Accumulative copper poisoning in buffaloes

Detalhes bibliográficos
Autor(a) principal: Minervino, Antonio Humberto Hamad
Data de Publicação: 2009
Outros Autores: Barrêto Júnior, Raimundo Alves, Ferreira, Rodrigo Nogueira Fernandes, Saut, João Paulo Elsen, Meira Júnior, Enoch Brandão de Sousa, Rodrigues, Frederico Augusto Mazzocca Lopes, Nakagawa, Tizianne Larissa Duim Ribeiro, Headley, Selwyn Arlington, Ortolani, Enrico Lippi
Tipo de documento: Artigo
Idioma: por
Título da fonte: Semina. Ciências Agrárias (Online)
Texto Completo: https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2596
Resumo: The main objective of this study was to evaluate the clinical and hematological alterations, and the hepatic concentration of Cu in buffaloes with chronic copper poisoning (CCP). Ten buffalo yearling steers were randomly distributed into two groups: one copper supplemented (BUFCu; n = 6) and another control group (BUF; n = 4). The group BUFCu received, by ruminal fistula, 2 mg Cu/kgBW (as CuSO4.5H2O) daily during one week; after which 2 mg Cu/kgBW was added during each additional week, until the end of the experiment (105th day). Three liver biopsies were realized during the experiment (day zero, 45th, and 105th day) to determine the degree of copper accumulation. Alterations in body weight, clinical examination, and hematological values were monitored every 15 days. Two buffaloes supplemented with copper demonstrated clinical manifestations consistent with CCP, and died. Two distinct clinical manifestations were observed, one classical (n = 1) and another atypical (n = 1), characterized by remarkable high levels of liver copper, progressive hyporexia followed by anorexia, dehydration, severe apathy, decreased rumen movements, oliguria, and death. Some animals were resistant to CCP although high copper intake. In buffalos with clinical picture similar to the one described as atypical, CCP should be considered as a possible diagnostic even without presence of macroscopic hemoglobinuria.
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spelling Accumulative copper poisoning in buffaloesIntoxicação cúprica acumulativa em búfalosCopperClinical manifestations. liverBuffaloes.CobreSintomasFígadoBúfalo.The main objective of this study was to evaluate the clinical and hematological alterations, and the hepatic concentration of Cu in buffaloes with chronic copper poisoning (CCP). Ten buffalo yearling steers were randomly distributed into two groups: one copper supplemented (BUFCu; n = 6) and another control group (BUF; n = 4). The group BUFCu received, by ruminal fistula, 2 mg Cu/kgBW (as CuSO4.5H2O) daily during one week; after which 2 mg Cu/kgBW was added during each additional week, until the end of the experiment (105th day). Three liver biopsies were realized during the experiment (day zero, 45th, and 105th day) to determine the degree of copper accumulation. Alterations in body weight, clinical examination, and hematological values were monitored every 15 days. Two buffaloes supplemented with copper demonstrated clinical manifestations consistent with CCP, and died. Two distinct clinical manifestations were observed, one classical (n = 1) and another atypical (n = 1), characterized by remarkable high levels of liver copper, progressive hyporexia followed by anorexia, dehydration, severe apathy, decreased rumen movements, oliguria, and death. Some animals were resistant to CCP although high copper intake. In buffalos with clinical picture similar to the one described as atypical, CCP should be considered as a possible diagnostic even without presence of macroscopic hemoglobinuria.O presente trabalho objetivou analisar o quadro clínico, variáveis metabólicas e a concentração de cobre nos tecidos de bufalinos submetidos à intoxicação cúprica acumulativa (ICA). Foram utilizados 10 bufalinos jovens, da raça Murrah, aleatoriamente distribuídos em seis animais no grupo suplementado com cobre (BUFCu) e quatro no grupo controle (BUF). O grupo BUFCu recebeu suplementação progressiva de cobre através de administração diária de solução aquosa deste microelemento, por meio da fistula ruminal. A dose diária inicial era de 2 mg de Cu/kgPV (CuSO4.5H2O), durante 7 dias, sendo esta dose de cobre aumentada em 2 mg/kgPV a cada semana, até o término do experimento (105 dias). Foram realizadas três biópsias hepáticas (dias 0 – 45 – 105) nos animais para determinação da concentração de Cu e de Zn. Quinzenalmente, foi realizado exame clínico, pesagem e coleta de sangue. Dois búfalos do grupo BUFCu manifestaram quadro clínico fatal sugestivo de ICA. Destaca-se a presença de dois quadros clínicos diferentes, o clássico (n = 1) e um atípico (n = 1), caracterizado pelo acúmulo destacado de cobre hepático, hiporexia progressiva seguida de anorexia, desidratação, oligúria, apatia acentuada e morte, mas sem apresentar hemoglobinúria. Quatro búfalos foram resistentes à ICA a despeito da administração de altas quantidades de cobre. Em búfalos que apresentem quadros clínicos similares ao quadro descrito como atípico, a ICA pode ser considerada como um possível diagnóstico mesmo sem a observação macroscópica de hemoglobinúria.UEL2009-07-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/259610.5433/1679-0359.2009v30n2p407Semina: Ciências Agrárias; Vol. 30 No. 2 (2009); 407-416Semina: Ciências Agrárias; v. 30 n. 2 (2009); 407-4161679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELporhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2596/2253Minervino, Antonio Humberto HamadBarrêto Júnior, Raimundo AlvesFerreira, Rodrigo Nogueira FernandesSaut, João Paulo ElsenMeira Júnior, Enoch Brandão de SousaRodrigues, Frederico Augusto Mazzocca LopesNakagawa, Tizianne Larissa Duim RibeiroHeadley, Selwyn ArlingtonOrtolani, Enrico Lippiinfo:eu-repo/semantics/openAccess2015-11-19T18:38:36Zoai:ojs.pkp.sfu.ca:article/2596Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2015-11-19T18:38:36Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false
dc.title.none.fl_str_mv Accumulative copper poisoning in buffaloes
Intoxicação cúprica acumulativa em búfalos
title Accumulative copper poisoning in buffaloes
spellingShingle Accumulative copper poisoning in buffaloes
Minervino, Antonio Humberto Hamad
Copper
Clinical manifestations. liver
Buffaloes.
Cobre
Sintomas
Fígado
Búfalo.
title_short Accumulative copper poisoning in buffaloes
title_full Accumulative copper poisoning in buffaloes
title_fullStr Accumulative copper poisoning in buffaloes
title_full_unstemmed Accumulative copper poisoning in buffaloes
title_sort Accumulative copper poisoning in buffaloes
author Minervino, Antonio Humberto Hamad
author_facet Minervino, Antonio Humberto Hamad
Barrêto Júnior, Raimundo Alves
Ferreira, Rodrigo Nogueira Fernandes
Saut, João Paulo Elsen
Meira Júnior, Enoch Brandão de Sousa
Rodrigues, Frederico Augusto Mazzocca Lopes
Nakagawa, Tizianne Larissa Duim Ribeiro
Headley, Selwyn Arlington
Ortolani, Enrico Lippi
author_role author
author2 Barrêto Júnior, Raimundo Alves
Ferreira, Rodrigo Nogueira Fernandes
Saut, João Paulo Elsen
Meira Júnior, Enoch Brandão de Sousa
Rodrigues, Frederico Augusto Mazzocca Lopes
Nakagawa, Tizianne Larissa Duim Ribeiro
Headley, Selwyn Arlington
Ortolani, Enrico Lippi
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Minervino, Antonio Humberto Hamad
Barrêto Júnior, Raimundo Alves
Ferreira, Rodrigo Nogueira Fernandes
Saut, João Paulo Elsen
Meira Júnior, Enoch Brandão de Sousa
Rodrigues, Frederico Augusto Mazzocca Lopes
Nakagawa, Tizianne Larissa Duim Ribeiro
Headley, Selwyn Arlington
Ortolani, Enrico Lippi
dc.subject.por.fl_str_mv Copper
Clinical manifestations. liver
Buffaloes.
Cobre
Sintomas
Fígado
Búfalo.
topic Copper
Clinical manifestations. liver
Buffaloes.
Cobre
Sintomas
Fígado
Búfalo.
description The main objective of this study was to evaluate the clinical and hematological alterations, and the hepatic concentration of Cu in buffaloes with chronic copper poisoning (CCP). Ten buffalo yearling steers were randomly distributed into two groups: one copper supplemented (BUFCu; n = 6) and another control group (BUF; n = 4). The group BUFCu received, by ruminal fistula, 2 mg Cu/kgBW (as CuSO4.5H2O) daily during one week; after which 2 mg Cu/kgBW was added during each additional week, until the end of the experiment (105th day). Three liver biopsies were realized during the experiment (day zero, 45th, and 105th day) to determine the degree of copper accumulation. Alterations in body weight, clinical examination, and hematological values were monitored every 15 days. Two buffaloes supplemented with copper demonstrated clinical manifestations consistent with CCP, and died. Two distinct clinical manifestations were observed, one classical (n = 1) and another atypical (n = 1), characterized by remarkable high levels of liver copper, progressive hyporexia followed by anorexia, dehydration, severe apathy, decreased rumen movements, oliguria, and death. Some animals were resistant to CCP although high copper intake. In buffalos with clinical picture similar to the one described as atypical, CCP should be considered as a possible diagnostic even without presence of macroscopic hemoglobinuria.
publishDate 2009
dc.date.none.fl_str_mv 2009-07-21
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2596
10.5433/1679-0359.2009v30n2p407
url https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2596
identifier_str_mv 10.5433/1679-0359.2009v30n2p407
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2596/2253
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UEL
publisher.none.fl_str_mv UEL
dc.source.none.fl_str_mv Semina: Ciências Agrárias; Vol. 30 No. 2 (2009); 407-416
Semina: Ciências Agrárias; v. 30 n. 2 (2009); 407-416
1679-0359
1676-546X
reponame:Semina. Ciências Agrárias (Online)
instname:Universidade Estadual de Londrina (UEL)
instacron:UEL
instname_str Universidade Estadual de Londrina (UEL)
instacron_str UEL
institution UEL
reponame_str Semina. Ciências Agrárias (Online)
collection Semina. Ciências Agrárias (Online)
repository.name.fl_str_mv Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)
repository.mail.fl_str_mv semina.agrarias@uel.br
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