Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines

Detalhes bibliográficos
Autor(a) principal: Micheletti,Ana Camila
Data de Publicação: 2011
Outros Autores: Honda,Neli Kika, Lima,Dênis Pires de, Beatriz,Adilson, Sant'ana,Maria Rita, Carvalho,Nadia Cristina Pereira, Matos,Maria de Fatima Cepa, Queiróz,Lyara Meira Marinho, Bogo,Danielle, Zorzatto,José Roberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600019
Resumo: A series of 15 ω-aminoalkoxylxanthones containing methyl, ethyl, propyl, tert-butylamino and piperidinyl moieties were synthesized from a natural xanthone isolated from a lichen species. These compounds were tested for their in vitro antibacterial properties against Gram-positive and Gram-negative bacteria and cytotoxicity against a number of human tumor cell lines was too evaluated. The newly synthesized derivatives revealed selective activity against Staphylococcus aureus (Gram-positive), and the most promising results are for a multidrug resistant strain, for which six of these compounds showed good activity (MICs 4 µg/mL). Many derivatives inhibited tumor cells growth and most compounds were active on multiple lines.
id SBQ-3_ca0bd86eab72f15ec9bfc345b3a8b8b1
oai_identifier_str oai:scielo:S0100-40422011000600019
network_acronym_str SBQ-3
network_name_str Química Nova (Online)
repository_id_str
spelling Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell linesxanthoneantimicrobial activitycytotoxic activityA series of 15 ω-aminoalkoxylxanthones containing methyl, ethyl, propyl, tert-butylamino and piperidinyl moieties were synthesized from a natural xanthone isolated from a lichen species. These compounds were tested for their in vitro antibacterial properties against Gram-positive and Gram-negative bacteria and cytotoxicity against a number of human tumor cell lines was too evaluated. The newly synthesized derivatives revealed selective activity against Staphylococcus aureus (Gram-positive), and the most promising results are for a multidrug resistant strain, for which six of these compounds showed good activity (MICs 4 µg/mL). Many derivatives inhibited tumor cells growth and most compounds were active on multiple lines.Sociedade Brasileira de Química2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600019Química Nova v.34 n.6 2011reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422011000600019info:eu-repo/semantics/openAccessMicheletti,Ana CamilaHonda,Neli KikaLima,Dênis Pires deBeatriz,AdilsonSant'ana,Maria RitaCarvalho,Nadia Cristina PereiraMatos,Maria de Fatima CepaQueiróz,Lyara Meira MarinhoBogo,DanielleZorzatto,José Robertoeng2011-08-01T00:00:00Zoai:scielo:S0100-40422011000600019Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-08-01T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines
title Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines
spellingShingle Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines
Micheletti,Ana Camila
xanthone
antimicrobial activity
cytotoxic activity
title_short Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines
title_full Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines
title_fullStr Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines
title_full_unstemmed Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines
title_sort Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines
author Micheletti,Ana Camila
author_facet Micheletti,Ana Camila
Honda,Neli Kika
Lima,Dênis Pires de
Beatriz,Adilson
Sant'ana,Maria Rita
Carvalho,Nadia Cristina Pereira
Matos,Maria de Fatima Cepa
Queiróz,Lyara Meira Marinho
Bogo,Danielle
Zorzatto,José Roberto
author_role author
author2 Honda,Neli Kika
Lima,Dênis Pires de
Beatriz,Adilson
Sant'ana,Maria Rita
Carvalho,Nadia Cristina Pereira
Matos,Maria de Fatima Cepa
Queiróz,Lyara Meira Marinho
Bogo,Danielle
Zorzatto,José Roberto
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Micheletti,Ana Camila
Honda,Neli Kika
Lima,Dênis Pires de
Beatriz,Adilson
Sant'ana,Maria Rita
Carvalho,Nadia Cristina Pereira
Matos,Maria de Fatima Cepa
Queiróz,Lyara Meira Marinho
Bogo,Danielle
Zorzatto,José Roberto
dc.subject.por.fl_str_mv xanthone
antimicrobial activity
cytotoxic activity
topic xanthone
antimicrobial activity
cytotoxic activity
description A series of 15 ω-aminoalkoxylxanthones containing methyl, ethyl, propyl, tert-butylamino and piperidinyl moieties were synthesized from a natural xanthone isolated from a lichen species. These compounds were tested for their in vitro antibacterial properties against Gram-positive and Gram-negative bacteria and cytotoxicity against a number of human tumor cell lines was too evaluated. The newly synthesized derivatives revealed selective activity against Staphylococcus aureus (Gram-positive), and the most promising results are for a multidrug resistant strain, for which six of these compounds showed good activity (MICs 4 µg/mL). Many derivatives inhibited tumor cells growth and most compounds were active on multiple lines.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422011000600019
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.34 n.6 2011
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
_version_ 1750318112322879488

Registros relacionados