Effects of nitrous oxide on cardiovascular parameters in pigs anesthetized with propofol and subjected to pressure-controlled ventilation
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/23009 |
Resumo: | This paper evaluated the effects of the ratio of nitrous oxide to oxygen (50% of each) on cardiovascular parameters in pigs anesthetized with propofol and maintained in ventilation with intermittent positive pressure. Sixteen Large White pigs, weighing between 15 and 20 kg, were divided into two groups of eight animals, and designated as follows: GPN (propofol/nitrous oxide) and GPA (propofol/compressed air). In order to allow endotracheal intubation, the animals received azaperone (2 mg kg-1, IM) followed, after 20 minutes, by intravenous propofol. After successful intubation, continuous infusion of propofol was initiated at a dose of 0.4 mg kg-1minute-1. From this point, the GPN group received N2O (diluted in 50% oxygen), while the GPA group received compressed air (diluted in 50% oxygen). Rocuronium was then administered by continuous intravenous infusion at 0.6 mg kg-1h-1. Pressure-controlled ventilation (PCV) was started and adjusted to 15 cmH2O, and the respiratory rate was set to reach capnometry readings between 35-45 mmHg. The measurement of parameters (heart rate, mean arterial pressure, cardiac index, systemic vascular resistance index, stroke index) begun 15 minutes after the administration of rocuronium, and was repeated in 15-minute intervals for 60 minutes. Data were statistically analyzed by ANOVA followed by Bonferroni test. The results showed that the 1:1 ratio combination of nitrous oxide to oxygen (50% each) did not alter the mentioned parameters in pigs anesthetized with propofol and maintained at pressure-controlled ventilation, indicating that it is a safe protocol for the cardiovascular system. |
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Semina. Ciências Agrárias (Online) |
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Effects of nitrous oxide on cardiovascular parameters in pigs anesthetized with propofol and subjected to pressure-controlled ventilationEfeitos do óxido nitroso sobre parâmetros cardiovasculares em suínos anestesiados com propofol e mantidos em ventilação controlada à pressãoBalanced anesthesiaCardiac indexHemodynamic monitoring.Anestesia balanceadaÍndice cardíacoMonitoração hemodinâmica.This paper evaluated the effects of the ratio of nitrous oxide to oxygen (50% of each) on cardiovascular parameters in pigs anesthetized with propofol and maintained in ventilation with intermittent positive pressure. Sixteen Large White pigs, weighing between 15 and 20 kg, were divided into two groups of eight animals, and designated as follows: GPN (propofol/nitrous oxide) and GPA (propofol/compressed air). In order to allow endotracheal intubation, the animals received azaperone (2 mg kg-1, IM) followed, after 20 minutes, by intravenous propofol. After successful intubation, continuous infusion of propofol was initiated at a dose of 0.4 mg kg-1minute-1. From this point, the GPN group received N2O (diluted in 50% oxygen), while the GPA group received compressed air (diluted in 50% oxygen). Rocuronium was then administered by continuous intravenous infusion at 0.6 mg kg-1h-1. Pressure-controlled ventilation (PCV) was started and adjusted to 15 cmH2O, and the respiratory rate was set to reach capnometry readings between 35-45 mmHg. The measurement of parameters (heart rate, mean arterial pressure, cardiac index, systemic vascular resistance index, stroke index) begun 15 minutes after the administration of rocuronium, and was repeated in 15-minute intervals for 60 minutes. Data were statistically analyzed by ANOVA followed by Bonferroni test. The results showed that the 1:1 ratio combination of nitrous oxide to oxygen (50% each) did not alter the mentioned parameters in pigs anesthetized with propofol and maintained at pressure-controlled ventilation, indicating that it is a safe protocol for the cardiovascular system.Objetivou-se com este trabalho avaliar os efeitos da associação de óxido nitroso (N2O) ao oxigênio, na proporção de 50% cada, sobre os parâmetros cardiovasculares em suínos anestesiados com propofol e mantidos em ventilação com pressão positiva intermitente. Para isso, foram utilizados 16 suínos da raça Large White com pesos entre 15 e 20 kg, distribuídos em dois grupos de oito animais cada, assim nomeados: GPN (GrupoPropofol/Óxidonitroso) e GPA (GrupoPropofol/Arcomprimido). Os animais receberam azaperona (2mgkg-1,IM) e após 20 minutos, administrou-se propofol por via intravenosa, em doses suficientes para permitir a intubação traqueal. Após intubação, iniciou-se a infusão contínua de propofol na dose de 0,4mgkg-1minuto-1. A partir deste momento, os animais do GPN receberam N2O diluído em 50% de oxigênio e os do GPA, ar comprimido diluído em 50% de oxigênio. Ato contínuo, administrou-se, por infusão intravenosa contínua, rocurônio a 0,6mgkg-1h-1. A ventilação controlada a pressão (VCP) foi iniciada e ajustada a 15cmH2O e a freqüência respiratória foi regulada para alcançar valores de capnometria entre 35-45mmHg. A medição dos parâmetros (freqüência cardíaca, pressão arterial média, índice cardíaco, índice da resistência periférica total, índice sistólico) iniciou-se após 15 minutos da administração de rocurônio, repetindo-se a cada 15 minutos, durante um intervalo de 60 minutos. Os dados foram submetidos à análise estatística pela ANOVA seguida pelo teste de Bonferroni. Os resultados mostraram que a associação do óxido nitroso ao oxigênio na proporção de 50% cada em suíno anestesiado com propofol e mantido em ventilação controlada à pressão não provoca alterações cardiovasculares clinicamente relevantes.UEL2017-08-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por paresEnsaio experimentalapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2300910.5433/1679-0359.2017v38n4p2209Semina: Ciências Agrárias; Vol. 38 No. 4 (2017); 2209-2214Semina: Ciências Agrárias; v. 38 n. 4 (2017); 2209-22141679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/23009/21396http://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessCarneiro, Rodrigo LimaLopes, Patrícia Cristina FerroGering, Ana PaulaBiteli, Eliselle Gouveia de FariaSilva, Paloma do Espírito SantoIdo, Cléber KazuoSilva, Helen Roberta Amaral daYamada, Diego IwaoNunes, Newton2022-10-24T12:59:20Zoai:ojs.pkp.sfu.ca:article/23009Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-10-24T12:59:20Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
Effects of nitrous oxide on cardiovascular parameters in pigs anesthetized with propofol and subjected to pressure-controlled ventilation Efeitos do óxido nitroso sobre parâmetros cardiovasculares em suínos anestesiados com propofol e mantidos em ventilação controlada à pressão |
title |
Effects of nitrous oxide on cardiovascular parameters in pigs anesthetized with propofol and subjected to pressure-controlled ventilation |
spellingShingle |
Effects of nitrous oxide on cardiovascular parameters in pigs anesthetized with propofol and subjected to pressure-controlled ventilation Carneiro, Rodrigo Lima Balanced anesthesia Cardiac index Hemodynamic monitoring. Anestesia balanceada Índice cardíaco Monitoração hemodinâmica. |
title_short |
Effects of nitrous oxide on cardiovascular parameters in pigs anesthetized with propofol and subjected to pressure-controlled ventilation |
title_full |
Effects of nitrous oxide on cardiovascular parameters in pigs anesthetized with propofol and subjected to pressure-controlled ventilation |
title_fullStr |
Effects of nitrous oxide on cardiovascular parameters in pigs anesthetized with propofol and subjected to pressure-controlled ventilation |
title_full_unstemmed |
Effects of nitrous oxide on cardiovascular parameters in pigs anesthetized with propofol and subjected to pressure-controlled ventilation |
title_sort |
Effects of nitrous oxide on cardiovascular parameters in pigs anesthetized with propofol and subjected to pressure-controlled ventilation |
author |
Carneiro, Rodrigo Lima |
author_facet |
Carneiro, Rodrigo Lima Lopes, Patrícia Cristina Ferro Gering, Ana Paula Biteli, Eliselle Gouveia de Faria Silva, Paloma do Espírito Santo Ido, Cléber Kazuo Silva, Helen Roberta Amaral da Yamada, Diego Iwao Nunes, Newton |
author_role |
author |
author2 |
Lopes, Patrícia Cristina Ferro Gering, Ana Paula Biteli, Eliselle Gouveia de Faria Silva, Paloma do Espírito Santo Ido, Cléber Kazuo Silva, Helen Roberta Amaral da Yamada, Diego Iwao Nunes, Newton |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Carneiro, Rodrigo Lima Lopes, Patrícia Cristina Ferro Gering, Ana Paula Biteli, Eliselle Gouveia de Faria Silva, Paloma do Espírito Santo Ido, Cléber Kazuo Silva, Helen Roberta Amaral da Yamada, Diego Iwao Nunes, Newton |
dc.subject.por.fl_str_mv |
Balanced anesthesia Cardiac index Hemodynamic monitoring. Anestesia balanceada Índice cardíaco Monitoração hemodinâmica. |
topic |
Balanced anesthesia Cardiac index Hemodynamic monitoring. Anestesia balanceada Índice cardíaco Monitoração hemodinâmica. |
description |
This paper evaluated the effects of the ratio of nitrous oxide to oxygen (50% of each) on cardiovascular parameters in pigs anesthetized with propofol and maintained in ventilation with intermittent positive pressure. Sixteen Large White pigs, weighing between 15 and 20 kg, were divided into two groups of eight animals, and designated as follows: GPN (propofol/nitrous oxide) and GPA (propofol/compressed air). In order to allow endotracheal intubation, the animals received azaperone (2 mg kg-1, IM) followed, after 20 minutes, by intravenous propofol. After successful intubation, continuous infusion of propofol was initiated at a dose of 0.4 mg kg-1minute-1. From this point, the GPN group received N2O (diluted in 50% oxygen), while the GPA group received compressed air (diluted in 50% oxygen). Rocuronium was then administered by continuous intravenous infusion at 0.6 mg kg-1h-1. Pressure-controlled ventilation (PCV) was started and adjusted to 15 cmH2O, and the respiratory rate was set to reach capnometry readings between 35-45 mmHg. The measurement of parameters (heart rate, mean arterial pressure, cardiac index, systemic vascular resistance index, stroke index) begun 15 minutes after the administration of rocuronium, and was repeated in 15-minute intervals for 60 minutes. Data were statistically analyzed by ANOVA followed by Bonferroni test. The results showed that the 1:1 ratio combination of nitrous oxide to oxygen (50% each) did not alter the mentioned parameters in pigs anesthetized with propofol and maintained at pressure-controlled ventilation, indicating that it is a safe protocol for the cardiovascular system. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-08-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avaliado por pares Ensaio experimental |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/23009 10.5433/1679-0359.2017v38n4p2209 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/23009 |
identifier_str_mv |
10.5433/1679-0359.2017v38n4p2209 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/23009/21396 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 38 No. 4 (2017); 2209-2214 Semina: Ciências Agrárias; v. 38 n. 4 (2017); 2209-2214 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
_version_ |
1750315423099781120 |