Spectrophotometric determination of famotidine using sulphonphthalein dyes

Detalhes bibliográficos
Autor(a) principal: Basavaiah,Kanakapura
Data de Publicação: 2011
Outros Autores: Zenita,Okram
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000500002
Resumo: Four new extraction-free spectrophotometric methods have been established for the quantitation of famotidine (FMT). The methods are based on the formation of yellow ion-pair complexes between FMT and four sulphonphthalein dyes viz., bromothymol blue (method A), bromophenol blue (method B), bromocresol purple (method C) and bromocresol green (method D) in dioxane or acetone medium. The experimental variables such as reagent concentration, solvent medium and reaction time have been carefully optimized to achieve the highest sensitivity. The proposed methods were applied successfully to the determination of famotidine in tablets with good accuracy and precision and without interferences from common excipients. The results obtained by the proposed methods were compared favorably with those of the reference method.
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spelling Spectrophotometric determination of famotidine using sulphonphthalein dyesfamotidine assayspectrophotometrytabletsFour new extraction-free spectrophotometric methods have been established for the quantitation of famotidine (FMT). The methods are based on the formation of yellow ion-pair complexes between FMT and four sulphonphthalein dyes viz., bromothymol blue (method A), bromophenol blue (method B), bromocresol purple (method C) and bromocresol green (method D) in dioxane or acetone medium. The experimental variables such as reagent concentration, solvent medium and reaction time have been carefully optimized to achieve the highest sensitivity. The proposed methods were applied successfully to the determination of famotidine in tablets with good accuracy and precision and without interferences from common excipients. The results obtained by the proposed methods were compared favorably with those of the reference method.Sociedade Brasileira de Química2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000500002Química Nova v.34 n.5 2011reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422011000500002info:eu-repo/semantics/openAccessBasavaiah,KanakapuraZenita,Okrameng2011-07-18T00:00:00Zoai:scielo:S0100-40422011000500002Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-07-18T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Spectrophotometric determination of famotidine using sulphonphthalein dyes
title Spectrophotometric determination of famotidine using sulphonphthalein dyes
spellingShingle Spectrophotometric determination of famotidine using sulphonphthalein dyes
Basavaiah,Kanakapura
famotidine assay
spectrophotometry
tablets
title_short Spectrophotometric determination of famotidine using sulphonphthalein dyes
title_full Spectrophotometric determination of famotidine using sulphonphthalein dyes
title_fullStr Spectrophotometric determination of famotidine using sulphonphthalein dyes
title_full_unstemmed Spectrophotometric determination of famotidine using sulphonphthalein dyes
title_sort Spectrophotometric determination of famotidine using sulphonphthalein dyes
author Basavaiah,Kanakapura
author_facet Basavaiah,Kanakapura
Zenita,Okram
author_role author
author2 Zenita,Okram
author2_role author
dc.contributor.author.fl_str_mv Basavaiah,Kanakapura
Zenita,Okram
dc.subject.por.fl_str_mv famotidine assay
spectrophotometry
tablets
topic famotidine assay
spectrophotometry
tablets
description Four new extraction-free spectrophotometric methods have been established for the quantitation of famotidine (FMT). The methods are based on the formation of yellow ion-pair complexes between FMT and four sulphonphthalein dyes viz., bromothymol blue (method A), bromophenol blue (method B), bromocresol purple (method C) and bromocresol green (method D) in dioxane or acetone medium. The experimental variables such as reagent concentration, solvent medium and reaction time have been carefully optimized to achieve the highest sensitivity. The proposed methods were applied successfully to the determination of famotidine in tablets with good accuracy and precision and without interferences from common excipients. The results obtained by the proposed methods were compared favorably with those of the reference method.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000500002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000500002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422011000500002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.34 n.5 2011
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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