Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFSCAR |
Texto Completo: | https://doi.org/10.1016/j.rmed.2021.106389 https://repositorio.ufscar.br/handle/ufscar/15555 |
Resumo: | Purpose: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with an elevated risk of cardiovascular events, which can be linked to endothelial dysfunction. In this study, we aimed to investigate whether noninvasive ventilation (NIV) acutely changes endothelial function in hospitalized AECOPD patients. Methods: Twenty-one AECOPD patients were assessed in a hospital ward setting from 24 to 48 h after admission. NIV was applied using a ventilator with bilevel pressure support. Before and after NIV protocol, patients were evaluated regarding (1) endothelium-dependent function, assessed non-invasively using the flow-mediated dilation (FMD) method; (2) arterial blood gas analysis. Other baseline evaluations included clinical and anthropometric data, and laboratory tests. Results: The total group showed a significant improvement in FMD as a result of NIV effect (P = 0.010). While arterial carbon dioxide and oxygen were not altered, oxygen saturation increased after NIV (P = 0.045). The subgroup comparison of responders (FMD ≥ 1%) and non-responders (FMD < 1%) showed significant baseline differences in body mass index (BMI) (P = 0.019) and predicted forced expiratory volume in one second (FEV1) (P = 0.007). In univariate and multivariate analyses, both BMI and FEV1 were determinant for endothelial response to NIV. Conclusion: NIV acutely improves endothelial function in hospitalized AECOPD patients. Overweight and COPD severity may represent important characteristics for the magnitude of peripheral vascular response. |
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Heubel, Alessandro DominguesKabbach, Erika ZavagliaSchafauser, Nathany SouzaDi Lorenzo, Valéria Amorim PiresSilva, Audrey BorghiMendes, Renata Gonçalveshttp://lattes.cnpq.br/0268406461810882http://lattes.cnpq.br/4456979306195044http://lattes.cnpq.br/5075933151971198http://lattes.cnpq.br/9071791546812165http://lattes.cnpq.br/4855616925791895http://lattes.cnpq.br/96345909222420522022-02-08T10:41:04Z2022-02-08T10:41:04Z2021-05-01https://doi.org/10.1016/j.rmed.2021.106389HEUBEL, Alessandro Domingues; KABBACH, Erika Zavaglia; SCHAFAUSER, Nathany Souza; DI LORENZO, Valéria Amorim Pires; BORGHI-SILVA, Audrey; MENDES, Renata Gonçalves. Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients. Repositório de Dados da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15555.https://repositorio.ufscar.br/handle/ufscar/15555Purpose: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with an elevated risk of cardiovascular events, which can be linked to endothelial dysfunction. In this study, we aimed to investigate whether noninvasive ventilation (NIV) acutely changes endothelial function in hospitalized AECOPD patients. Methods: Twenty-one AECOPD patients were assessed in a hospital ward setting from 24 to 48 h after admission. NIV was applied using a ventilator with bilevel pressure support. Before and after NIV protocol, patients were evaluated regarding (1) endothelium-dependent function, assessed non-invasively using the flow-mediated dilation (FMD) method; (2) arterial blood gas analysis. Other baseline evaluations included clinical and anthropometric data, and laboratory tests. Results: The total group showed a significant improvement in FMD as a result of NIV effect (P = 0.010). While arterial carbon dioxide and oxygen were not altered, oxygen saturation increased after NIV (P = 0.045). The subgroup comparison of responders (FMD ≥ 1%) and non-responders (FMD < 1%) showed significant baseline differences in body mass index (BMI) (P = 0.019) and predicted forced expiratory volume in one second (FEV1) (P = 0.007). In univariate and multivariate analyses, both BMI and FEV1 were determinant for endothelial response to NIV. Conclusion: NIV acutely improves endothelial function in hospitalized AECOPD patients. Overweight and COPD severity may represent important characteristics for the magnitude of peripheral vascular response.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Código de Financiamento 001 - CAPESProcesso nº 2015/12763-4, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Processo nº 2015/26501–1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)engUniversidade Federal de São CarlosCâmpus São CarlosPrograma de Pós-Graduação em Fisioterapia - PPGFtUFSCarDepartamento de Fisioterapia - DFisiohttps://www.resmedjournal.com/article/S0954-6111(21)00095-0/fulltext#relatedArticlesAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessChronic obstructive pulmonary diseaseNoninvasive ventilationPeripheral vascular functionCIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONALNoninvasive ventilation acutely improves endothelial function in exacerbated COPD patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/datasetreponame:Repositório Institucional da UFSCARinstname:Universidade Federal de São Carlos (UFSCAR)instacron:UFSCARORIGINALNIV acutely improves endothelial function in exacerbated COPD.xlsxNIV acutely improves endothelial function in exacerbated COPD.xlsxDados de pesquisaapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheet20911https://repositorio.ufscar.br/bitstream/ufscar/15555/1/NIV%20acutely%20improves%20endothelial%20function%20in%20exacerbated%20COPD.xlsxe87da2a7f7fabeea3a8e65788e9c35b6MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.ufscar.br/bitstream/ufscar/15555/2/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD52ufscar/155552022-02-16 18:09:44.257oai:repositorio.ufscar.br:ufscar/15555Repositório InstitucionalPUBhttps://repositorio.ufscar.br/oai/requestopendoar:43222022-02-16T18:09:44Repositório Institucional da UFSCAR - Universidade Federal de São Carlos (UFSCAR)false |
dc.title.eng.fl_str_mv |
Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients |
title |
Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients |
spellingShingle |
Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients Heubel, Alessandro Domingues Chronic obstructive pulmonary disease Noninvasive ventilation Peripheral vascular function CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL |
title_short |
Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients |
title_full |
Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients |
title_fullStr |
Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients |
title_full_unstemmed |
Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients |
title_sort |
Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients |
author |
Heubel, Alessandro Domingues |
author_facet |
Heubel, Alessandro Domingues Kabbach, Erika Zavaglia Schafauser, Nathany Souza Di Lorenzo, Valéria Amorim Pires Silva, Audrey Borghi Mendes, Renata Gonçalves |
author_role |
author |
author2 |
Kabbach, Erika Zavaglia Schafauser, Nathany Souza Di Lorenzo, Valéria Amorim Pires Silva, Audrey Borghi Mendes, Renata Gonçalves |
author2_role |
author author author author author |
dc.contributor.authorlattes.por.fl_str_mv |
http://lattes.cnpq.br/0268406461810882 http://lattes.cnpq.br/4456979306195044 http://lattes.cnpq.br/5075933151971198 http://lattes.cnpq.br/9071791546812165 http://lattes.cnpq.br/4855616925791895 http://lattes.cnpq.br/9634590922242052 |
dc.contributor.author.fl_str_mv |
Heubel, Alessandro Domingues Kabbach, Erika Zavaglia Schafauser, Nathany Souza Di Lorenzo, Valéria Amorim Pires Silva, Audrey Borghi Mendes, Renata Gonçalves |
dc.subject.eng.fl_str_mv |
Chronic obstructive pulmonary disease Noninvasive ventilation Peripheral vascular function |
topic |
Chronic obstructive pulmonary disease Noninvasive ventilation Peripheral vascular function CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL |
description |
Purpose: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with an elevated risk of cardiovascular events, which can be linked to endothelial dysfunction. In this study, we aimed to investigate whether noninvasive ventilation (NIV) acutely changes endothelial function in hospitalized AECOPD patients. Methods: Twenty-one AECOPD patients were assessed in a hospital ward setting from 24 to 48 h after admission. NIV was applied using a ventilator with bilevel pressure support. Before and after NIV protocol, patients were evaluated regarding (1) endothelium-dependent function, assessed non-invasively using the flow-mediated dilation (FMD) method; (2) arterial blood gas analysis. Other baseline evaluations included clinical and anthropometric data, and laboratory tests. Results: The total group showed a significant improvement in FMD as a result of NIV effect (P = 0.010). While arterial carbon dioxide and oxygen were not altered, oxygen saturation increased after NIV (P = 0.045). The subgroup comparison of responders (FMD ≥ 1%) and non-responders (FMD < 1%) showed significant baseline differences in body mass index (BMI) (P = 0.019) and predicted forced expiratory volume in one second (FEV1) (P = 0.007). In univariate and multivariate analyses, both BMI and FEV1 were determinant for endothelial response to NIV. Conclusion: NIV acutely improves endothelial function in hospitalized AECOPD patients. Overweight and COPD severity may represent important characteristics for the magnitude of peripheral vascular response. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-05-01 |
dc.date.accessioned.fl_str_mv |
2022-02-08T10:41:04Z |
dc.date.available.fl_str_mv |
2022-02-08T10:41:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/dataset |
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publishedVersion |
dc.identifier.por.fl_str_mv |
https://doi.org/10.1016/j.rmed.2021.106389 |
dc.identifier.citation.fl_str_mv |
HEUBEL, Alessandro Domingues; KABBACH, Erika Zavaglia; SCHAFAUSER, Nathany Souza; DI LORENZO, Valéria Amorim Pires; BORGHI-SILVA, Audrey; MENDES, Renata Gonçalves. Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients. Repositório de Dados da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15555. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufscar.br/handle/ufscar/15555 |
url |
https://doi.org/10.1016/j.rmed.2021.106389 https://repositorio.ufscar.br/handle/ufscar/15555 |
identifier_str_mv |
HEUBEL, Alessandro Domingues; KABBACH, Erika Zavaglia; SCHAFAUSER, Nathany Souza; DI LORENZO, Valéria Amorim Pires; BORGHI-SILVA, Audrey; MENDES, Renata Gonçalves. Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients. Repositório de Dados da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15555. |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.uri.por.fl_str_mv |
https://www.resmedjournal.com/article/S0954-6111(21)00095-0/fulltext#relatedArticles |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de São Carlos Câmpus São Carlos |
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Programa de Pós-Graduação em Fisioterapia - PPGFt |
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UFSCar |
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Departamento de Fisioterapia - DFisio |
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Universidade Federal de São Carlos Câmpus São Carlos |
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