Oxidative stress in the bladder of men with LUTS undergoing open prostatectomy: a pilot study
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Braz J Urol (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000601182 |
Resumo: | ABSTRACT Purpose: This study aims to evaluate the link between preoperative parameters and oxidative stress (OS) markers in the bladder wall of men undergoing open prostatectomy. Materials and Methods: From July 2014 to August 2016, men aged ≥ 50 years and presenting with LUTS were prospectively enrolled. Preoperative assessment included validated questionnaires (IPSS and OAB - V8), lower urinary tract ultrasound and urodynamics. Bladder biopsies were taken during open prostatectomy for determination of OS markers. Increased OS was defined by increased concentration of malondialdehyde (MDA) and / or decreased concentration of antioxidant enzymes (superoxide dismutase and / or catalase). P<0.05 was regarded as statistically significant. Results: Thirty - eight consecutive patients were included. Mean age was 66.36 ± 6.44 years, mean prostate volume was 77.7 ± 20.63 cm3, and mean IPSS was 11.05 ± 8.72 points. MDA concentration was increased in men with severe bladder outlet obstruction (BOO grade V - VI according to the Schaefer's nomogram) in comparison with BOO grade III - IV (p = 0.022). Patients with severe LUTS also had higher MDA concentration when compared to those with mild LUTS (p = 0.031). There was a statistically significant association between increased post - void residual urine (cut off ≥ 50 mL) and not only higher levels of MDA, but also reduced activity of SOD and catalase (p < 0.05). Conclusions: This pilot study showed that severity of LUTS and BOO were associated with increased MDA concentration in the bladder wall of men undergoing open prostatectomy. Further studies are still needed to assess the role of non - invasive biomarkers of OS in predicting bladder dysfunction in men with LUTS. |
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Oxidative stress in the bladder of men with LUTS undergoing open prostatectomy: a pilot studyUrinary BladderLower Urinary Tract SymptomsUrinary Bladder Neck ObstructionOxidative StressABSTRACT Purpose: This study aims to evaluate the link between preoperative parameters and oxidative stress (OS) markers in the bladder wall of men undergoing open prostatectomy. Materials and Methods: From July 2014 to August 2016, men aged ≥ 50 years and presenting with LUTS were prospectively enrolled. Preoperative assessment included validated questionnaires (IPSS and OAB - V8), lower urinary tract ultrasound and urodynamics. Bladder biopsies were taken during open prostatectomy for determination of OS markers. Increased OS was defined by increased concentration of malondialdehyde (MDA) and / or decreased concentration of antioxidant enzymes (superoxide dismutase and / or catalase). P<0.05 was regarded as statistically significant. Results: Thirty - eight consecutive patients were included. Mean age was 66.36 ± 6.44 years, mean prostate volume was 77.7 ± 20.63 cm3, and mean IPSS was 11.05 ± 8.72 points. MDA concentration was increased in men with severe bladder outlet obstruction (BOO grade V - VI according to the Schaefer's nomogram) in comparison with BOO grade III - IV (p = 0.022). Patients with severe LUTS also had higher MDA concentration when compared to those with mild LUTS (p = 0.031). There was a statistically significant association between increased post - void residual urine (cut off ≥ 50 mL) and not only higher levels of MDA, but also reduced activity of SOD and catalase (p < 0.05). Conclusions: This pilot study showed that severity of LUTS and BOO were associated with increased MDA concentration in the bladder wall of men undergoing open prostatectomy. Further studies are still needed to assess the role of non - invasive biomarkers of OS in predicting bladder dysfunction in men with LUTS.Sociedade Brasileira de Urologia2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000601182International braz j urol v.44 n.6 2018reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/s1677-5538.ibju.2018.0127info:eu-repo/semantics/openAccessAverbeck,Marcio AugustoLima,Nelson Gianni deMotta,Gabriela AlmeidaBeltrão,LauroAbboud Filho,Nury JafarRigotti,Clarice PereiraSantos,William Nascimento dosSantos,Steven Kitzberger Jaeger dosSilva,Luis Fernando Batista daRhoden,Ernani Luiseng2019-01-03T00:00:00Zoai:scielo:S1677-55382018000601182Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2019-01-03T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false |
dc.title.none.fl_str_mv |
Oxidative stress in the bladder of men with LUTS undergoing open prostatectomy: a pilot study |
title |
Oxidative stress in the bladder of men with LUTS undergoing open prostatectomy: a pilot study |
spellingShingle |
Oxidative stress in the bladder of men with LUTS undergoing open prostatectomy: a pilot study Averbeck,Marcio Augusto Urinary Bladder Lower Urinary Tract Symptoms Urinary Bladder Neck Obstruction Oxidative Stress |
title_short |
Oxidative stress in the bladder of men with LUTS undergoing open prostatectomy: a pilot study |
title_full |
Oxidative stress in the bladder of men with LUTS undergoing open prostatectomy: a pilot study |
title_fullStr |
Oxidative stress in the bladder of men with LUTS undergoing open prostatectomy: a pilot study |
title_full_unstemmed |
Oxidative stress in the bladder of men with LUTS undergoing open prostatectomy: a pilot study |
title_sort |
Oxidative stress in the bladder of men with LUTS undergoing open prostatectomy: a pilot study |
author |
Averbeck,Marcio Augusto |
author_facet |
Averbeck,Marcio Augusto Lima,Nelson Gianni de Motta,Gabriela Almeida Beltrão,Lauro Abboud Filho,Nury Jafar Rigotti,Clarice Pereira Santos,William Nascimento dos Santos,Steven Kitzberger Jaeger dos Silva,Luis Fernando Batista da Rhoden,Ernani Luis |
author_role |
author |
author2 |
Lima,Nelson Gianni de Motta,Gabriela Almeida Beltrão,Lauro Abboud Filho,Nury Jafar Rigotti,Clarice Pereira Santos,William Nascimento dos Santos,Steven Kitzberger Jaeger dos Silva,Luis Fernando Batista da Rhoden,Ernani Luis |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Averbeck,Marcio Augusto Lima,Nelson Gianni de Motta,Gabriela Almeida Beltrão,Lauro Abboud Filho,Nury Jafar Rigotti,Clarice Pereira Santos,William Nascimento dos Santos,Steven Kitzberger Jaeger dos Silva,Luis Fernando Batista da Rhoden,Ernani Luis |
dc.subject.por.fl_str_mv |
Urinary Bladder Lower Urinary Tract Symptoms Urinary Bladder Neck Obstruction Oxidative Stress |
topic |
Urinary Bladder Lower Urinary Tract Symptoms Urinary Bladder Neck Obstruction Oxidative Stress |
description |
ABSTRACT Purpose: This study aims to evaluate the link between preoperative parameters and oxidative stress (OS) markers in the bladder wall of men undergoing open prostatectomy. Materials and Methods: From July 2014 to August 2016, men aged ≥ 50 years and presenting with LUTS were prospectively enrolled. Preoperative assessment included validated questionnaires (IPSS and OAB - V8), lower urinary tract ultrasound and urodynamics. Bladder biopsies were taken during open prostatectomy for determination of OS markers. Increased OS was defined by increased concentration of malondialdehyde (MDA) and / or decreased concentration of antioxidant enzymes (superoxide dismutase and / or catalase). P<0.05 was regarded as statistically significant. Results: Thirty - eight consecutive patients were included. Mean age was 66.36 ± 6.44 years, mean prostate volume was 77.7 ± 20.63 cm3, and mean IPSS was 11.05 ± 8.72 points. MDA concentration was increased in men with severe bladder outlet obstruction (BOO grade V - VI according to the Schaefer's nomogram) in comparison with BOO grade III - IV (p = 0.022). Patients with severe LUTS also had higher MDA concentration when compared to those with mild LUTS (p = 0.031). There was a statistically significant association between increased post - void residual urine (cut off ≥ 50 mL) and not only higher levels of MDA, but also reduced activity of SOD and catalase (p < 0.05). Conclusions: This pilot study showed that severity of LUTS and BOO were associated with increased MDA concentration in the bladder wall of men undergoing open prostatectomy. Further studies are still needed to assess the role of non - invasive biomarkers of OS in predicting bladder dysfunction in men with LUTS. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000601182 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000601182 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1677-5538.ibju.2018.0127 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
dc.source.none.fl_str_mv |
International braz j urol v.44 n.6 2018 reponame:International Braz J Urol (Online) instname:Sociedade Brasileira de Urologia (SBU) instacron:SBU |
instname_str |
Sociedade Brasileira de Urologia (SBU) |
instacron_str |
SBU |
institution |
SBU |
reponame_str |
International Braz J Urol (Online) |
collection |
International Braz J Urol (Online) |
repository.name.fl_str_mv |
International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU) |
repository.mail.fl_str_mv |
||brazjurol@brazjurol.com.br |
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1750318076419637248 |