SÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE LIBERAÇÃO IN VITRO DE IBUPROFENATO INTERCALADO EM HIDRÓXIDOS DUPLOS LAMELARES DISPERSOS EM MEMBRANAS DE QUITOSANA/ALGINATO
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UNICENTRO |
Texto Completo: | http://tede.unicentro.br:8080/jspui/handle/jspui/1578 |
Resumo: | The layered double hydroxides (LDH) of Zn/Al in molar ratio 2:1 and 3:1 intercalated with the drug Ibuprofen (pharmacological grade reagent) were synthesized by the co-precipitation method at constant pH. These layered compounds were characterized by the XRD, FTIR and TGA/DSC instrumental techniques, which have shown the formation of the LDH containing the drug intercalated by the displacement to smaller angles in 2θ of the basal peak referring to the plane (003) and by the presence of the peaks referring to the (012) and (110), characteristic for layered compounds, observed by the XRD technique, characteristic stretching and bending deformations for the intercalated drug was observed by the FTIR technique, and it was possible to estimate the general formula for the LDH obtained through the results of TGA/DSC. After the LDH/IBU was characterized, the in vitro release of LDH in distilled water and phosphate buffer solution (PBS) were performed, where was observed the slower release of the drug into the medium. Thus, the synthesized LDH were added to the chitosan/alginate membranes, where the chitosan used was pharmacological grade, aiming at the use of low-cost reagents. In the in vitro release tests of the LDH contained in the membranes, it was possible to observe an increase in the insolubility of the drug that is intercalated in the interlayer space of these LDH, this increase in insolubility observed because the percentage of drug release was lower than the percentage of release of the drug in the free samples and visually by the translucency of the membranes. Thus, the following percentages of release 15,48% and 17,5% of the drug in water and 23,22% and 26,25% of the drug in PBS buffer respectively for the membranes samples containing the LDH Zn/Al-IBU 2:1 and Zn/Al-IBU 3:1. Thus, the synthesized hybrid membranes (chitosan/alginate - LDH-Ibuprofen) are very promising in the application as alloplastic bone graft with controlled release of drugs. |
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Marangoni, Rafaelhttp://lattes.cnpq.br/2308700333314623Danczuk, Marinshttp://lattes.cnpq.br/7546279824764535085640729-12http://lattes.cnpq.br/7071868404889372Machado, Monielly Viomar2021-04-30T12:39:54Z2019-02-22Machado, Monielly Viomar. SÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE LIBERAÇÃO IN VITRO DE IBUPROFENATO INTERCALADO EM HIDRÓXIDOS DUPLOS LAMELARES DISPERSOS EM MEMBRANAS DE QUITOSANA/ALGINATO. 2019. 94 f. Dissertação (Programa de Pós-Graduação em Química - Mestrado) - Universidade Estadual do Centro-Oeste, Guarapuava-PR.http://tede.unicentro.br:8080/jspui/handle/jspui/1578The layered double hydroxides (LDH) of Zn/Al in molar ratio 2:1 and 3:1 intercalated with the drug Ibuprofen (pharmacological grade reagent) were synthesized by the co-precipitation method at constant pH. These layered compounds were characterized by the XRD, FTIR and TGA/DSC instrumental techniques, which have shown the formation of the LDH containing the drug intercalated by the displacement to smaller angles in 2θ of the basal peak referring to the plane (003) and by the presence of the peaks referring to the (012) and (110), characteristic for layered compounds, observed by the XRD technique, characteristic stretching and bending deformations for the intercalated drug was observed by the FTIR technique, and it was possible to estimate the general formula for the LDH obtained through the results of TGA/DSC. After the LDH/IBU was characterized, the in vitro release of LDH in distilled water and phosphate buffer solution (PBS) were performed, where was observed the slower release of the drug into the medium. Thus, the synthesized LDH were added to the chitosan/alginate membranes, where the chitosan used was pharmacological grade, aiming at the use of low-cost reagents. In the in vitro release tests of the LDH contained in the membranes, it was possible to observe an increase in the insolubility of the drug that is intercalated in the interlayer space of these LDH, this increase in insolubility observed because the percentage of drug release was lower than the percentage of release of the drug in the free samples and visually by the translucency of the membranes. Thus, the following percentages of release 15,48% and 17,5% of the drug in water and 23,22% and 26,25% of the drug in PBS buffer respectively for the membranes samples containing the LDH Zn/Al-IBU 2:1 and Zn/Al-IBU 3:1. Thus, the synthesized hybrid membranes (chitosan/alginate - LDH-Ibuprofen) are very promising in the application as alloplastic bone graft with controlled release of drugs.Os hidróxidos duplos lamelares (HDLs) de Zn/Al nas razões molares 2:1 e 3:1 intercalados com o fármaco Ibuprofeno (reagente de grau farmacológico) foram sintetizados pelo método de co-precipitação a pH constante. Esses compostos lamelares foram caracterizados pelas técnicas instrumentais DRX, FTIR e TGA/DSC, as quais comprovaram a formação dos HDLs contendo o fármaco intercalado pelo deslocamento para menores ângulos em 2θ do pico basal referente ao plano (003) e pela presença dos picos referentes aos planos (012) e (110), característicos para compostos lamelares observados pela técnica de DRX, estiramentos e deformações angulares característicos do fármaco que se encontra intercalado observado pela técnica de FTIR e foi possível estimar a fórmula geral dos HDLs obtidos através dos resultados de TGA/DSC. Depois de devidamente caracterizados, foram realizados testes de liberação in vitro dos HDLs nos meios de água destilada e solução tampão fosfato (PBS), onde foi possível observar a liberação mais lenta do fármaco para o meio. Assim, os HDLs sintetizados foram adicionados às membranas de quitosana/alginato, sendo a quitosana utilizada de grau farmacológico, visando a utilização de reagentes de baixo custo. Nos testes de liberação in vitro dos HDLs contidos nas membranas, foi possível observar aumento na insolubilidade do fármaco que se encontra intercalado no espaço interlamelar desses HDLs, sendo esse aumento na insolubilidade observado na porcentagem de liberação do fármaco ser inferior à porcentagem de liberação do fármaco nas amostras livres e visualmente pela translucidez das membranas. Foram obtidas as seguintes porcentagens de liberação 15,48 % e 17,5 % do fármaco em água, e 23,22 % e 26,25 % do fármaco em solução tampão PBS, respectivamente para as amostras das membranas contendo os HDLs Zn/Al-IBU 2:1 e Zn/Al-IBU 3:1. Sendo assim, as membranas híbridas sintetizadas (quitosana/alginato – HDLs-Ibuprofeno) são bastante promissoras na aplicação como enxerto ósseo aloplástico com liberação lenta de fármacos.Submitted by Fabiano Jucá (fjuca@unicentro.br) on 2021-04-30T12:39:54Z No. of bitstreams: 1 DISSERTAÇÃO MONIELLY VIOMAR MACHADO.pdf: 6382957 bytes, checksum: 867245d4957604440bfda71fa412dcec (MD5)Made available in DSpace on 2021-04-30T12:39:54Z (GMT). No. of bitstreams: 1 DISSERTAÇÃO MONIELLY VIOMAR MACHADO.pdf: 6382957 bytes, checksum: 867245d4957604440bfda71fa412dcec (MD5) Previous issue date: 2019-02-22Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfhttp://tede.unicentro.br:8080/jspui/retrieve/6465/DISSERTA%c3%87%c3%83O%20MONIELLY%20VIOMAR%20MACHADO.pdf.jpghttp://tede.unicentro.br:8080/jspui/retrieve/6467/DISSERTA%c3%87%c3%83O%20MONIELLY%20VIOMAR%20MACHADO.pdf.jpgporUniversidade Estadual do Centro-OestePrograma de Pós-Graduação em Química (Mestrado)UNICENTROBrasilUnicentro::Departamento de Ciências Exatas e de TecnologiaHidróxidos duplos lamelaresbiomateriais poliméricosmembranas híbridasliberação controlada de fármacosibuprofenoLayered double hydroxidespolymeric biomaterialshybrid membranescontrolled release of drugsibuprofenCIENCIAS EXATAS E DA TERRA::QUIMICASÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE LIBERAÇÃO IN VITRO DE IBUPROFENATO INTERCALADO EM HIDRÓXIDOS DUPLOS LAMELARES DISPERSOS EM MEMBRANAS DE QUITOSANA/ALGINATOinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-5600948132407545169600600600600-433806549027752903315717003253031171952075167498588264571info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UNICENTROinstname:Universidade Estadual do Centro-Oeste (UNICENTRO)instacron:UNICENTROTHUMBNAILDISSERTAÇÃO MONIELLY VIOMAR MACHADO.pdf.jpgDISSERTAÇÃO MONIELLY VIOMAR MACHADO.pdf.jpgimage/jpeg1943http://localhost:8080/tede/bitstream/jspui/1578/4/DISSERTA%C3%87%C3%83O+MONIELLY+VIOMAR+MACHADO.pdf.jpgcc73c4c239a4c332d642ba1e7c7a9fb2MD54TEXTDISSERTAÇÃO MONIELLY VIOMAR MACHADO.pdf.txtDISSERTAÇÃO MONIELLY VIOMAR MACHADO.pdf.txttext/plain132094http://localhost:8080/tede/bitstream/jspui/1578/3/DISSERTA%C3%87%C3%83O+MONIELLY+VIOMAR+MACHADO.pdf.txtd74ad8505c8fac84cdb1f1cc864cde06MD53THUMBNAILDISSERTAÇÃO MONIELLY VIOMAR MACHADO.pdf.jpgDISSERTAÇÃO MONIELLY VIOMAR MACHADO.pdf.jpgimage/jpeg1943http://localhost:8080/tede/bitstream/jspui/1578/4/DISSERTA%C3%87%C3%83O+MONIELLY+VIOMAR+MACHADO.pdf.jpgcc73c4c239a4c332d642ba1e7c7a9fb2MD54TEXTDISSERTAÇÃO MONIELLY VIOMAR MACHADO.pdf.txtDISSERTAÇÃO MONIELLY VIOMAR MACHADO.pdf.txttext/plain132094http://localhost:8080/tede/bitstream/jspui/1578/3/DISSERTA%C3%87%C3%83O+MONIELLY+VIOMAR+MACHADO.pdf.txtd74ad8505c8fac84cdb1f1cc864cde06MD53ORIGINALDISSERTAÇÃO MONIELLY VIOMAR MACHADO.pdfDISSERTAÇÃO MONIELLY VIOMAR MACHADO.pdfapplication/pdf6382957http://localhost:8080/tede/bitstream/jspui/1578/2/DISSERTA%C3%87%C3%83O+MONIELLY+VIOMAR+MACHADO.pdf867245d4957604440bfda71fa412dcecMD52LICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
SÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE LIBERAÇÃO IN VITRO DE IBUPROFENATO INTERCALADO EM HIDRÓXIDOS DUPLOS LAMELARES DISPERSOS EM MEMBRANAS DE QUITOSANA/ALGINATO |
title |
SÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE LIBERAÇÃO IN VITRO DE IBUPROFENATO INTERCALADO EM HIDRÓXIDOS DUPLOS LAMELARES DISPERSOS EM MEMBRANAS DE QUITOSANA/ALGINATO |
spellingShingle |
SÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE LIBERAÇÃO IN VITRO DE IBUPROFENATO INTERCALADO EM HIDRÓXIDOS DUPLOS LAMELARES DISPERSOS EM MEMBRANAS DE QUITOSANA/ALGINATO Machado, Monielly Viomar Hidróxidos duplos lamelares biomateriais poliméricos membranas híbridas liberação controlada de fármacos ibuprofeno Layered double hydroxides polymeric biomaterials hybrid membranes controlled release of drugs ibuprofen CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
SÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE LIBERAÇÃO IN VITRO DE IBUPROFENATO INTERCALADO EM HIDRÓXIDOS DUPLOS LAMELARES DISPERSOS EM MEMBRANAS DE QUITOSANA/ALGINATO |
title_full |
SÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE LIBERAÇÃO IN VITRO DE IBUPROFENATO INTERCALADO EM HIDRÓXIDOS DUPLOS LAMELARES DISPERSOS EM MEMBRANAS DE QUITOSANA/ALGINATO |
title_fullStr |
SÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE LIBERAÇÃO IN VITRO DE IBUPROFENATO INTERCALADO EM HIDRÓXIDOS DUPLOS LAMELARES DISPERSOS EM MEMBRANAS DE QUITOSANA/ALGINATO |
title_full_unstemmed |
SÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE LIBERAÇÃO IN VITRO DE IBUPROFENATO INTERCALADO EM HIDRÓXIDOS DUPLOS LAMELARES DISPERSOS EM MEMBRANAS DE QUITOSANA/ALGINATO |
title_sort |
SÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE LIBERAÇÃO IN VITRO DE IBUPROFENATO INTERCALADO EM HIDRÓXIDOS DUPLOS LAMELARES DISPERSOS EM MEMBRANAS DE QUITOSANA/ALGINATO |
author |
Machado, Monielly Viomar |
author_facet |
Machado, Monielly Viomar |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Marangoni, Rafael |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/2308700333314623 |
dc.contributor.advisor-co1.fl_str_mv |
Danczuk, Marins |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/7546279824764535 |
dc.contributor.authorID.fl_str_mv |
085640729-12 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/7071868404889372 |
dc.contributor.author.fl_str_mv |
Machado, Monielly Viomar |
contributor_str_mv |
Marangoni, Rafael Danczuk, Marins |
dc.subject.por.fl_str_mv |
Hidróxidos duplos lamelares biomateriais poliméricos membranas híbridas liberação controlada de fármacos ibuprofeno |
topic |
Hidróxidos duplos lamelares biomateriais poliméricos membranas híbridas liberação controlada de fármacos ibuprofeno Layered double hydroxides polymeric biomaterials hybrid membranes controlled release of drugs ibuprofen CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Layered double hydroxides polymeric biomaterials hybrid membranes controlled release of drugs ibuprofen |
dc.subject.cnpq.fl_str_mv |
CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
The layered double hydroxides (LDH) of Zn/Al in molar ratio 2:1 and 3:1 intercalated with the drug Ibuprofen (pharmacological grade reagent) were synthesized by the co-precipitation method at constant pH. These layered compounds were characterized by the XRD, FTIR and TGA/DSC instrumental techniques, which have shown the formation of the LDH containing the drug intercalated by the displacement to smaller angles in 2θ of the basal peak referring to the plane (003) and by the presence of the peaks referring to the (012) and (110), characteristic for layered compounds, observed by the XRD technique, characteristic stretching and bending deformations for the intercalated drug was observed by the FTIR technique, and it was possible to estimate the general formula for the LDH obtained through the results of TGA/DSC. After the LDH/IBU was characterized, the in vitro release of LDH in distilled water and phosphate buffer solution (PBS) were performed, where was observed the slower release of the drug into the medium. Thus, the synthesized LDH were added to the chitosan/alginate membranes, where the chitosan used was pharmacological grade, aiming at the use of low-cost reagents. In the in vitro release tests of the LDH contained in the membranes, it was possible to observe an increase in the insolubility of the drug that is intercalated in the interlayer space of these LDH, this increase in insolubility observed because the percentage of drug release was lower than the percentage of release of the drug in the free samples and visually by the translucency of the membranes. Thus, the following percentages of release 15,48% and 17,5% of the drug in water and 23,22% and 26,25% of the drug in PBS buffer respectively for the membranes samples containing the LDH Zn/Al-IBU 2:1 and Zn/Al-IBU 3:1. Thus, the synthesized hybrid membranes (chitosan/alginate - LDH-Ibuprofen) are very promising in the application as alloplastic bone graft with controlled release of drugs. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-02-22 |
dc.date.accessioned.fl_str_mv |
2021-04-30T12:39:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Machado, Monielly Viomar. SÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE LIBERAÇÃO IN VITRO DE IBUPROFENATO INTERCALADO EM HIDRÓXIDOS DUPLOS LAMELARES DISPERSOS EM MEMBRANAS DE QUITOSANA/ALGINATO. 2019. 94 f. Dissertação (Programa de Pós-Graduação em Química - Mestrado) - Universidade Estadual do Centro-Oeste, Guarapuava-PR. |
dc.identifier.uri.fl_str_mv |
http://tede.unicentro.br:8080/jspui/handle/jspui/1578 |
identifier_str_mv |
Machado, Monielly Viomar. SÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE LIBERAÇÃO IN VITRO DE IBUPROFENATO INTERCALADO EM HIDRÓXIDOS DUPLOS LAMELARES DISPERSOS EM MEMBRANAS DE QUITOSANA/ALGINATO. 2019. 94 f. Dissertação (Programa de Pós-Graduação em Química - Mestrado) - Universidade Estadual do Centro-Oeste, Guarapuava-PR. |
url |
http://tede.unicentro.br:8080/jspui/handle/jspui/1578 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
-5600948132407545169 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-4338065490277529033 |
dc.relation.cnpq.fl_str_mv |
1571700325303117195 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual do Centro-Oeste |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Química (Mestrado) |
dc.publisher.initials.fl_str_mv |
UNICENTRO |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Unicentro::Departamento de Ciências Exatas e de Tecnologia |
publisher.none.fl_str_mv |
Universidade Estadual do Centro-Oeste |
dc.source.none.fl_str_mv |
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instname_str |
Universidade Estadual do Centro-Oeste (UNICENTRO) |
instacron_str |
UNICENTRO |
institution |
UNICENTRO |
reponame_str |
Biblioteca Digital de Teses e Dissertações do UNICENTRO |
collection |
Biblioteca Digital de Teses e Dissertações do UNICENTRO |
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Biblioteca Digital de Teses e Dissertações do UNICENTRO - Universidade Estadual do Centro-Oeste (UNICENTRO) |
repository.mail.fl_str_mv |
repositorio@unicentro.br||fabianoqueiroz@yahoo.com.br |
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