Assessment of the plan for pre-exposition vaccination with Fuenzalida-Palacios anti-rabies vaccine

• Autor(a) principal: Preto,Angela Aparecida
• Data de Publicação: 2000
• Outros Autores: Gomes,Elisa Maines, Fernandes,Maurício José, Hennig,Nei Adolfo, Germano,Pedro Manoel Leal
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Archives of Biology and Technology
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132000000300002
• topic: Immunization; rabies vaccine; antibodies; neutralization; Fuenzalida-Palacios

Studies ere carried out to monitor the titres of anti-rabies antibodies taken from individuals exposed to the risk of infection. Fifty-seven individuals aged between 20 and 40, were vaccinated with a minimum titre of 1.3 IU Fuenzalida-Palacios type anti-rabies vaccine. The vaccination plan consisted of the application of three doses at two day intervals and a booster applied 28 days after the final dose. The accompainment of the antibody titres was achieved by means of the seroneutralization test over a total period of 18 months. Through the monitoring carried out, it was found to be necessary to apply a booster vaccination to part of the group. Some of these individuals were revaccinated with Fuenzalida-Palacios type vaccine with a minimum titre of 1.3 IU. And some with cellular vaccine with a minimum titre of 2.5 IU. All the individuals responded with titres greater than 0.5 IU, maintaining these levels until the end of the observation period, demonstrating a ready anamnestic response to both immunogens.