Overview and perspectives on the transcriptome of paracoccidioides brasiliensis
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UCB |
Texto Completo: | http://twingo.ucb.br:8080/jspui/handle/10869/625 https://repositorio.ucb.br:9443/jspui/handle/123456789/7777 |
Resumo: | Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America that affects 10 million individuals. Pathogenicity is assumed to be a consequence of the dimorphic transition from mycelium to yeast cells during human infection. This review shows the results of the P. brasiliensis transcriptome project which generated 6,022 assembled groups from mycelium and yeast phases. Computer analysis using the tools of bioinformatics revealed several aspects from the transcriptome of this pathogen such as: general and differential metabolism in mycelium and yeast cells; cell cycle, DNA replication, repair and recombination; RNA biogenesis apparatus; translation and protein fate machineries; cell wall; hydrolytic enzymes; proteases; GPI-anchored proteins; molecular chaperones; insights into drug resistance and transporters; oxidative stress response and virulence. The present analysis has provided a more comprehensive view of some specific features considered relevant for the understanding of basic and applied knowledge of P. brasiliensis. |
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Andrade, Rosângela V.Silva, Silvana P. daTorres, Fernando A. G.Poças-Fonseca, Marcio JoséSilva-Pereira, IldineteMaranhão, Andrea Q.Campos, Élida G.Moraes, Lídia Maria P.Jesuíno, Rosália S. A.Pereira, MaristelaSoares, Célia M. A.Walter, Maria Emília M. T.Carvalho, Maria José A.Almeida, Nalvo F.Brígido, Marcelo M.Felipe, Maria Sueli S.2016-10-10T03:52:38Z2016-10-10T03:52:38Z2005ANDRADE, Rosângela V. et al. Overview and perspectives on the transcriptome of Paracoccidioides brasiliensis. Revista Iberoamericana Micologia, v. 22, p. 203-212, 2005http://twingo.ucb.br:8080/jspui/handle/10869/625https://repositorio.ucb.br:9443/jspui/handle/123456789/7777Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America that affects 10 million individuals. Pathogenicity is assumed to be a consequence of the dimorphic transition from mycelium to yeast cells during human infection. This review shows the results of the P. brasiliensis transcriptome project which generated 6,022 assembled groups from mycelium and yeast phases. Computer analysis using the tools of bioinformatics revealed several aspects from the transcriptome of this pathogen such as: general and differential metabolism in mycelium and yeast cells; cell cycle, DNA replication, repair and recombination; RNA biogenesis apparatus; translation and protein fate machineries; cell wall; hydrolytic enzymes; proteases; GPI-anchored proteins; molecular chaperones; insights into drug resistance and transporters; oxidative stress response and virulence. The present analysis has provided a more comprehensive view of some specific features considered relevant for the understanding of basic and applied knowledge of P. brasiliensis.Made available in DSpace on 2016-10-10T03:52:38Z (GMT). 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dc.title.pt_BR.fl_str_mv |
Overview and perspectives on the transcriptome of paracoccidioides brasiliensis |
title |
Overview and perspectives on the transcriptome of paracoccidioides brasiliensis |
spellingShingle |
Overview and perspectives on the transcriptome of paracoccidioides brasiliensis Andrade, Rosângela V. Transcriptome Expressed sequence tags Dimorphic and thermo-regulated fungus Paracoccidioides brasiliensis |
title_short |
Overview and perspectives on the transcriptome of paracoccidioides brasiliensis |
title_full |
Overview and perspectives on the transcriptome of paracoccidioides brasiliensis |
title_fullStr |
Overview and perspectives on the transcriptome of paracoccidioides brasiliensis |
title_full_unstemmed |
Overview and perspectives on the transcriptome of paracoccidioides brasiliensis |
title_sort |
Overview and perspectives on the transcriptome of paracoccidioides brasiliensis |
author |
Andrade, Rosângela V. |
author_facet |
Andrade, Rosângela V. Silva, Silvana P. da Torres, Fernando A. G. Poças-Fonseca, Marcio José Silva-Pereira, Ildinete Maranhão, Andrea Q. Campos, Élida G. Moraes, Lídia Maria P. Jesuíno, Rosália S. A. Pereira, Maristela Soares, Célia M. A. Walter, Maria Emília M. T. Carvalho, Maria José A. Almeida, Nalvo F. Brígido, Marcelo M. Felipe, Maria Sueli S. |
author_role |
author |
author2 |
Silva, Silvana P. da Torres, Fernando A. G. Poças-Fonseca, Marcio José Silva-Pereira, Ildinete Maranhão, Andrea Q. Campos, Élida G. Moraes, Lídia Maria P. Jesuíno, Rosália S. A. Pereira, Maristela Soares, Célia M. A. Walter, Maria Emília M. T. Carvalho, Maria José A. Almeida, Nalvo F. Brígido, Marcelo M. Felipe, Maria Sueli S. |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Andrade, Rosângela V. Silva, Silvana P. da Torres, Fernando A. G. Poças-Fonseca, Marcio José Silva-Pereira, Ildinete Maranhão, Andrea Q. Campos, Élida G. Moraes, Lídia Maria P. Jesuíno, Rosália S. A. Pereira, Maristela Soares, Célia M. A. Walter, Maria Emília M. T. Carvalho, Maria José A. Almeida, Nalvo F. Brígido, Marcelo M. Felipe, Maria Sueli S. |
dc.subject.por.fl_str_mv |
Transcriptome Expressed sequence tags Dimorphic and thermo-regulated fungus Paracoccidioides brasiliensis |
topic |
Transcriptome Expressed sequence tags Dimorphic and thermo-regulated fungus Paracoccidioides brasiliensis |
dc.description.abstract.por.fl_txt_mv |
Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America that affects 10 million individuals. Pathogenicity is assumed to be a consequence of the dimorphic transition from mycelium to yeast cells during human infection. This review shows the results of the P. brasiliensis transcriptome project which generated 6,022 assembled groups from mycelium and yeast phases. Computer analysis using the tools of bioinformatics revealed several aspects from the transcriptome of this pathogen such as: general and differential metabolism in mycelium and yeast cells; cell cycle, DNA replication, repair and recombination; RNA biogenesis apparatus; translation and protein fate machineries; cell wall; hydrolytic enzymes; proteases; GPI-anchored proteins; molecular chaperones; insights into drug resistance and transporters; oxidative stress response and virulence. The present analysis has provided a more comprehensive view of some specific features considered relevant for the understanding of basic and applied knowledge of P. brasiliensis. |
dc.description.version.pt_BR.fl_txt_mv |
Sim |
dc.description.status.pt_BR.fl_txt_mv |
Publicado |
description |
Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America that affects 10 million individuals. Pathogenicity is assumed to be a consequence of the dimorphic transition from mycelium to yeast cells during human infection. This review shows the results of the P. brasiliensis transcriptome project which generated 6,022 assembled groups from mycelium and yeast phases. Computer analysis using the tools of bioinformatics revealed several aspects from the transcriptome of this pathogen such as: general and differential metabolism in mycelium and yeast cells; cell cycle, DNA replication, repair and recombination; RNA biogenesis apparatus; translation and protein fate machineries; cell wall; hydrolytic enzymes; proteases; GPI-anchored proteins; molecular chaperones; insights into drug resistance and transporters; oxidative stress response and virulence. The present analysis has provided a more comprehensive view of some specific features considered relevant for the understanding of basic and applied knowledge of P. brasiliensis. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005 |
dc.date.accessioned.fl_str_mv |
2016-10-10T03:52:38Z |
dc.date.available.fl_str_mv |
2016-10-10T03:52:38Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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publishedVersion |
format |
article |
dc.identifier.citation.fl_str_mv |
ANDRADE, Rosângela V. et al. Overview and perspectives on the transcriptome of Paracoccidioides brasiliensis. Revista Iberoamericana Micologia, v. 22, p. 203-212, 2005 |
dc.identifier.uri.fl_str_mv |
http://twingo.ucb.br:8080/jspui/handle/10869/625 https://repositorio.ucb.br:9443/jspui/handle/123456789/7777 |
identifier_str_mv |
ANDRADE, Rosângela V. et al. Overview and perspectives on the transcriptome of Paracoccidioides brasiliensis. Revista Iberoamericana Micologia, v. 22, p. 203-212, 2005 |
url |
http://twingo.ucb.br:8080/jspui/handle/10869/625 https://repositorio.ucb.br:9443/jspui/handle/123456789/7777 |
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eng |
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eng |
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openAccess |
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Repositório Institucional da UCB |
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