Idiopathic hypereosinophilic syndrome in a rottweiler: a case report
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259 |
Resumo: | Eosinophils are cells of the immune system that have several important functions including phagocytosis of microorganisms, antigen presentation, contribution to chronic inflammation, and immunity against parasites. The hypereosinophilic syndrome (HES) is a rare disease in humans that is characterized by persistent eosinophilia (over six months) and variable eosinophil infiltration in organs such as the lungs, spleen, liver, lymph nodes, bone marrow, and gastrointestinal tract. Once in the tissues, these cells can cause damage by various mechanisms such as release of cytotoxic oxygen free radical and proteins. No etiology has yet been established for HES. The clinical signs vary and relate to the organs involved. In veterinary medicine, the disease has been described in cats, but rarely in dogs, with Rottweilers apparently more predisposed to developing the disease. Owing to the small number of cases reported in the veterinary literature, the prognosis of this disease and the most appropriate treatment options are unclear. Although it can be fatal in animals showing severe clinical symptoms, spontaneous remission may also occur. This study reports a case of HES in a Rottweiler in which the predominant clinical sign was abdominal effusion. We discuss the clinical and laboratory aspects of the disease. |
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Semina. Ciências Agrárias (Online) |
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Idiopathic hypereosinophilic syndrome in a rottweiler: a case reportSíndrome hipereosinofílica idiopática do rottweiler: relato de casoAbdominal effusionDogEosinophils.CãoEfusão abdominalEosinófilos.Eosinophils are cells of the immune system that have several important functions including phagocytosis of microorganisms, antigen presentation, contribution to chronic inflammation, and immunity against parasites. The hypereosinophilic syndrome (HES) is a rare disease in humans that is characterized by persistent eosinophilia (over six months) and variable eosinophil infiltration in organs such as the lungs, spleen, liver, lymph nodes, bone marrow, and gastrointestinal tract. Once in the tissues, these cells can cause damage by various mechanisms such as release of cytotoxic oxygen free radical and proteins. No etiology has yet been established for HES. The clinical signs vary and relate to the organs involved. In veterinary medicine, the disease has been described in cats, but rarely in dogs, with Rottweilers apparently more predisposed to developing the disease. Owing to the small number of cases reported in the veterinary literature, the prognosis of this disease and the most appropriate treatment options are unclear. Although it can be fatal in animals showing severe clinical symptoms, spontaneous remission may also occur. This study reports a case of HES in a Rottweiler in which the predominant clinical sign was abdominal effusion. We discuss the clinical and laboratory aspects of the disease.Os eosinófilos são células do sistema imunológico que tem importantes funções, tais como fagocitose de micro-organismos, apresentação de antígenos, contribuição para a cronicidade do processo inflamatório e imunidade contra parasitas. A síndrome hipereosinofílica (SHE) é uma enfermidade rara que acomete seres humanos, caracterizada por eosinofilia periférica persistente (acima de seis meses) e infiltração variável de eosinófilos em diferentes órgãos, como pulmão, baço, fígado, linfonodos, medula óssea e o trato gastrointestinal. Uma vez nos tecidos, essas células causam danos por diversos mecanismos, como liberação de proteínas citotóxicas e radicais livres de oxigênio. Não é possível identificar uma etiologia nos casos de SHE. Os sinais clínicos são varáveis, e diretamente relacionados com os órgãos acometidos. Em medicina veterinária, a moléstia já foi descrita em felinos, mas raramente em cães, sendo que animais da raça Rottweiler são mais predispostos ao desenvolvimento da doença. Em função do pequeno número de casos descritos na literatura veterinária, a evolução da doença e as opções mais apropriadas de tratamento são pouco conhecidas. Embora alguns animais apresentem sinais clínicos graves, podendo evoluir para o óbito, a remissão espontânea também pode ocorrer. O presente trabalho tem por objetivo relatar um caso de SHE com sinal clínico predominante de efusão abdominal em um filhote de cão da raça Rottweiler, abordando aspectos clínicos e laboratoriais da enfermidade.UEL2017-03-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfimage/jpegimage/jpegimage/jpegapplication/pdfapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2125910.5433/1679-0359.2017v38n1p311Semina: Ciências Agrárias; Vol. 38 No. 1 (2017); 311-316Semina: Ciências Agrárias; v. 38 n. 1 (2017); 311-3161679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELengporhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259/20611https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259/35637https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259/35638https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259/35639https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259/35640https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259/38826Ferian, Paulo EduardoBach, Eloisa CarlaSalbego, Fabiano ZanineMadaloz, Lusiane ZorziVolpato, JulietaMuller, Thiago RinaldiCarneiro, Rubens Antônioinfo:eu-repo/semantics/openAccess2017-03-06T11:32:48Zoai:ojs.pkp.sfu.ca:article/21259Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2017-03-06T11:32:48Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
Idiopathic hypereosinophilic syndrome in a rottweiler: a case report Síndrome hipereosinofílica idiopática do rottweiler: relato de caso |
title |
Idiopathic hypereosinophilic syndrome in a rottweiler: a case report |
spellingShingle |
Idiopathic hypereosinophilic syndrome in a rottweiler: a case report Ferian, Paulo Eduardo Abdominal effusion Dog Eosinophils. Cão Efusão abdominal Eosinófilos. |
title_short |
Idiopathic hypereosinophilic syndrome in a rottweiler: a case report |
title_full |
Idiopathic hypereosinophilic syndrome in a rottweiler: a case report |
title_fullStr |
Idiopathic hypereosinophilic syndrome in a rottweiler: a case report |
title_full_unstemmed |
Idiopathic hypereosinophilic syndrome in a rottweiler: a case report |
title_sort |
Idiopathic hypereosinophilic syndrome in a rottweiler: a case report |
author |
Ferian, Paulo Eduardo |
author_facet |
Ferian, Paulo Eduardo Bach, Eloisa Carla Salbego, Fabiano Zanine Madaloz, Lusiane Zorzi Volpato, Julieta Muller, Thiago Rinaldi Carneiro, Rubens Antônio |
author_role |
author |
author2 |
Bach, Eloisa Carla Salbego, Fabiano Zanine Madaloz, Lusiane Zorzi Volpato, Julieta Muller, Thiago Rinaldi Carneiro, Rubens Antônio |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Ferian, Paulo Eduardo Bach, Eloisa Carla Salbego, Fabiano Zanine Madaloz, Lusiane Zorzi Volpato, Julieta Muller, Thiago Rinaldi Carneiro, Rubens Antônio |
dc.subject.por.fl_str_mv |
Abdominal effusion Dog Eosinophils. Cão Efusão abdominal Eosinófilos. |
topic |
Abdominal effusion Dog Eosinophils. Cão Efusão abdominal Eosinófilos. |
description |
Eosinophils are cells of the immune system that have several important functions including phagocytosis of microorganisms, antigen presentation, contribution to chronic inflammation, and immunity against parasites. The hypereosinophilic syndrome (HES) is a rare disease in humans that is characterized by persistent eosinophilia (over six months) and variable eosinophil infiltration in organs such as the lungs, spleen, liver, lymph nodes, bone marrow, and gastrointestinal tract. Once in the tissues, these cells can cause damage by various mechanisms such as release of cytotoxic oxygen free radical and proteins. No etiology has yet been established for HES. The clinical signs vary and relate to the organs involved. In veterinary medicine, the disease has been described in cats, but rarely in dogs, with Rottweilers apparently more predisposed to developing the disease. Owing to the small number of cases reported in the veterinary literature, the prognosis of this disease and the most appropriate treatment options are unclear. Although it can be fatal in animals showing severe clinical symptoms, spontaneous remission may also occur. This study reports a case of HES in a Rottweiler in which the predominant clinical sign was abdominal effusion. We discuss the clinical and laboratory aspects of the disease. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259 10.5433/1679-0359.2017v38n1p311 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259 |
identifier_str_mv |
10.5433/1679-0359.2017v38n1p311 |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259/20611 https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259/35637 https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259/35638 https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259/35639 https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259/35640 https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/21259/38826 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf image/jpeg image/jpeg image/jpeg application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 38 No. 1 (2017); 311-316 Semina: Ciências Agrárias; v. 38 n. 1 (2017); 311-316 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
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1750315421997727744 |