Efficacy of drugs against Giardia muris in mice Mus musculus naturally infected

Detalhes bibliográficos
Autor(a) principal: Silva, Aleksandro Schafer da
Data de Publicação: 2008
Outros Autores: Silva, Marcos Kipper da, Oliveira, Camila Belmonte, Zanette, Régis Adriel, Monteiro, Silvia Gonzalez
Tipo de documento: Artigo
Idioma: por
Título da fonte: Semina. Ciências Agrárias (Online)
Texto Completo: https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2877
Resumo: This study aimed to evaluate the efficacy of metronidazole, fenbendazole and secnidazole against Giardia muris in mice naturally infected. Forty mice of the species Mus musculus were divided in four groups of ten each, being group A non treated, the control group and groups B, C and D treated with 4mg/ml of metronidazole, fenbendazole and secnidazole, respectively. Two feces collection, on day 0 and on day 10 after treatment, were done in order to evaluate the efficacy of the drugs. Samples were analyzed by the centrifugal-flotation method with zinc sulfate. Efficacy of 97,05% for metronidazole, 98,30% for fenbendazole and 100% for secnidazole were observed in the study. According to the results it was concluded that the tested drugs were effective for the treatment of mice parasitized by Giardia muris.
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spelling Efficacy of drugs against Giardia muris in mice Mus musculus naturally infectedEficácia de drogas contra Giardia muris em camundongos Mus musculus naturalmente infectadosMetronidazoleFenbendazoleSecnidazoleProtozoanRodents.MetronidazolFenbendazoleSecnidazolProtozoárioRoedores.This study aimed to evaluate the efficacy of metronidazole, fenbendazole and secnidazole against Giardia muris in mice naturally infected. Forty mice of the species Mus musculus were divided in four groups of ten each, being group A non treated, the control group and groups B, C and D treated with 4mg/ml of metronidazole, fenbendazole and secnidazole, respectively. Two feces collection, on day 0 and on day 10 after treatment, were done in order to evaluate the efficacy of the drugs. Samples were analyzed by the centrifugal-flotation method with zinc sulfate. Efficacy of 97,05% for metronidazole, 98,30% for fenbendazole and 100% for secnidazole were observed in the study. According to the results it was concluded that the tested drugs were effective for the treatment of mice parasitized by Giardia muris.Este estudo visou avaliar a eficácia do metronidazol, fenbendazole e secnidazol contra Giardia muris em camundongos naturalmente infectados. Foram utilizados 40 camundongos da espécie Mus musculus divididos em quatro grupos de 10 animais cada, sendo grupo A, grupo controle, não tratados, e grupos B, C e D tratados com 4mg/ml de metronidazol, fenbendazole e secnidazol, respectivamente. Para avaliar a eficácia dos medicamentos foram realizadas duas coletas de fezes uma no dia zero e outra 10 dias após tratamento. As amostras foram processadas e analisadas a partir do método de centrífugo-flutuação com sulfato de zinco. No estudo observou-se eficácia de 97,05% para metronidazol, 98,30% para fenbendazole e 100% para secnidazol no tratamento de giardiase murina. Com base nos resultados concluí-se que as drogas testadas apresentaram eficácia no tratamento de camundongos parasitados por Giardia muris.UEL2008-08-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por paresapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/287710.5433/1679-0359.2008v29n1p175Semina: Ciências Agrárias; Vol. 29 No. 1 (2008); 175-178Semina: Ciências Agrárias; v. 29 n. 1 (2008); 175-1781679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELporhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2877/2438Silva, Aleksandro Schafer daSilva, Marcos Kipper daOliveira, Camila BelmonteZanette, Régis AdrielMonteiro, Silvia Gonzalezinfo:eu-repo/semantics/openAccess2015-11-19T18:38:52Zoai:ojs.pkp.sfu.ca:article/2877Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2015-11-19T18:38:52Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false
dc.title.none.fl_str_mv Efficacy of drugs against Giardia muris in mice Mus musculus naturally infected
Eficácia de drogas contra Giardia muris em camundongos Mus musculus naturalmente infectados
title Efficacy of drugs against Giardia muris in mice Mus musculus naturally infected
spellingShingle Efficacy of drugs against Giardia muris in mice Mus musculus naturally infected
Silva, Aleksandro Schafer da
Metronidazole
Fenbendazole
Secnidazole
Protozoan
Rodents.
Metronidazol
Fenbendazole
Secnidazol
Protozoário
Roedores.
title_short Efficacy of drugs against Giardia muris in mice Mus musculus naturally infected
title_full Efficacy of drugs against Giardia muris in mice Mus musculus naturally infected
title_fullStr Efficacy of drugs against Giardia muris in mice Mus musculus naturally infected
title_full_unstemmed Efficacy of drugs against Giardia muris in mice Mus musculus naturally infected
title_sort Efficacy of drugs against Giardia muris in mice Mus musculus naturally infected
author Silva, Aleksandro Schafer da
author_facet Silva, Aleksandro Schafer da
Silva, Marcos Kipper da
Oliveira, Camila Belmonte
Zanette, Régis Adriel
Monteiro, Silvia Gonzalez
author_role author
author2 Silva, Marcos Kipper da
Oliveira, Camila Belmonte
Zanette, Régis Adriel
Monteiro, Silvia Gonzalez
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva, Aleksandro Schafer da
Silva, Marcos Kipper da
Oliveira, Camila Belmonte
Zanette, Régis Adriel
Monteiro, Silvia Gonzalez
dc.subject.por.fl_str_mv Metronidazole
Fenbendazole
Secnidazole
Protozoan
Rodents.
Metronidazol
Fenbendazole
Secnidazol
Protozoário
Roedores.
topic Metronidazole
Fenbendazole
Secnidazole
Protozoan
Rodents.
Metronidazol
Fenbendazole
Secnidazol
Protozoário
Roedores.
description This study aimed to evaluate the efficacy of metronidazole, fenbendazole and secnidazole against Giardia muris in mice naturally infected. Forty mice of the species Mus musculus were divided in four groups of ten each, being group A non treated, the control group and groups B, C and D treated with 4mg/ml of metronidazole, fenbendazole and secnidazole, respectively. Two feces collection, on day 0 and on day 10 after treatment, were done in order to evaluate the efficacy of the drugs. Samples were analyzed by the centrifugal-flotation method with zinc sulfate. Efficacy of 97,05% for metronidazole, 98,30% for fenbendazole and 100% for secnidazole were observed in the study. According to the results it was concluded that the tested drugs were effective for the treatment of mice parasitized by Giardia muris.
publishDate 2008
dc.date.none.fl_str_mv 2008-08-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado por pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2877
10.5433/1679-0359.2008v29n1p175
url https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2877
identifier_str_mv 10.5433/1679-0359.2008v29n1p175
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2877/2438
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UEL
publisher.none.fl_str_mv UEL
dc.source.none.fl_str_mv Semina: Ciências Agrárias; Vol. 29 No. 1 (2008); 175-178
Semina: Ciências Agrárias; v. 29 n. 1 (2008); 175-178
1679-0359
1676-546X
reponame:Semina. Ciências Agrárias (Online)
instname:Universidade Estadual de Londrina (UEL)
instacron:UEL
instname_str Universidade Estadual de Londrina (UEL)
instacron_str UEL
institution UEL
reponame_str Semina. Ciências Agrárias (Online)
collection Semina. Ciências Agrárias (Online)
repository.name.fl_str_mv Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)
repository.mail.fl_str_mv semina.agrarias@uel.br
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