homologia |
spellingShingle |
Modelagem de proteínas por homologia Santos Filho,Osvaldo Andrade protein structure prediction homology modeling structural biology |
title_short |
Modelagem de proteínas por homologia |
title_full |
Modelagem de proteínas por homologia |
title_fullStr |
Modelagem de proteínas por homologia |
title_full_unstemmed |
Modelagem de proteínas por homologia |
title_sort |
Modelagem de proteínas por homologia |
author |
Santos Filho,Osvaldo Andrade |
author_facet |
Santos Filho,Osvaldo Andrade Alencastro,Ricardo Bicca de |
author_role |
author |
author2 |
Alencastro,Ricardo Bicca de |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Santos Filho,Osvaldo Andrade Alencastro,Ricardo Bicca de |
dc.subject.por.fl_str_mv |
protein structure prediction homology modeling structural biology |
topic |
protein structure prediction homology modeling structural biology |
description |
Modeling methods to derive 3D-structure of proteins have been recently developed. Protein homology-modeling, also known as comparative protein modeling, is nowadays the most accurate protein modeling method. This technique can produce useful models for about an order of magnitude more protein sequences than there have been structures determined by experiment in the same amount of time. All current protein homology-modeling methods consist of four sequential steps: fold assignment and template selection, template-target alignment, model building, and model evaluation. In this paper we discuss in some detail the protein-homology paradigm, its predictive power and its limitations. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000200019 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000200019 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.1590/S0100-40422003000200019 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.26 n.2 2003 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318103109042176 |