Determinação de pesticidas organoclorados e fármacos em matrizes ambientais utilizando QuEChERS, extração líquido-líquido (LLE) e extração em fase sólida (SPE)
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFSCAR |
Texto Completo: | https://repositorio.ufscar.br/handle/ufscar/15588 |
Resumo: | The presence of xenobiotic organic contaminants in water bodies, where arrive from releases of treated or untreated effluent, has raised concerns about impacts related to the richness and biodiversity of aquatic life and human health. Considering the possibility of the increasing presence, persistence, and pseudo-persistence of pesticide and drugs in the environment and possible deleterious effect resulting from it, the objective of this work was to develop and to validate a multi-residue method using QuEChERS and Liquid-Liquid Extraction (LLE), for determination of organochlorine compounds (Aldrin, heptachlor, heptachlor epoxide, endosulfan (α and β), endosulfan sulfate, 4,4'-DEE, dieldrim, endrin, 4,4'-DDD, 4,4'-DDT, endrin aldehyde, Methoxychlor and hexachlorocyclohexane (α-BHC, β-BHC, γ-BHC e δ-BHC)) in soil, sediment, and freshwater, with gas chromatography-tandem electron capture detector (GC/ECD) and Solid Phase Extraction (SPE) for drugs quantification (Carbamazepine, Atenolol, Propranolol, CBZ-DiOH, Caffeine, Naproxen, Ibuprofen, 2-Hydroxycarbamazepine, Estrone, 17-β-estradiol, 17-α-ethinylestradiol, Paracetamol, 2-Hydroxy-ibuprofen and Diclofenac) in freshwater using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), in the collected sample in the regions of Hydrographic Sub-Basin of Ribeirão do Feijão and Hydrographic Sub-Basin of Rio Quilombo, in São Carlos, SP. The proposed method for organochlorine compounds determination was valid for all matrices. For solid samples, the analyte recoveries (%Rec) were between 50% and 117%, with a coefficient of variation (%CV) below 19 and linear correlation coefficient (R2) greater than 0.98, for all analytes. The value of matrix effect (ME) was between -8.73% for α-BHC and 585.35% for endrin. The limit of detection (LOD) was 0.759 µg Kg-1 for 4,4’-DDD and 2.144 µg Kg-1 for endosulfan sulfate, and the limit of quantification (LOQ) was between 2.528 µg Kg-1 and 7.147 µg Kg-1 , for the same analytes. The %Rec was between 40% and 144% for the freshwater sample, with %CV below 24 for 16 analytes analyzed. All R2 was greater than 0.99. The LOD ranged from 1.641 ng L-1 for α-BHC to 4.433 ng L-1 for endosulfan sulfate, while the LOQ was 5.473 ng L-1 and 14.779 ng L-1 for the same analytes. The ME was -13.73% for α-BHC and 393.43% for endrin. Regarding the determination of drugs in freshwater, the %Rec ranges from 93% to 120%, with %CV below ten and R2 greater than 0.98 for all analytes. The values of LOD ranged from 2.885 ng L-1 for ibuprofen to 5.293 ng L-1 for 17-β-estradiol, while the values of LOQ ranged from 9.618 ng L-1 to 17.642 ng L-1, for the same analytes. Regarding collected samples, the analysis performed to the determination of organochlorine compounds showed results below LOD. This was observed for the three matrices in all collect performed. In the analysis for drugs determination, the presence of ten analytes was observed. The caffeine was in all analyzed samples, with concentrations 105.2, 54.9, 52.3, and 184.4 ng L-1. The other analytes determined were atenolol (52.8, 28.3 and 17.2 ng L-1), carbamazepine (22.8, 17.6 and 36.2 ng L-1), propranolol (28.5, 63.9 and 78.4 ng L-1), ibuprofen (53.9 and 10.9 ng L-1), diclofenac (13.4, 42.7 and 22.0 ng L-1). This work contributes to the elaboration of an important scenario of water quality of surface water source of the city São Carlos, which can support public policies for the preservation of the quality of the environment and human health through the development of public policies that inhibit economically predatory initiatives that are harmful to the environment. |
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Schio, Natalí da SilvaFadini, Pedro Sérgiohttp://lattes.cnpq.br/3255060531838427Tanaka, Marcel Okamotohttp://lattes.cnpq.br/2768658925977757http://lattes.cnpq.br/99160030024381662022-02-11T14:22:05Z2022-02-11T14:22:05Z2021-11-24SCHIO, Natalí da Silva. Determinação de pesticidas organoclorados e fármacos em matrizes ambientais utilizando QuEChERS, extração líquido-líquido (LLE) e extração em fase sólida (SPE). 2021. Dissertação (Mestrado em Química) – Universidade Federal de São Carlos, São Carlos, 2021. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15588.https://repositorio.ufscar.br/handle/ufscar/15588The presence of xenobiotic organic contaminants in water bodies, where arrive from releases of treated or untreated effluent, has raised concerns about impacts related to the richness and biodiversity of aquatic life and human health. Considering the possibility of the increasing presence, persistence, and pseudo-persistence of pesticide and drugs in the environment and possible deleterious effect resulting from it, the objective of this work was to develop and to validate a multi-residue method using QuEChERS and Liquid-Liquid Extraction (LLE), for determination of organochlorine compounds (Aldrin, heptachlor, heptachlor epoxide, endosulfan (α and β), endosulfan sulfate, 4,4'-DEE, dieldrim, endrin, 4,4'-DDD, 4,4'-DDT, endrin aldehyde, Methoxychlor and hexachlorocyclohexane (α-BHC, β-BHC, γ-BHC e δ-BHC)) in soil, sediment, and freshwater, with gas chromatography-tandem electron capture detector (GC/ECD) and Solid Phase Extraction (SPE) for drugs quantification (Carbamazepine, Atenolol, Propranolol, CBZ-DiOH, Caffeine, Naproxen, Ibuprofen, 2-Hydroxycarbamazepine, Estrone, 17-β-estradiol, 17-α-ethinylestradiol, Paracetamol, 2-Hydroxy-ibuprofen and Diclofenac) in freshwater using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), in the collected sample in the regions of Hydrographic Sub-Basin of Ribeirão do Feijão and Hydrographic Sub-Basin of Rio Quilombo, in São Carlos, SP. The proposed method for organochlorine compounds determination was valid for all matrices. For solid samples, the analyte recoveries (%Rec) were between 50% and 117%, with a coefficient of variation (%CV) below 19 and linear correlation coefficient (R2) greater than 0.98, for all analytes. The value of matrix effect (ME) was between -8.73% for α-BHC and 585.35% for endrin. The limit of detection (LOD) was 0.759 µg Kg-1 for 4,4’-DDD and 2.144 µg Kg-1 for endosulfan sulfate, and the limit of quantification (LOQ) was between 2.528 µg Kg-1 and 7.147 µg Kg-1 , for the same analytes. The %Rec was between 40% and 144% for the freshwater sample, with %CV below 24 for 16 analytes analyzed. All R2 was greater than 0.99. The LOD ranged from 1.641 ng L-1 for α-BHC to 4.433 ng L-1 for endosulfan sulfate, while the LOQ was 5.473 ng L-1 and 14.779 ng L-1 for the same analytes. The ME was -13.73% for α-BHC and 393.43% for endrin. Regarding the determination of drugs in freshwater, the %Rec ranges from 93% to 120%, with %CV below ten and R2 greater than 0.98 for all analytes. The values of LOD ranged from 2.885 ng L-1 for ibuprofen to 5.293 ng L-1 for 17-β-estradiol, while the values of LOQ ranged from 9.618 ng L-1 to 17.642 ng L-1, for the same analytes. Regarding collected samples, the analysis performed to the determination of organochlorine compounds showed results below LOD. This was observed for the three matrices in all collect performed. In the analysis for drugs determination, the presence of ten analytes was observed. The caffeine was in all analyzed samples, with concentrations 105.2, 54.9, 52.3, and 184.4 ng L-1. The other analytes determined were atenolol (52.8, 28.3 and 17.2 ng L-1), carbamazepine (22.8, 17.6 and 36.2 ng L-1), propranolol (28.5, 63.9 and 78.4 ng L-1), ibuprofen (53.9 and 10.9 ng L-1), diclofenac (13.4, 42.7 and 22.0 ng L-1). This work contributes to the elaboration of an important scenario of water quality of surface water source of the city São Carlos, which can support public policies for the preservation of the quality of the environment and human health through the development of public policies that inhibit economically predatory initiatives that are harmful to the environment.A presença de contaminantes orgânicos xenobióticos em corpos hídricos, onde chegam a partir do lançamento de efluentes tratados ou não, tem gerado preocupações quanto a impactos relacionados à riqueza e biodiversidade da vida aquática e à saúde humana. Considerando a possibilidade da presença crescente, persistência e pseudo-persistência de pesticidas e fármacos no ambiente, e possíveis efeitos deletérios decorrentes, este trabalho teve como objetivo desenvolver e validar um método multirresíduo usando QuEChERS e Extração Líquido-Líquido (LLE), para determinação dos compostos organoclorados Aldrin, heptacloro, heptacloro epóxido, endosulfan (α e β),endossulfan sulfato , 4,4’-DEE, dieldrim, endrin, 4,4’- DDD, 4,4’-DDT, endrin aldeído, metoxicloro e hexaclorociclohexano (α-BHC, β-BHC, γ-BHC e δ-BHC) em solo, sedimento e água superficial, utilizando cromatografia gasosa acoplada ao detector de captura de elétrons (GC/ECD) e Extração em Fase Sólida (SPE) para a quantificação de fármacos (Carbamazepina, Atenolol, Propranolol, CBZ-DiOH, Cafeína, Naproxeno, Ibuprofeno, 2-Hidroxicarbamazepina, Estrona, 17-β-estradiol, 17-α-etinilestradiol, Paracetamol, 2-Hidroxi-ibuprofeno e Diclofenaco) em águas superficiais utilizando cromatografia líquida de alta eficiência (UPLC-MS/MS), em amostras coletadas nas regiões das Sub-Bacias Hidrográficas do Ribeirão do Feijão e do Rio Quilombo, no município de São Carlos, SP. Os métodos propostos para a determinação de organoclorados se mostraram válidos para todas as matrizes. Para as amostras sólidas, as porcentagens de recuperação (%Rec) dos analitos variaram entre 50% e 117%, com coeficientes de variação (CV) inferiores a 19% e coeficientes de correlação linear (R2) superiores a 0,98, para todos os analitos. Na avaliação de efeito matriz (EM) foram obtidos efeitos entre -8,73% e 585,35% para o α-BHC e para o endrin, respectivamente. Os limites de detecção (LDm) ficaram entre 0,759 µg Kg-1, para o 4,4’-DDD, e 2,144 µg Kg-1 para o endosulfan sulfato, enquanto os limites de quantificação (LQm) variaram entre 2,528 µg Kg-1 e 7,147 µg Kg-1 para os mesmos analitos. Para as amostras de água, as %Rec variaram de 40% até 144%, com CV inferiores a 24% para 16 dos analitos estudados. Todos os R2 obtidos foram superiores a 0,99. O LDm variou de 1,641 ng L-1 até 4,433 ng L-1, enquanto o LQm ficou entre 5,473 ng L-1 e 14,779 ng L-1 para o α-BHC e endosulfan sulfato, respectivamente. O efeito matriz (EM) foi de -13,73% para o α-BHC até 393,43% para o endrin. Com relação à determinação de fármacos em água, as %Rec ficaram entre 93% e 120%, com CV inferiores a 10% e R2 superiores a 0,98 para todos os analitos estudados. Sobre os valores dos LDm e LQm, o primeiro variou de 2,885 ng L-1 para o ibuprofeno até 5,293 ng L-1 para 17-β-estradiol, enquanto o segundo variou entre 9,618 ng L-1 e 17,642 ng L-1, para os mesmos analitos. Em relação as amostras coletadas, as análises feitas para a determinação dos organoclorados apresentaram resultados abaixo do limite de detecção. Este comportamento foi observado para todas as 3 matrizes, em todas as coletas realizadas. Nas análises para a determinação dos fármacos, foram observadas a presença de 10 analitos. A cafeína foi encontrada em todas as amostras, com concentrações de 105,2, 54,9, 52,3 e 184,4 ng L-1 . Os demais analitos determinados foram: atenolol (52,8, 28,3 e 17,2 ng L-1), carbamazepina (22,8, 17,6 e 36,2 ng L-1), propranolol (28,5, 63,9 e 78,4 ng L-1), ibuprofeno (53,9 e 10,9 ng L-1) e diclofenaco (13,4, 42,7 e 22,0 ng L-1). Este trabalho está permitindo a elaboração de um importante cenário da qualidade das águas dos mananciais superficiais da cidade de São Carlos, buscando a identificação de valores de referência das primeiras décadas do século XXI, que possam ser utilizados em estudos e balizamentos de políticas públicas voltados à preservação ambiental da área e especialmente dos recursos hídricos.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)CAPES: Código de Financiamento 001porUniversidade Federal de São CarlosCâmpus São CarlosPrograma de Pós-Graduação em Química - PPGQUFSCarAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessOrganocloradosFármacosQuEChERSLLESPEOrganochlorinesDrugsCIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA ANALITICA::ANALISE DE TRACOS E QUIMICA AMBIENTALDeterminação de pesticidas organoclorados e fármacos em matrizes ambientais utilizando QuEChERS, extração líquido-líquido (LLE) e extração em fase sólida (SPE)Determination of organochlorine pesticides and drugs in environmental matrices using QuEChERS, liquid-liquid extraction (LLE) and solid phase extraction (SPE)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisreponame:Repositório Institucional da UFSCARinstname:Universidade Federal de São Carlos (UFSCAR)instacron:UFSCARORIGINALDissertação_Natalí Schio_final.pdfDissertação_Natalí Schio_final.pdfDissertaçãoapplication/pdf2262655https://repositorio.ufscar.br/bitstream/ufscar/15588/3/Disserta%c3%a7%c3%a3o_Natal%c3%ad%20Schio_final.pdf786870340b3971fd166295d7eb2daf5dMD53Carta-comprovante_homologacao.pdfCarta-comprovante_homologacao.pdfCarta comprovanteapplication/pdf172782https://repositorio.ufscar.br/bitstream/ufscar/15588/4/Carta-comprovante_homologacao.pdf021db3735eda323e428a452942cc5bc9MD54CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.ufscar.br/bitstream/ufscar/15588/5/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD55TEXTDissertação_Natalí Schio_final.pdf.txtDissertação_Natalí Schio_final.pdf.txtExtracted texttext/plain161846https://repositorio.ufscar.br/bitstream/ufscar/15588/6/Disserta%c3%a7%c3%a3o_Natal%c3%ad%20Schio_final.pdf.txt0ca245abd4ced6ad882b170675fef25dMD56Carta-comprovante_homologacao.pdf.txtCarta-comprovante_homologacao.pdf.txtExtracted texttext/plain1947https://repositorio.ufscar.br/bitstream/ufscar/15588/8/Carta-comprovante_homologacao.pdf.txt143f82ce07b788dc12158efee6b12b79MD58THUMBNAILDissertação_Natalí Schio_final.pdf.jpgDissertação_Natalí Schio_final.pdf.jpgIM Thumbnailimage/jpeg10536https://repositorio.ufscar.br/bitstream/ufscar/15588/7/Disserta%c3%a7%c3%a3o_Natal%c3%ad%20Schio_final.pdf.jpgebfbdd3661e70ebe92b4fbbb3f255e4fMD57Carta-comprovante_homologacao.pdf.jpgCarta-comprovante_homologacao.pdf.jpgIM Thumbnailimage/jpeg12913https://repositorio.ufscar.br/bitstream/ufscar/15588/9/Carta-comprovante_homologacao.pdf.jpg816940059149c45af55f3a9d6b036173MD59ufscar/155882022-02-12 03:38:10.765oai:repositorio.ufscar.br:ufscar/15588Repositório InstitucionalPUBhttps://repositorio.ufscar.br/oai/requestopendoar:43222022-02-12T03:38:10Repositório Institucional da UFSCAR - Universidade Federal de São Carlos (UFSCAR)false |
dc.title.por.fl_str_mv |
Determinação de pesticidas organoclorados e fármacos em matrizes ambientais utilizando QuEChERS, extração líquido-líquido (LLE) e extração em fase sólida (SPE) |
dc.title.alternative.eng.fl_str_mv |
Determination of organochlorine pesticides and drugs in environmental matrices using QuEChERS, liquid-liquid extraction (LLE) and solid phase extraction (SPE) |
title |
Determinação de pesticidas organoclorados e fármacos em matrizes ambientais utilizando QuEChERS, extração líquido-líquido (LLE) e extração em fase sólida (SPE) |
spellingShingle |
Determinação de pesticidas organoclorados e fármacos em matrizes ambientais utilizando QuEChERS, extração líquido-líquido (LLE) e extração em fase sólida (SPE) Schio, Natalí da Silva Organoclorados Fármacos QuEChERS LLE SPE Organochlorines Drugs CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA ANALITICA::ANALISE DE TRACOS E QUIMICA AMBIENTAL |
title_short |
Determinação de pesticidas organoclorados e fármacos em matrizes ambientais utilizando QuEChERS, extração líquido-líquido (LLE) e extração em fase sólida (SPE) |
title_full |
Determinação de pesticidas organoclorados e fármacos em matrizes ambientais utilizando QuEChERS, extração líquido-líquido (LLE) e extração em fase sólida (SPE) |
title_fullStr |
Determinação de pesticidas organoclorados e fármacos em matrizes ambientais utilizando QuEChERS, extração líquido-líquido (LLE) e extração em fase sólida (SPE) |
title_full_unstemmed |
Determinação de pesticidas organoclorados e fármacos em matrizes ambientais utilizando QuEChERS, extração líquido-líquido (LLE) e extração em fase sólida (SPE) |
title_sort |
Determinação de pesticidas organoclorados e fármacos em matrizes ambientais utilizando QuEChERS, extração líquido-líquido (LLE) e extração em fase sólida (SPE) |
author |
Schio, Natalí da Silva |
author_facet |
Schio, Natalí da Silva |
author_role |
author |
dc.contributor.authorlattes.por.fl_str_mv |
http://lattes.cnpq.br/9916003002438166 |
dc.contributor.author.fl_str_mv |
Schio, Natalí da Silva |
dc.contributor.advisor1.fl_str_mv |
Fadini, Pedro Sérgio |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3255060531838427 |
dc.contributor.advisor-co1.fl_str_mv |
Tanaka, Marcel Okamoto |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/2768658925977757 |
contributor_str_mv |
Fadini, Pedro Sérgio Tanaka, Marcel Okamoto |
dc.subject.por.fl_str_mv |
Organoclorados Fármacos QuEChERS LLE SPE |
topic |
Organoclorados Fármacos QuEChERS LLE SPE Organochlorines Drugs CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA ANALITICA::ANALISE DE TRACOS E QUIMICA AMBIENTAL |
dc.subject.eng.fl_str_mv |
Organochlorines Drugs |
dc.subject.cnpq.fl_str_mv |
CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA ANALITICA::ANALISE DE TRACOS E QUIMICA AMBIENTAL |
description |
The presence of xenobiotic organic contaminants in water bodies, where arrive from releases of treated or untreated effluent, has raised concerns about impacts related to the richness and biodiversity of aquatic life and human health. Considering the possibility of the increasing presence, persistence, and pseudo-persistence of pesticide and drugs in the environment and possible deleterious effect resulting from it, the objective of this work was to develop and to validate a multi-residue method using QuEChERS and Liquid-Liquid Extraction (LLE), for determination of organochlorine compounds (Aldrin, heptachlor, heptachlor epoxide, endosulfan (α and β), endosulfan sulfate, 4,4'-DEE, dieldrim, endrin, 4,4'-DDD, 4,4'-DDT, endrin aldehyde, Methoxychlor and hexachlorocyclohexane (α-BHC, β-BHC, γ-BHC e δ-BHC)) in soil, sediment, and freshwater, with gas chromatography-tandem electron capture detector (GC/ECD) and Solid Phase Extraction (SPE) for drugs quantification (Carbamazepine, Atenolol, Propranolol, CBZ-DiOH, Caffeine, Naproxen, Ibuprofen, 2-Hydroxycarbamazepine, Estrone, 17-β-estradiol, 17-α-ethinylestradiol, Paracetamol, 2-Hydroxy-ibuprofen and Diclofenac) in freshwater using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), in the collected sample in the regions of Hydrographic Sub-Basin of Ribeirão do Feijão and Hydrographic Sub-Basin of Rio Quilombo, in São Carlos, SP. The proposed method for organochlorine compounds determination was valid for all matrices. For solid samples, the analyte recoveries (%Rec) were between 50% and 117%, with a coefficient of variation (%CV) below 19 and linear correlation coefficient (R2) greater than 0.98, for all analytes. The value of matrix effect (ME) was between -8.73% for α-BHC and 585.35% for endrin. The limit of detection (LOD) was 0.759 µg Kg-1 for 4,4’-DDD and 2.144 µg Kg-1 for endosulfan sulfate, and the limit of quantification (LOQ) was between 2.528 µg Kg-1 and 7.147 µg Kg-1 , for the same analytes. The %Rec was between 40% and 144% for the freshwater sample, with %CV below 24 for 16 analytes analyzed. All R2 was greater than 0.99. The LOD ranged from 1.641 ng L-1 for α-BHC to 4.433 ng L-1 for endosulfan sulfate, while the LOQ was 5.473 ng L-1 and 14.779 ng L-1 for the same analytes. The ME was -13.73% for α-BHC and 393.43% for endrin. Regarding the determination of drugs in freshwater, the %Rec ranges from 93% to 120%, with %CV below ten and R2 greater than 0.98 for all analytes. The values of LOD ranged from 2.885 ng L-1 for ibuprofen to 5.293 ng L-1 for 17-β-estradiol, while the values of LOQ ranged from 9.618 ng L-1 to 17.642 ng L-1, for the same analytes. Regarding collected samples, the analysis performed to the determination of organochlorine compounds showed results below LOD. This was observed for the three matrices in all collect performed. In the analysis for drugs determination, the presence of ten analytes was observed. The caffeine was in all analyzed samples, with concentrations 105.2, 54.9, 52.3, and 184.4 ng L-1. The other analytes determined were atenolol (52.8, 28.3 and 17.2 ng L-1), carbamazepine (22.8, 17.6 and 36.2 ng L-1), propranolol (28.5, 63.9 and 78.4 ng L-1), ibuprofen (53.9 and 10.9 ng L-1), diclofenac (13.4, 42.7 and 22.0 ng L-1). This work contributes to the elaboration of an important scenario of water quality of surface water source of the city São Carlos, which can support public policies for the preservation of the quality of the environment and human health through the development of public policies that inhibit economically predatory initiatives that are harmful to the environment. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-11-24 |
dc.date.accessioned.fl_str_mv |
2022-02-11T14:22:05Z |
dc.date.available.fl_str_mv |
2022-02-11T14:22:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SCHIO, Natalí da Silva. Determinação de pesticidas organoclorados e fármacos em matrizes ambientais utilizando QuEChERS, extração líquido-líquido (LLE) e extração em fase sólida (SPE). 2021. Dissertação (Mestrado em Química) – Universidade Federal de São Carlos, São Carlos, 2021. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15588. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufscar.br/handle/ufscar/15588 |
identifier_str_mv |
SCHIO, Natalí da Silva. Determinação de pesticidas organoclorados e fármacos em matrizes ambientais utilizando QuEChERS, extração líquido-líquido (LLE) e extração em fase sólida (SPE). 2021. Dissertação (Mestrado em Química) – Universidade Federal de São Carlos, São Carlos, 2021. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15588. |
url |
https://repositorio.ufscar.br/handle/ufscar/15588 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de São Carlos Câmpus São Carlos |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Química - PPGQ |
dc.publisher.initials.fl_str_mv |
UFSCar |
publisher.none.fl_str_mv |
Universidade Federal de São Carlos Câmpus São Carlos |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFSCAR instname:Universidade Federal de São Carlos (UFSCAR) instacron:UFSCAR |
instname_str |
Universidade Federal de São Carlos (UFSCAR) |
instacron_str |
UFSCAR |
institution |
UFSCAR |
reponame_str |
Repositório Institucional da UFSCAR |
collection |
Repositório Institucional da UFSCAR |
bitstream.url.fl_str_mv |
https://repositorio.ufscar.br/bitstream/ufscar/15588/3/Disserta%c3%a7%c3%a3o_Natal%c3%ad%20Schio_final.pdf https://repositorio.ufscar.br/bitstream/ufscar/15588/4/Carta-comprovante_homologacao.pdf https://repositorio.ufscar.br/bitstream/ufscar/15588/5/license_rdf https://repositorio.ufscar.br/bitstream/ufscar/15588/6/Disserta%c3%a7%c3%a3o_Natal%c3%ad%20Schio_final.pdf.txt https://repositorio.ufscar.br/bitstream/ufscar/15588/8/Carta-comprovante_homologacao.pdf.txt https://repositorio.ufscar.br/bitstream/ufscar/15588/7/Disserta%c3%a7%c3%a3o_Natal%c3%ad%20Schio_final.pdf.jpg https://repositorio.ufscar.br/bitstream/ufscar/15588/9/Carta-comprovante_homologacao.pdf.jpg |
bitstream.checksum.fl_str_mv |
786870340b3971fd166295d7eb2daf5d 021db3735eda323e428a452942cc5bc9 e39d27027a6cc9cb039ad269a5db8e34 0ca245abd4ced6ad882b170675fef25d 143f82ce07b788dc12158efee6b12b79 ebfbdd3661e70ebe92b4fbbb3f255e4f 816940059149c45af55f3a9d6b036173 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFSCAR - Universidade Federal de São Carlos (UFSCAR) |
repository.mail.fl_str_mv |
|
_version_ |
1777472147256508416 |