Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds

Detalhes bibliográficos
Autor(a) principal: Valente,Eduardo Sarmento
Data de Publicação: 2011
Outros Autores: Cuperschmid,Ethel Mizrahy, Campos,Tarcisio Passos Ribeiro de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500013
Resumo: This work studied the effects of β radiation of Ho-166 embedded in ceramic seeds on HeLa cells. Methodology consisted in the production of ceramic seeds with holmium-165 by sol-gel route. Chemical and physical characterizations of the seeds were performed. Subsequently, nuclear characterization was performed by gamma spectrometry. Experimental and theoretical activities were defined and initial dose rate were evaluated by MIRD (Medical Internal Radiation Dose Committee) methodology. The seeds were placed in confluent culture flasks and remained for six radionuclide half-lives. Biological results were represented by a clean 6 mm diameter area around the seed where the tumour cells were killed. The initial dose rate was 15.5 Gy. h-1. The maximum absorbed dose was 591.3 Gy. The features of the Ho-166 seeds suggested that such ceramic seeds were suitable for high dose rate brachytherapy.
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spelling Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seedsBrachytherapyceramic seedsholmiumcancer controlHeLa cellsThis work studied the effects of β radiation of Ho-166 embedded in ceramic seeds on HeLa cells. Methodology consisted in the production of ceramic seeds with holmium-165 by sol-gel route. Chemical and physical characterizations of the seeds were performed. Subsequently, nuclear characterization was performed by gamma spectrometry. Experimental and theoretical activities were defined and initial dose rate were evaluated by MIRD (Medical Internal Radiation Dose Committee) methodology. The seeds were placed in confluent culture flasks and remained for six radionuclide half-lives. Biological results were represented by a clean 6 mm diameter area around the seed where the tumour cells were killed. The initial dose rate was 15.5 Gy. h-1. The maximum absorbed dose was 591.3 Gy. The features of the Ho-166 seeds suggested that such ceramic seeds were suitable for high dose rate brachytherapy.Instituto de Tecnologia do Paraná - Tecpar2011-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500013Brazilian Archives of Biology and Technology v.54 n.5 2011reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132011000500013info:eu-repo/semantics/openAccessValente,Eduardo SarmentoCuperschmid,Ethel MizrahyCampos,Tarcisio Passos Ribeiro deeng2011-11-01T00:00:00Zoai:scielo:S1516-89132011000500013Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2011-11-01T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds
title Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds
spellingShingle Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds
Valente,Eduardo Sarmento
Brachytherapy
ceramic seeds
holmium
cancer control
HeLa cells
title_short Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds
title_full Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds
title_fullStr Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds
title_full_unstemmed Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds
title_sort Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds
author Valente,Eduardo Sarmento
author_facet Valente,Eduardo Sarmento
Cuperschmid,Ethel Mizrahy
Campos,Tarcisio Passos Ribeiro de
author_role author
author2 Cuperschmid,Ethel Mizrahy
Campos,Tarcisio Passos Ribeiro de
author2_role author
author
dc.contributor.author.fl_str_mv Valente,Eduardo Sarmento
Cuperschmid,Ethel Mizrahy
Campos,Tarcisio Passos Ribeiro de
dc.subject.por.fl_str_mv Brachytherapy
ceramic seeds
holmium
cancer control
HeLa cells
topic Brachytherapy
ceramic seeds
holmium
cancer control
HeLa cells
description This work studied the effects of β radiation of Ho-166 embedded in ceramic seeds on HeLa cells. Methodology consisted in the production of ceramic seeds with holmium-165 by sol-gel route. Chemical and physical characterizations of the seeds were performed. Subsequently, nuclear characterization was performed by gamma spectrometry. Experimental and theoretical activities were defined and initial dose rate were evaluated by MIRD (Medical Internal Radiation Dose Committee) methodology. The seeds were placed in confluent culture flasks and remained for six radionuclide half-lives. Biological results were represented by a clean 6 mm diameter area around the seed where the tumour cells were killed. The initial dose rate was 15.5 Gy. h-1. The maximum absorbed dose was 591.3 Gy. The features of the Ho-166 seeds suggested that such ceramic seeds were suitable for high dose rate brachytherapy.
publishDate 2011
dc.date.none.fl_str_mv 2011-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132011000500013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.54 n.5 2011
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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