Post-natal development of rats` offspring treated with the ethanol extract of Neem leaves (Azadirachta indica A. Juss) during pregnancy and lactation
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Scientiarum Biological Sciences |
Texto Completo: | http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/24976 |
Resumo: | Teratogenicity and developmental abnormalities in the offspring of female rats that ingested ethanol extract of Neem plants during pregnancy and lactation period were assessed. Twenty-four female Wistar rats were randomly distributed in control group and in three experimental groups and treated during the 4th, 5th, and 6th day of pregnancy. After birth, the lactating females received, by gavage, 65, 135 and 200 mg kg-1 of Neem ethanol extract, during 15 days. Results show, there was no significant difference in body mass index of neonatal rats in the 4 groups evaluated, whereas mean rate of offspring survival was 79.4%. Hair growth, incisor teeth eruption, ear detachment, eyelid opening, and spontaneous ambulation were similar for all groups. Likewise, physical development and development of motor activity, ambulation, and postural reflexes were similar for all groups. The administration of Neem ethanol extract did not cause any reproductive or systemic toxicity in animals. Results show that, Neem ethanol extract safe at doses 65, 135 and 200 mg kg-1 in pregnant or lactating rats. |
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Post-natal development of rats` offspring treated with the ethanol extract of Neem leaves (Azadirachta indica A. Juss) during pregnancy and lactationmedicinal plantreproductionteratogenicityphysical developmentrodentsMorfologia animal e ToxicologiaTeratogenicity and developmental abnormalities in the offspring of female rats that ingested ethanol extract of Neem plants during pregnancy and lactation period were assessed. Twenty-four female Wistar rats were randomly distributed in control group and in three experimental groups and treated during the 4th, 5th, and 6th day of pregnancy. After birth, the lactating females received, by gavage, 65, 135 and 200 mg kg-1 of Neem ethanol extract, during 15 days. Results show, there was no significant difference in body mass index of neonatal rats in the 4 groups evaluated, whereas mean rate of offspring survival was 79.4%. Hair growth, incisor teeth eruption, ear detachment, eyelid opening, and spontaneous ambulation were similar for all groups. Likewise, physical development and development of motor activity, ambulation, and postural reflexes were similar for all groups. The administration of Neem ethanol extract did not cause any reproductive or systemic toxicity in animals. Results show that, Neem ethanol extract safe at doses 65, 135 and 200 mg kg-1 in pregnant or lactating rats. Universidade Estadual De Maringá2015-08-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfapplication/mswordapplication/ziphttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/2497610.4025/actascibiolsci.v37i2.24976Acta Scientiarum. Biological Sciences; Vol 37 No 2 (2015); 219-224Acta Scientiarum. Biological Sciences; v. 37 n. 2 (2015); 219-2241807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMenghttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/24976/pdf_58http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/24976/751375143749http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/24976/751375143750http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/24976/751375143751Silva, Vanessa Carla Lima daSilva, Francine Maria de FrançaMeunier, Isabelle Maria JacquelineSilva, Tânia Maria Sarmento daSilva Júnior, Valdemiro Amaro daMaia, Frederico Celso Lyrainfo:eu-repo/semantics/openAccess2015-08-06T15:38:50Zoai:periodicos.uem.br/ojs:article/24976Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2015-08-06T15:38:50Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
Post-natal development of rats` offspring treated with the ethanol extract of Neem leaves (Azadirachta indica A. Juss) during pregnancy and lactation |
title |
Post-natal development of rats` offspring treated with the ethanol extract of Neem leaves (Azadirachta indica A. Juss) during pregnancy and lactation |
spellingShingle |
Post-natal development of rats` offspring treated with the ethanol extract of Neem leaves (Azadirachta indica A. Juss) during pregnancy and lactation Silva, Vanessa Carla Lima da medicinal plant reproduction teratogenicity physical development rodents Morfologia animal e Toxicologia |
title_short |
Post-natal development of rats` offspring treated with the ethanol extract of Neem leaves (Azadirachta indica A. Juss) during pregnancy and lactation |
title_full |
Post-natal development of rats` offspring treated with the ethanol extract of Neem leaves (Azadirachta indica A. Juss) during pregnancy and lactation |
title_fullStr |
Post-natal development of rats` offspring treated with the ethanol extract of Neem leaves (Azadirachta indica A. Juss) during pregnancy and lactation |
title_full_unstemmed |
Post-natal development of rats` offspring treated with the ethanol extract of Neem leaves (Azadirachta indica A. Juss) during pregnancy and lactation |
title_sort |
Post-natal development of rats` offspring treated with the ethanol extract of Neem leaves (Azadirachta indica A. Juss) during pregnancy and lactation |
author |
Silva, Vanessa Carla Lima da |
author_facet |
Silva, Vanessa Carla Lima da Silva, Francine Maria de França Meunier, Isabelle Maria Jacqueline Silva, Tânia Maria Sarmento da Silva Júnior, Valdemiro Amaro da Maia, Frederico Celso Lyra |
author_role |
author |
author2 |
Silva, Francine Maria de França Meunier, Isabelle Maria Jacqueline Silva, Tânia Maria Sarmento da Silva Júnior, Valdemiro Amaro da Maia, Frederico Celso Lyra |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Vanessa Carla Lima da Silva, Francine Maria de França Meunier, Isabelle Maria Jacqueline Silva, Tânia Maria Sarmento da Silva Júnior, Valdemiro Amaro da Maia, Frederico Celso Lyra |
dc.subject.por.fl_str_mv |
medicinal plant reproduction teratogenicity physical development rodents Morfologia animal e Toxicologia |
topic |
medicinal plant reproduction teratogenicity physical development rodents Morfologia animal e Toxicologia |
description |
Teratogenicity and developmental abnormalities in the offspring of female rats that ingested ethanol extract of Neem plants during pregnancy and lactation period were assessed. Twenty-four female Wistar rats were randomly distributed in control group and in three experimental groups and treated during the 4th, 5th, and 6th day of pregnancy. After birth, the lactating females received, by gavage, 65, 135 and 200 mg kg-1 of Neem ethanol extract, during 15 days. Results show, there was no significant difference in body mass index of neonatal rats in the 4 groups evaluated, whereas mean rate of offspring survival was 79.4%. Hair growth, incisor teeth eruption, ear detachment, eyelid opening, and spontaneous ambulation were similar for all groups. Likewise, physical development and development of motor activity, ambulation, and postural reflexes were similar for all groups. The administration of Neem ethanol extract did not cause any reproductive or systemic toxicity in animals. Results show that, Neem ethanol extract safe at doses 65, 135 and 200 mg kg-1 in pregnant or lactating rats. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-06 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/24976 10.4025/actascibiolsci.v37i2.24976 |
url |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/24976 |
identifier_str_mv |
10.4025/actascibiolsci.v37i2.24976 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/24976/pdf_58 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/24976/751375143749 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/24976/751375143750 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/24976/751375143751 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/msword application/zip |
dc.publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
dc.source.none.fl_str_mv |
Acta Scientiarum. Biological Sciences; Vol 37 No 2 (2015); 219-224 Acta Scientiarum. Biological Sciences; v. 37 n. 2 (2015); 219-224 1807-863X 1679-9283 reponame:Acta Scientiarum Biological Sciences instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
instname_str |
Universidade Estadual de Maringá (UEM) |
instacron_str |
UEM |
institution |
UEM |
reponame_str |
Acta Scientiarum Biological Sciences |
collection |
Acta Scientiarum Biological Sciences |
repository.name.fl_str_mv |
Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
||actabiol@uem.br |
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1799317396053295104 |