Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin

Detalhes bibliográficos
Autor(a) principal: Neves,Cláudia M. B.
Data de Publicação: 2012
Outros Autores: Simões,Mário M. Q., Domingues,Fernando M. J., Neves,M. Graça P. M. S., Cavaleiro,José A. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700033
Resumo: This laboratory project is planned for an undergraduate chemistry laboratory in which students prepare a manganese porphyrin able to mimic the oxidative metabolism of carbamazepine, one of the most frequently prescribed drugs in the treatment of epilepsy. The in vitro oxidation of carbamazepine results in the formation of the corresponding 10,11-epoxide, the main in vivo metabolite. The reaction is catalyzed by manganese porphyrin in the presence of H2O2, an environmentally-friendly oxidant. Through this project students will develop their skills in organic synthesis, coordination chemistry, chromatographic techniques such as TLC and HPLC, UV-visible spectrophotometry, and NMR spectroscopy.
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spelling Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrinMn(III) porphyrincatalysisepoxidationThis laboratory project is planned for an undergraduate chemistry laboratory in which students prepare a manganese porphyrin able to mimic the oxidative metabolism of carbamazepine, one of the most frequently prescribed drugs in the treatment of epilepsy. The in vitro oxidation of carbamazepine results in the formation of the corresponding 10,11-epoxide, the main in vivo metabolite. The reaction is catalyzed by manganese porphyrin in the presence of H2O2, an environmentally-friendly oxidant. Through this project students will develop their skills in organic synthesis, coordination chemistry, chromatographic techniques such as TLC and HPLC, UV-visible spectrophotometry, and NMR spectroscopy.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700033Química Nova v.35 n.7 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012000700033info:eu-repo/semantics/openAccessNeves,Cláudia M. B.Simões,Mário M. Q.Domingues,Fernando M. J.Neves,M. Graça P. M. S.Cavaleiro,José A. S.eng2012-08-16T00:00:00Zoai:scielo:S0100-40422012000700033Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2012-08-16T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
title Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
spellingShingle Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
Neves,Cláudia M. B.
Mn(III) porphyrin
catalysis
epoxidation
title_short Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
title_full Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
title_fullStr Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
title_full_unstemmed Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
title_sort Biomimetic oxidation of carbamazepine with hydrogen peroxide catalyzed by a manganese porphyrin
author Neves,Cláudia M. B.
author_facet Neves,Cláudia M. B.
Simões,Mário M. Q.
Domingues,Fernando M. J.
Neves,M. Graça P. M. S.
Cavaleiro,José A. S.
author_role author
author2 Simões,Mário M. Q.
Domingues,Fernando M. J.
Neves,M. Graça P. M. S.
Cavaleiro,José A. S.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Neves,Cláudia M. B.
Simões,Mário M. Q.
Domingues,Fernando M. J.
Neves,M. Graça P. M. S.
Cavaleiro,José A. S.
dc.subject.por.fl_str_mv Mn(III) porphyrin
catalysis
epoxidation
topic Mn(III) porphyrin
catalysis
epoxidation
description This laboratory project is planned for an undergraduate chemistry laboratory in which students prepare a manganese porphyrin able to mimic the oxidative metabolism of carbamazepine, one of the most frequently prescribed drugs in the treatment of epilepsy. The in vitro oxidation of carbamazepine results in the formation of the corresponding 10,11-epoxide, the main in vivo metabolite. The reaction is catalyzed by manganese porphyrin in the presence of H2O2, an environmentally-friendly oxidant. Through this project students will develop their skills in organic synthesis, coordination chemistry, chromatographic techniques such as TLC and HPLC, UV-visible spectrophotometry, and NMR spectroscopy.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700033
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700033
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422012000700033
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.7 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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