Enhanced response of the fricke solution doped with hematoporphyrin under X-rays irradiation

Detalhes bibliográficos
Autor(a) principal: Austerlitz,Carlos
Data de Publicação: 2008
Outros Autores: Souza,Vivianne Lúcia Bormann de, Campos,Diana Maria Tavares, Kurachi,Cristina, Bagnato,Vanderley, Sibata,Cláudio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000200006
Resumo: The vials filled with Fricke solutions were doped with increasing concentrations of Photogem®, used in photodynamic therapy. These vials were then irradiated with low-energy X-rays with doses ranging from 5 to 20 Gy. The conventional Fricke solution was also irradiated with the same doses. The concentration of ferric ions for the Fricke and doped-Fricke irradiated solutions were measured in a spectrophotometer at 220 to 340 nm. The results showed that there was an enhancement in the response of the doped-Fricke solution, which was proportional to the concentration of the photosensitizer. The use of such procedure for studying the radiosensitizing property of photosensitizers based on the production of free radicals is also discussed.
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spelling Enhanced response of the fricke solution doped with hematoporphyrin under X-rays irradiationPhotodynamic therapyhematoporphyrinFricke dosimeterfree radicalsThe vials filled with Fricke solutions were doped with increasing concentrations of Photogem®, used in photodynamic therapy. These vials were then irradiated with low-energy X-rays with doses ranging from 5 to 20 Gy. The conventional Fricke solution was also irradiated with the same doses. The concentration of ferric ions for the Fricke and doped-Fricke irradiated solutions were measured in a spectrophotometer at 220 to 340 nm. The results showed that there was an enhancement in the response of the doped-Fricke solution, which was proportional to the concentration of the photosensitizer. The use of such procedure for studying the radiosensitizing property of photosensitizers based on the production of free radicals is also discussed.Instituto de Tecnologia do Paraná - Tecpar2008-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000200006Brazilian Archives of Biology and Technology v.51 n.2 2008reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132008000200006info:eu-repo/semantics/openAccessAusterlitz,CarlosSouza,Vivianne Lúcia Bormann deCampos,Diana Maria TavaresKurachi,CristinaBagnato,VanderleySibata,Cláudioeng2008-05-28T00:00:00Zoai:scielo:S1516-89132008000200006Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2008-05-28T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Enhanced response of the fricke solution doped with hematoporphyrin under X-rays irradiation
title Enhanced response of the fricke solution doped with hematoporphyrin under X-rays irradiation
spellingShingle Enhanced response of the fricke solution doped with hematoporphyrin under X-rays irradiation
Austerlitz,Carlos
Photodynamic therapy
hematoporphyrin
Fricke dosimeter
free radicals
title_short Enhanced response of the fricke solution doped with hematoporphyrin under X-rays irradiation
title_full Enhanced response of the fricke solution doped with hematoporphyrin under X-rays irradiation
title_fullStr Enhanced response of the fricke solution doped with hematoporphyrin under X-rays irradiation
title_full_unstemmed Enhanced response of the fricke solution doped with hematoporphyrin under X-rays irradiation
title_sort Enhanced response of the fricke solution doped with hematoporphyrin under X-rays irradiation
author Austerlitz,Carlos
author_facet Austerlitz,Carlos
Souza,Vivianne Lúcia Bormann de
Campos,Diana Maria Tavares
Kurachi,Cristina
Bagnato,Vanderley
Sibata,Cláudio
author_role author
author2 Souza,Vivianne Lúcia Bormann de
Campos,Diana Maria Tavares
Kurachi,Cristina
Bagnato,Vanderley
Sibata,Cláudio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Austerlitz,Carlos
Souza,Vivianne Lúcia Bormann de
Campos,Diana Maria Tavares
Kurachi,Cristina
Bagnato,Vanderley
Sibata,Cláudio
dc.subject.por.fl_str_mv Photodynamic therapy
hematoporphyrin
Fricke dosimeter
free radicals
topic Photodynamic therapy
hematoporphyrin
Fricke dosimeter
free radicals
description The vials filled with Fricke solutions were doped with increasing concentrations of Photogem®, used in photodynamic therapy. These vials were then irradiated with low-energy X-rays with doses ranging from 5 to 20 Gy. The conventional Fricke solution was also irradiated with the same doses. The concentration of ferric ions for the Fricke and doped-Fricke irradiated solutions were measured in a spectrophotometer at 220 to 340 nm. The results showed that there was an enhancement in the response of the doped-Fricke solution, which was proportional to the concentration of the photosensitizer. The use of such procedure for studying the radiosensitizing property of photosensitizers based on the production of free radicals is also discussed.
publishDate 2008
dc.date.none.fl_str_mv 2008-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000200006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000200006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132008000200006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.51 n.2 2008
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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