Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFSCAR |
Texto Completo: | https://doi.org/10.1016/j.rmed.2021.106511 https://repositorio.ufscar.br/handle/ufscar/15572 |
Resumo: | Purpose: Impairment of cardiac autonomic integrity is common in chronic obstructive pulmonary disease (COPD) patients. The influence of the interaction between clinical and severity status on brain-heart autonomic axis (BHAA) is not well known. We aimed to investigate the BHAA function across different clinical status and severity of COPD. Methods: Cross-sectional study involving 77 COPD patients allocated into four groups according to clinical status [acute exacerbation (GAE) or stable (GST)] and severity [less (-) or more (+)]: 1) GAE-, n = 13; 2) GAE+, n = 20; 3) GST-, n = 23; and 4) GST+, n = 21. Heart rate variability (HRV) at rest and heart rate recovery (HRR) after 6-min walk test were markers of BHAA. Mean R-R, STDRR, RMSSD, RRtri, HF, LF, SD1, SD2, ApEn and SampEn were the HRV indexes and, HRR was obtained as: HR at 1st min of recovery minus peak HR. Results: A main effect of clinical status (p < 0.001) was found to vagal modulation in GAE-vs. GST- (RMSSD: 25.0 ± 14.8 vs. 12.6 ± 5.5 ms; SD1: 18.0 ± 10.6 vs. 8.9 ± 3.9 ms) and to GAE + vs. GST+ (RMSSD: 26.4 ± 15.2 vs. 15.4 ± 6.3 ms; SD1: 18.3 ± 11.2 vs. 10.9 ± 4.5 ms). An effect of clinical status (p = 0.032) and severity (p = 0.030) were found to HF (vagal) in GAE + compared to GAE- and GST+ (264.7 ± 239.0 vs. 134.7 ± 169.7 and 135.8 ± 139.7 ms2). Lower HRR was found in GAE-compared to GST- (8.0 ± 2.4 vs. 19.6 ± 2.4 bpm), p = 0.002. Conclusion: In COPD patients, clinical status (AECOPD or stable) was more dominant than the severity on BHAA function. A more pronounced parasympathetic modulation was found in AECOPD patients with a lower HRR to exercise. |
id |
SCAR_ff9625db850a03d052ed146401071279 |
---|---|
oai_identifier_str |
oai:repositorio.ufscar.br:ufscar/15572 |
network_acronym_str |
SCAR |
network_name_str |
Repositório Institucional da UFSCAR |
repository_id_str |
|
spelling |
Castello-Simões, VivianeKabbach, Erika ZavagliaSchafauser, Nathany SouzaCamargo, Patrícia FariaSimões, Rodrigo PolaquiniHeubel, Alessandro DominguesAlqahtani, Jaber SaudPereira, Mariana Brasil da Cunha MartinoSgarbosa, Nicole MarquesSilva, Audrey BorghiMendes, Renata Gonçalveshttp://lattes.cnpq.br/8573168804662842http://lattes.cnpq.br/4456979306195044http://lattes.cnpq.br/5075933151971198http://lattes.cnpq.br/8975177658472167http://lattes.cnpq.br/2731345085062145http://lattes.cnpq.br/0268406461810882http://lattes.cnpq.br/6818839151532121http://lattes.cnpq.br/8045534712864333http://lattes.cnpq.br/4855616925791895http://lattes.cnpq.br/96345909222420522022-02-09T10:31:18Z2022-02-09T10:31:18Z2021-06-19https://doi.org/10.1016/j.rmed.2021.106511CASTELLO-SIMÕES, Viviane; KABBACK, Erika Zavaglia; SCHAFAUSER, Nathany Souza; CAMARGO, Patricia Faria; SIMÕES, Rodrigo Polaquini; HEUBEL, Alessandro Domingues; ALQAHTANI, Jaber Saud; PEREIRA, Mariana Brasil da Cunha Martino; SGARBOSA, Nicole Marques; BORGHI-SILVA, Audrey; MENDES, Renata Gonçalves. Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease. Repositório de Dados da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15572.https://repositorio.ufscar.br/handle/ufscar/15572Purpose: Impairment of cardiac autonomic integrity is common in chronic obstructive pulmonary disease (COPD) patients. The influence of the interaction between clinical and severity status on brain-heart autonomic axis (BHAA) is not well known. We aimed to investigate the BHAA function across different clinical status and severity of COPD. Methods: Cross-sectional study involving 77 COPD patients allocated into four groups according to clinical status [acute exacerbation (GAE) or stable (GST)] and severity [less (-) or more (+)]: 1) GAE-, n = 13; 2) GAE+, n = 20; 3) GST-, n = 23; and 4) GST+, n = 21. Heart rate variability (HRV) at rest and heart rate recovery (HRR) after 6-min walk test were markers of BHAA. Mean R-R, STDRR, RMSSD, RRtri, HF, LF, SD1, SD2, ApEn and SampEn were the HRV indexes and, HRR was obtained as: HR at 1st min of recovery minus peak HR. Results: A main effect of clinical status (p < 0.001) was found to vagal modulation in GAE-vs. GST- (RMSSD: 25.0 ± 14.8 vs. 12.6 ± 5.5 ms; SD1: 18.0 ± 10.6 vs. 8.9 ± 3.9 ms) and to GAE + vs. GST+ (RMSSD: 26.4 ± 15.2 vs. 15.4 ± 6.3 ms; SD1: 18.3 ± 11.2 vs. 10.9 ± 4.5 ms). An effect of clinical status (p = 0.032) and severity (p = 0.030) were found to HF (vagal) in GAE + compared to GAE- and GST+ (264.7 ± 239.0 vs. 134.7 ± 169.7 and 135.8 ± 139.7 ms2). Lower HRR was found in GAE-compared to GST- (8.0 ± 2.4 vs. 19.6 ± 2.4 bpm), p = 0.002. Conclusion: In COPD patients, clinical status (AECOPD or stable) was more dominant than the severity on BHAA function. A more pronounced parasympathetic modulation was found in AECOPD patients with a lower HRR to exercise.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Processo nº 2015/26501–1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Código de Financiamento 001 - CAPESengUniversidade Federal de São CarlosCâmpus São CarlosPrograma de Pós-Graduação em Fisioterapia - PPGFtUFSCarDepartamento de Fisioterapia - DFisiohttps://www.sciencedirect.com/science/article/pii/S0954611121002171https://repositorio.ufscar.br/handle/ufscar/13767Attribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessAcute exacerbationAutonomic nervous systemExerciseHeart rate variabilityRespiratory diseaseCIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONALBrain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/datasetreponame:Repositório Institucional da UFSCARinstname:Universidade Federal de São Carlos (UFSCAR)instacron:UFSCARORIGINALDados de pesquisa.xlsxDados de pesquisa.xlsxDados do artigo cientifico publicadoapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheet54224https://repositorio.ufscar.br/bitstream/ufscar/15572/3/Dados%20de%20pesquisa.xlsxf30ae21ef799195a8946b2ba09c43d41MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.ufscar.br/bitstream/ufscar/15572/4/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD54ufscar/155722022-12-13 18:35:26.218oai:repositorio.ufscar.br:ufscar/15572Repositório InstitucionalPUBhttps://repositorio.ufscar.br/oai/requestopendoar:43222022-12-13T18:35:26Repositório Institucional da UFSCAR - Universidade Federal de São Carlos (UFSCAR)false |
dc.title.eng.fl_str_mv |
Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease |
title |
Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease |
spellingShingle |
Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease Castello-Simões, Viviane Acute exacerbation Autonomic nervous system Exercise Heart rate variability Respiratory disease CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL |
title_short |
Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease |
title_full |
Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease |
title_fullStr |
Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease |
title_full_unstemmed |
Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease |
title_sort |
Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease |
author |
Castello-Simões, Viviane |
author_facet |
Castello-Simões, Viviane Kabbach, Erika Zavaglia Schafauser, Nathany Souza Camargo, Patrícia Faria Simões, Rodrigo Polaquini Heubel, Alessandro Domingues Alqahtani, Jaber Saud Pereira, Mariana Brasil da Cunha Martino Sgarbosa, Nicole Marques Silva, Audrey Borghi Mendes, Renata Gonçalves |
author_role |
author |
author2 |
Kabbach, Erika Zavaglia Schafauser, Nathany Souza Camargo, Patrícia Faria Simões, Rodrigo Polaquini Heubel, Alessandro Domingues Alqahtani, Jaber Saud Pereira, Mariana Brasil da Cunha Martino Sgarbosa, Nicole Marques Silva, Audrey Borghi Mendes, Renata Gonçalves |
author2_role |
author author author author author author author author author author |
dc.contributor.authorlattes.por.fl_str_mv |
http://lattes.cnpq.br/8573168804662842 http://lattes.cnpq.br/4456979306195044 http://lattes.cnpq.br/5075933151971198 http://lattes.cnpq.br/8975177658472167 http://lattes.cnpq.br/2731345085062145 http://lattes.cnpq.br/0268406461810882 http://lattes.cnpq.br/6818839151532121 http://lattes.cnpq.br/8045534712864333 http://lattes.cnpq.br/4855616925791895 http://lattes.cnpq.br/9634590922242052 |
dc.contributor.author.fl_str_mv |
Castello-Simões, Viviane Kabbach, Erika Zavaglia Schafauser, Nathany Souza Camargo, Patrícia Faria Simões, Rodrigo Polaquini Heubel, Alessandro Domingues Alqahtani, Jaber Saud Pereira, Mariana Brasil da Cunha Martino Sgarbosa, Nicole Marques Silva, Audrey Borghi Mendes, Renata Gonçalves |
dc.subject.eng.fl_str_mv |
Acute exacerbation Autonomic nervous system Exercise Heart rate variability Respiratory disease |
topic |
Acute exacerbation Autonomic nervous system Exercise Heart rate variability Respiratory disease CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL |
description |
Purpose: Impairment of cardiac autonomic integrity is common in chronic obstructive pulmonary disease (COPD) patients. The influence of the interaction between clinical and severity status on brain-heart autonomic axis (BHAA) is not well known. We aimed to investigate the BHAA function across different clinical status and severity of COPD. Methods: Cross-sectional study involving 77 COPD patients allocated into four groups according to clinical status [acute exacerbation (GAE) or stable (GST)] and severity [less (-) or more (+)]: 1) GAE-, n = 13; 2) GAE+, n = 20; 3) GST-, n = 23; and 4) GST+, n = 21. Heart rate variability (HRV) at rest and heart rate recovery (HRR) after 6-min walk test were markers of BHAA. Mean R-R, STDRR, RMSSD, RRtri, HF, LF, SD1, SD2, ApEn and SampEn were the HRV indexes and, HRR was obtained as: HR at 1st min of recovery minus peak HR. Results: A main effect of clinical status (p < 0.001) was found to vagal modulation in GAE-vs. GST- (RMSSD: 25.0 ± 14.8 vs. 12.6 ± 5.5 ms; SD1: 18.0 ± 10.6 vs. 8.9 ± 3.9 ms) and to GAE + vs. GST+ (RMSSD: 26.4 ± 15.2 vs. 15.4 ± 6.3 ms; SD1: 18.3 ± 11.2 vs. 10.9 ± 4.5 ms). An effect of clinical status (p = 0.032) and severity (p = 0.030) were found to HF (vagal) in GAE + compared to GAE- and GST+ (264.7 ± 239.0 vs. 134.7 ± 169.7 and 135.8 ± 139.7 ms2). Lower HRR was found in GAE-compared to GST- (8.0 ± 2.4 vs. 19.6 ± 2.4 bpm), p = 0.002. Conclusion: In COPD patients, clinical status (AECOPD or stable) was more dominant than the severity on BHAA function. A more pronounced parasympathetic modulation was found in AECOPD patients with a lower HRR to exercise. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-06-19 |
dc.date.accessioned.fl_str_mv |
2022-02-09T10:31:18Z |
dc.date.available.fl_str_mv |
2022-02-09T10:31:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/dataset |
status_str |
publishedVersion |
dc.identifier.por.fl_str_mv |
https://doi.org/10.1016/j.rmed.2021.106511 |
dc.identifier.citation.fl_str_mv |
CASTELLO-SIMÕES, Viviane; KABBACK, Erika Zavaglia; SCHAFAUSER, Nathany Souza; CAMARGO, Patricia Faria; SIMÕES, Rodrigo Polaquini; HEUBEL, Alessandro Domingues; ALQAHTANI, Jaber Saud; PEREIRA, Mariana Brasil da Cunha Martino; SGARBOSA, Nicole Marques; BORGHI-SILVA, Audrey; MENDES, Renata Gonçalves. Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease. Repositório de Dados da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15572. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufscar.br/handle/ufscar/15572 |
url |
https://doi.org/10.1016/j.rmed.2021.106511 https://repositorio.ufscar.br/handle/ufscar/15572 |
identifier_str_mv |
CASTELLO-SIMÕES, Viviane; KABBACK, Erika Zavaglia; SCHAFAUSER, Nathany Souza; CAMARGO, Patricia Faria; SIMÕES, Rodrigo Polaquini; HEUBEL, Alessandro Domingues; ALQAHTANI, Jaber Saud; PEREIRA, Mariana Brasil da Cunha Martino; SGARBOSA, Nicole Marques; BORGHI-SILVA, Audrey; MENDES, Renata Gonçalves. Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease. Repositório de Dados da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15572. |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.uri.por.fl_str_mv |
https://www.sciencedirect.com/science/article/pii/S0954611121002171 https://repositorio.ufscar.br/handle/ufscar/13767 |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de São Carlos Câmpus São Carlos |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Fisioterapia - PPGFt |
dc.publisher.initials.fl_str_mv |
UFSCar |
dc.publisher.department.fl_str_mv |
Departamento de Fisioterapia - DFisio |
publisher.none.fl_str_mv |
Universidade Federal de São Carlos Câmpus São Carlos |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFSCAR instname:Universidade Federal de São Carlos (UFSCAR) instacron:UFSCAR |
instname_str |
Universidade Federal de São Carlos (UFSCAR) |
instacron_str |
UFSCAR |
institution |
UFSCAR |
reponame_str |
Repositório Institucional da UFSCAR |
collection |
Repositório Institucional da UFSCAR |
bitstream.url.fl_str_mv |
https://repositorio.ufscar.br/bitstream/ufscar/15572/3/Dados%20de%20pesquisa.xlsx https://repositorio.ufscar.br/bitstream/ufscar/15572/4/license_rdf |
bitstream.checksum.fl_str_mv |
f30ae21ef799195a8946b2ba09c43d41 e39d27027a6cc9cb039ad269a5db8e34 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFSCAR - Universidade Federal de São Carlos (UFSCAR) |
repository.mail.fl_str_mv |
|
_version_ |
1777472146996461568 |