AVANÇOS RECENTES EM BIOSSÍNTESE COMBINATÓRIA DE POLICETÍDEOS: PERSPECTIVAS E DESAFIOS
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000100071 |
Resumo: | Natural products continue to inspire scientists on the search for biological active structures. Recent advances in synthetic biology allow modifying genes to extend structural diversity present on natural products by changing important functional groups guided through genetic information. In this context, polyketides synthases (PKS) represent a class of enzymes from where the first applications and well succeed modifications were achieved. During the last two decades PKSs have been extensively studied, sequenced and deposited in data banks available to scientific community around the world. This newly wide information associated to different methodologies accessible to modify the PKSs genetic circuits including genetic insertion, gene deletion and gene replacement leads to discovery of new natural products. In this review, the recent advances in combinatorial biosynthesis, as well as modern techniques in synthetic biology to promote structural diversity on natural products will be discussed. |
id |
SBQ-3_834aed734bd062968408fd921bd35e29 |
---|---|
oai_identifier_str |
oai:scielo:S0100-40422019000100071 |
network_acronym_str |
SBQ-3 |
network_name_str |
Química Nova (Online) |
repository_id_str |
|
spelling |
AVANÇOS RECENTES EM BIOSSÍNTESE COMBINATÓRIA DE POLICETÍDEOS: PERSPECTIVAS E DESAFIOSpolyketidescombinatorial biosynthesispolyketide synthasessynthetic biologyNatural products continue to inspire scientists on the search for biological active structures. Recent advances in synthetic biology allow modifying genes to extend structural diversity present on natural products by changing important functional groups guided through genetic information. In this context, polyketides synthases (PKS) represent a class of enzymes from where the first applications and well succeed modifications were achieved. During the last two decades PKSs have been extensively studied, sequenced and deposited in data banks available to scientific community around the world. This newly wide information associated to different methodologies accessible to modify the PKSs genetic circuits including genetic insertion, gene deletion and gene replacement leads to discovery of new natural products. In this review, the recent advances in combinatorial biosynthesis, as well as modern techniques in synthetic biology to promote structural diversity on natural products will be discussed.Sociedade Brasileira de Química2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000100071Química Nova v.42 n.1 2019reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170307info:eu-repo/semantics/openAccessPaulo,Bruno S.Sigrist,RenataOliveira,Luciana G. depor2019-02-20T00:00:00Zoai:scielo:S0100-40422019000100071Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2019-02-20T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
AVANÇOS RECENTES EM BIOSSÍNTESE COMBINATÓRIA DE POLICETÍDEOS: PERSPECTIVAS E DESAFIOS |
title |
AVANÇOS RECENTES EM BIOSSÍNTESE COMBINATÓRIA DE POLICETÍDEOS: PERSPECTIVAS E DESAFIOS |
spellingShingle |
AVANÇOS RECENTES EM BIOSSÍNTESE COMBINATÓRIA DE POLICETÍDEOS: PERSPECTIVAS E DESAFIOS Paulo,Bruno S. polyketides combinatorial biosynthesis polyketide synthases synthetic biology |
title_short |
AVANÇOS RECENTES EM BIOSSÍNTESE COMBINATÓRIA DE POLICETÍDEOS: PERSPECTIVAS E DESAFIOS |
title_full |
AVANÇOS RECENTES EM BIOSSÍNTESE COMBINATÓRIA DE POLICETÍDEOS: PERSPECTIVAS E DESAFIOS |
title_fullStr |
AVANÇOS RECENTES EM BIOSSÍNTESE COMBINATÓRIA DE POLICETÍDEOS: PERSPECTIVAS E DESAFIOS |
title_full_unstemmed |
AVANÇOS RECENTES EM BIOSSÍNTESE COMBINATÓRIA DE POLICETÍDEOS: PERSPECTIVAS E DESAFIOS |
title_sort |
AVANÇOS RECENTES EM BIOSSÍNTESE COMBINATÓRIA DE POLICETÍDEOS: PERSPECTIVAS E DESAFIOS |
author |
Paulo,Bruno S. |
author_facet |
Paulo,Bruno S. Sigrist,Renata Oliveira,Luciana G. de |
author_role |
author |
author2 |
Sigrist,Renata Oliveira,Luciana G. de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Paulo,Bruno S. Sigrist,Renata Oliveira,Luciana G. de |
dc.subject.por.fl_str_mv |
polyketides combinatorial biosynthesis polyketide synthases synthetic biology |
topic |
polyketides combinatorial biosynthesis polyketide synthases synthetic biology |
description |
Natural products continue to inspire scientists on the search for biological active structures. Recent advances in synthetic biology allow modifying genes to extend structural diversity present on natural products by changing important functional groups guided through genetic information. In this context, polyketides synthases (PKS) represent a class of enzymes from where the first applications and well succeed modifications were achieved. During the last two decades PKSs have been extensively studied, sequenced and deposited in data banks available to scientific community around the world. This newly wide information associated to different methodologies accessible to modify the PKSs genetic circuits including genetic insertion, gene deletion and gene replacement leads to discovery of new natural products. In this review, the recent advances in combinatorial biosynthesis, as well as modern techniques in synthetic biology to promote structural diversity on natural products will be discussed. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000100071 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000100071 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.21577/0100-4042.20170307 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.42 n.1 2019 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318119309541376 |