Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Braz J Urol (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000400642 |
Resumo: | ABSTRACTPurpose:The aim of this study was to identify possible protein biomarkers and/or candidates for therapeutic targets in tissues of patients with SCCP, infected by HPV, applying one dimensional electrophoresis (1DE), followed by direct mass spectrometry (MS) analysis.Materials and Methods:Tissues from 10 HPV positive patients with SCCP and from 10 patients with HPV negative non-tumorous penile foreskins were analyzed applying 1D electrophoresis, followed by analysis with direct mass spectrometry (MS).Results:Sixty-three different proteins were identified in the first group and 50 in the second group. Recognition was possible for 28 proteins exclusively detected in Group 1 and 21 proteins presented only in Group 2.Conclusion:Some proteins in the first group are directly involved in the development of other types of cancer, and therefore, suitable for analysis. Complement C3 protein is a strong candidate for evaluating SCCP patients. |
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International Braz J Urol (Online) |
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Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirusCarcinomaSquamous CellPenisHuman papillomavirusABSTRACTPurpose:The aim of this study was to identify possible protein biomarkers and/or candidates for therapeutic targets in tissues of patients with SCCP, infected by HPV, applying one dimensional electrophoresis (1DE), followed by direct mass spectrometry (MS) analysis.Materials and Methods:Tissues from 10 HPV positive patients with SCCP and from 10 patients with HPV negative non-tumorous penile foreskins were analyzed applying 1D electrophoresis, followed by analysis with direct mass spectrometry (MS).Results:Sixty-three different proteins were identified in the first group and 50 in the second group. Recognition was possible for 28 proteins exclusively detected in Group 1 and 21 proteins presented only in Group 2.Conclusion:Some proteins in the first group are directly involved in the development of other types of cancer, and therefore, suitable for analysis. Complement C3 protein is a strong candidate for evaluating SCCP patients.Sociedade Brasileira de Urologia2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000400642International braz j urol v.41 n.4 2015reponame:International Braz J Urol (Online)instname:Sociedade Brasileira de Urologia (SBU)instacron:SBU10.1590/S1677-5538.IBJU.2014.0051info:eu-repo/semantics/openAccessKoifman,LeandroOrnellas,PauloOrnellas,Antonio AugustoPereira,Denise de AbreuZingali,Benedeta RussolinaCavalcanti,Silvia Maria BaetaAfonso,Larissa AlvesSandim,VanessaAlves,Gildaeng2015-10-13T00:00:00Zoai:scielo:S1677-55382015000400642Revistahttp://www.brazjurol.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||brazjurol@brazjurol.com.br1677-61191677-5538opendoar:2015-10-13T00:00International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU)false |
dc.title.none.fl_str_mv |
Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus |
title |
Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus |
spellingShingle |
Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus Koifman,Leandro Carcinoma Squamous Cell Penis Human papillomavirus |
title_short |
Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus |
title_full |
Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus |
title_fullStr |
Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus |
title_full_unstemmed |
Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus |
title_sort |
Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus |
author |
Koifman,Leandro |
author_facet |
Koifman,Leandro Ornellas,Paulo Ornellas,Antonio Augusto Pereira,Denise de Abreu Zingali,Benedeta Russolina Cavalcanti,Silvia Maria Baeta Afonso,Larissa Alves Sandim,Vanessa Alves,Gilda |
author_role |
author |
author2 |
Ornellas,Paulo Ornellas,Antonio Augusto Pereira,Denise de Abreu Zingali,Benedeta Russolina Cavalcanti,Silvia Maria Baeta Afonso,Larissa Alves Sandim,Vanessa Alves,Gilda |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Koifman,Leandro Ornellas,Paulo Ornellas,Antonio Augusto Pereira,Denise de Abreu Zingali,Benedeta Russolina Cavalcanti,Silvia Maria Baeta Afonso,Larissa Alves Sandim,Vanessa Alves,Gilda |
dc.subject.por.fl_str_mv |
Carcinoma Squamous Cell Penis Human papillomavirus |
topic |
Carcinoma Squamous Cell Penis Human papillomavirus |
description |
ABSTRACTPurpose:The aim of this study was to identify possible protein biomarkers and/or candidates for therapeutic targets in tissues of patients with SCCP, infected by HPV, applying one dimensional electrophoresis (1DE), followed by direct mass spectrometry (MS) analysis.Materials and Methods:Tissues from 10 HPV positive patients with SCCP and from 10 patients with HPV negative non-tumorous penile foreskins were analyzed applying 1D electrophoresis, followed by analysis with direct mass spectrometry (MS).Results:Sixty-three different proteins were identified in the first group and 50 in the second group. Recognition was possible for 28 proteins exclusively detected in Group 1 and 21 proteins presented only in Group 2.Conclusion:Some proteins in the first group are directly involved in the development of other types of cancer, and therefore, suitable for analysis. Complement C3 protein is a strong candidate for evaluating SCCP patients. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000400642 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000400642 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1677-5538.IBJU.2014.0051 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
dc.source.none.fl_str_mv |
International braz j urol v.41 n.4 2015 reponame:International Braz J Urol (Online) instname:Sociedade Brasileira de Urologia (SBU) instacron:SBU |
instname_str |
Sociedade Brasileira de Urologia (SBU) |
instacron_str |
SBU |
institution |
SBU |
reponame_str |
International Braz J Urol (Online) |
collection |
International Braz J Urol (Online) |
repository.name.fl_str_mv |
International Braz J Urol (Online) - Sociedade Brasileira de Urologia (SBU) |
repository.mail.fl_str_mv |
||brazjurol@brazjurol.com.br |
_version_ |
1750318074158907392 |