A model for the study of skeletal anomalies in rat fetuses

Detalhes bibliográficos
Autor(a) principal: Effting,Cristiane
Data de Publicação: 2004
Outros Autores: Paula,Daniel Jesus de, Nunes Junior,Guilhermino Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132004000100005
Resumo: The aim of this study was to validate a model of skeletal anomalies in rat fetuses by the administration of ketoconazole (80 mg/kg) to pregnant rats during organogenesis. Bones of the head, trunk and anterior and posterior limbs were examined for detection of anomalies. Statistical differences regarding the number of fetuses and postimplantation resorptions, and fetal and placental weight were significant. The frequency of skeletal anomalies in the head, trunk, and anterior and posterior limbs in the ketoconazole-treated group were also significant when compared to the control group. It could be concluded that the model suggested was valid for study of skeletal anomalies and abnormal bones development in rat fetuse, in spite of the loss of fetuses due to resorptions.
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spelling A model for the study of skeletal anomalies in rat fetusesAzol AntifungalsKetoconazoleModelsPregnancySkeletal MalformationSteroidsTeratogenesisWistar RatsThe aim of this study was to validate a model of skeletal anomalies in rat fetuses by the administration of ketoconazole (80 mg/kg) to pregnant rats during organogenesis. Bones of the head, trunk and anterior and posterior limbs were examined for detection of anomalies. Statistical differences regarding the number of fetuses and postimplantation resorptions, and fetal and placental weight were significant. The frequency of skeletal anomalies in the head, trunk, and anterior and posterior limbs in the ketoconazole-treated group were also significant when compared to the control group. It could be concluded that the model suggested was valid for study of skeletal anomalies and abnormal bones development in rat fetuse, in spite of the loss of fetuses due to resorptions.Instituto de Tecnologia do Paraná - Tecpar2004-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132004000100005Brazilian Archives of Biology and Technology v.47 n.1 2004reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132004000100005info:eu-repo/semantics/openAccessEffting,CristianePaula,Daniel Jesus deNunes Junior,Guilhermino Pereiraeng2004-07-02T00:00:00Zoai:scielo:S1516-89132004000100005Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2004-07-02T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv A model for the study of skeletal anomalies in rat fetuses
title A model for the study of skeletal anomalies in rat fetuses
spellingShingle A model for the study of skeletal anomalies in rat fetuses
Effting,Cristiane
Azol Antifungals
Ketoconazole
Models
Pregnancy
Skeletal Malformation
Steroids
Teratogenesis
Wistar Rats
title_short A model for the study of skeletal anomalies in rat fetuses
title_full A model for the study of skeletal anomalies in rat fetuses
title_fullStr A model for the study of skeletal anomalies in rat fetuses
title_full_unstemmed A model for the study of skeletal anomalies in rat fetuses
title_sort A model for the study of skeletal anomalies in rat fetuses
author Effting,Cristiane
author_facet Effting,Cristiane
Paula,Daniel Jesus de
Nunes Junior,Guilhermino Pereira
author_role author
author2 Paula,Daniel Jesus de
Nunes Junior,Guilhermino Pereira
author2_role author
author
dc.contributor.author.fl_str_mv Effting,Cristiane
Paula,Daniel Jesus de
Nunes Junior,Guilhermino Pereira
dc.subject.por.fl_str_mv Azol Antifungals
Ketoconazole
Models
Pregnancy
Skeletal Malformation
Steroids
Teratogenesis
Wistar Rats
topic Azol Antifungals
Ketoconazole
Models
Pregnancy
Skeletal Malformation
Steroids
Teratogenesis
Wistar Rats
description The aim of this study was to validate a model of skeletal anomalies in rat fetuses by the administration of ketoconazole (80 mg/kg) to pregnant rats during organogenesis. Bones of the head, trunk and anterior and posterior limbs were examined for detection of anomalies. Statistical differences regarding the number of fetuses and postimplantation resorptions, and fetal and placental weight were significant. The frequency of skeletal anomalies in the head, trunk, and anterior and posterior limbs in the ketoconazole-treated group were also significant when compared to the control group. It could be concluded that the model suggested was valid for study of skeletal anomalies and abnormal bones development in rat fetuse, in spite of the loss of fetuses due to resorptions.
publishDate 2004
dc.date.none.fl_str_mv 2004-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132004000100005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132004000100005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132004000100005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.47 n.1 2004
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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