Curcumin protects remote organs against injury that is caused by intestinal ischemia and reperfusion
Main Author: | |
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Publication Date: | 2020 |
Other Authors: | , , |
Format: | Article |
Language: | eng |
Source: | Acta Scientiarum Biological Sciences |
Download full: | http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/50588 |
Summary: | In addition to several local pathophysiological consequences, intestinal injury that is caused by ischemia and reperfusion can result in the development of lesions in remote organs. Curcumin has therapeutic potential because of its antiinflammatory and antioxidant effects. The present study evaluated the effects of curcumin on oxidative and inflammatory parameters in the liver and kidneys in rats that were subjected to intestinal ischemia and reperfusion. The rats were subjected to 45 min. of ischemia followed by 7 days of reperfusion and treated daily with 60 mg kg-1 curcumin. The liver and kidneys were collected, weighed, and biochemically analyzed. Intestinal ischemia and reperfusion increased levels of lipid hydroperoxide (LOOH), decreased levels of reduced glutathione (GSH), and increased the enzymatic activity of superoxide dismutase (SOD), glutathione S-transferase (GST), and myeloperoxidase (MPO) in the liver. Intestinal ischemia and reperfusion decreased kidney weight and increased GST activity in the kidneys. Curcumin prevented these changes in the liver and kidneys. Intestinal ischemia and reperfusion mainly affected the liver, promoting inflammation and oxidative stress. The kidneys underwent repair much earlier than the liver, in which they did not present alterations of MPO or main parameters of oxidative stress after 7 days of reperfusion. Treatment with curcumin had beneficial effects, ameliorating or even preventing injury that was caused by intestinal ischemia and reperfusion in the liver and kidneys in rats |
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Curcumin protects remote organs against injury that is caused by intestinal ischemia and reperfusion Curcumin protects remote organs against injury that is caused by intestinal ischemia and reperfusion oxidative stress; myeloperoxidase; antioxidant; liver; kidneys.oxidative stress; myeloperoxidase; antioxidant; liver; kidneys In addition to several local pathophysiological consequences, intestinal injury that is caused by ischemia and reperfusion can result in the development of lesions in remote organs. Curcumin has therapeutic potential because of its antiinflammatory and antioxidant effects. The present study evaluated the effects of curcumin on oxidative and inflammatory parameters in the liver and kidneys in rats that were subjected to intestinal ischemia and reperfusion. The rats were subjected to 45 min. of ischemia followed by 7 days of reperfusion and treated daily with 60 mg kg-1 curcumin. The liver and kidneys were collected, weighed, and biochemically analyzed. Intestinal ischemia and reperfusion increased levels of lipid hydroperoxide (LOOH), decreased levels of reduced glutathione (GSH), and increased the enzymatic activity of superoxide dismutase (SOD), glutathione S-transferase (GST), and myeloperoxidase (MPO) in the liver. Intestinal ischemia and reperfusion decreased kidney weight and increased GST activity in the kidneys. Curcumin prevented these changes in the liver and kidneys. Intestinal ischemia and reperfusion mainly affected the liver, promoting inflammation and oxidative stress. The kidneys underwent repair much earlier than the liver, in which they did not present alterations of MPO or main parameters of oxidative stress after 7 days of reperfusion. Treatment with curcumin had beneficial effects, ameliorating or even preventing injury that was caused by intestinal ischemia and reperfusion in the liver and kidneys in rats In addition to several local pathophysiological consequences, intestinal injury that is caused by ischemia and reperfusion can result in the development of lesions in remote organs. Curcumin has therapeutic potential because of its antiinflammatory and antioxidant effects. The present study evaluated the effects of curcumin on oxidative and inflammatory parameters in the liver and kidneys in rats that were subjected to intestinal ischemia and reperfusion. The rats were subjected to 45 min. of ischemia followed by 7 days of reperfusion and treated daily with 60 mg kg-1 curcumin. The liver and kidneys were collected, weighed, and biochemically analyzed. Intestinal ischemia and reperfusion increased levels of lipid hydroperoxide (LOOH), decreased levels of reduced glutathione (GSH), and increased the enzymatic activity of superoxide dismutase (SOD), glutathione S-transferase (GST), and myeloperoxidase (MPO) in the liver. Intestinal ischemia and reperfusion decreased kidney weight and increased GST activity in the kidneys. Curcumin prevented these changes in the liver and kidneys. Intestinal ischemia and reperfusion mainly affected the liver, promoting inflammation and oxidative stress. The kidneys underwent repair much earlier than the liver, in which they did not present alterations of MPO or main parameters of oxidative stress after 7 days of reperfusion. Treatment with curcumin had beneficial effects, ameliorating or even preventing injury that was caused by intestinal ischemia and reperfusion in the liver and kidneys in ratsUniversidade Estadual De Maringá2020-05-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/5058810.4025/actascibiolsci.v42i1.50588Acta Scientiarum. Biological Sciences; Vol 42 (2020): Publicação contínua; e50588Acta Scientiarum. Biological Sciences; v. 42 (2020): Publicação contínua; e505881807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMenghttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/50588/751375150064Copyright (c) 2020 Acta Scientiarum. Biological Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBorges, Stephanie Carvalho Tironi, Lia Mara TeobaldoSilva, Luísa Mota da Buttow, Nilza Cristina 2020-11-16T16:25:44Zoai:periodicos.uem.br/ojs:article/50588Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2020-11-16T16:25:44Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
Curcumin protects remote organs against injury that is caused by intestinal ischemia and reperfusion Curcumin protects remote organs against injury that is caused by intestinal ischemia and reperfusion |
title |
Curcumin protects remote organs against injury that is caused by intestinal ischemia and reperfusion |
spellingShingle |
Curcumin protects remote organs against injury that is caused by intestinal ischemia and reperfusion Borges, Stephanie Carvalho oxidative stress; myeloperoxidase; antioxidant; liver; kidneys. oxidative stress; myeloperoxidase; antioxidant; liver; kidneys |
title_short |
Curcumin protects remote organs against injury that is caused by intestinal ischemia and reperfusion |
title_full |
Curcumin protects remote organs against injury that is caused by intestinal ischemia and reperfusion |
title_fullStr |
Curcumin protects remote organs against injury that is caused by intestinal ischemia and reperfusion |
title_full_unstemmed |
Curcumin protects remote organs against injury that is caused by intestinal ischemia and reperfusion |
title_sort |
Curcumin protects remote organs against injury that is caused by intestinal ischemia and reperfusion |
author |
Borges, Stephanie Carvalho |
author_facet |
Borges, Stephanie Carvalho Tironi, Lia Mara Teobaldo Silva, Luísa Mota da Buttow, Nilza Cristina |
author_role |
author |
author2 |
Tironi, Lia Mara Teobaldo Silva, Luísa Mota da Buttow, Nilza Cristina |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Borges, Stephanie Carvalho Tironi, Lia Mara Teobaldo Silva, Luísa Mota da Buttow, Nilza Cristina |
dc.subject.por.fl_str_mv |
oxidative stress; myeloperoxidase; antioxidant; liver; kidneys. oxidative stress; myeloperoxidase; antioxidant; liver; kidneys |
topic |
oxidative stress; myeloperoxidase; antioxidant; liver; kidneys. oxidative stress; myeloperoxidase; antioxidant; liver; kidneys |
description |
In addition to several local pathophysiological consequences, intestinal injury that is caused by ischemia and reperfusion can result in the development of lesions in remote organs. Curcumin has therapeutic potential because of its antiinflammatory and antioxidant effects. The present study evaluated the effects of curcumin on oxidative and inflammatory parameters in the liver and kidneys in rats that were subjected to intestinal ischemia and reperfusion. The rats were subjected to 45 min. of ischemia followed by 7 days of reperfusion and treated daily with 60 mg kg-1 curcumin. The liver and kidneys were collected, weighed, and biochemically analyzed. Intestinal ischemia and reperfusion increased levels of lipid hydroperoxide (LOOH), decreased levels of reduced glutathione (GSH), and increased the enzymatic activity of superoxide dismutase (SOD), glutathione S-transferase (GST), and myeloperoxidase (MPO) in the liver. Intestinal ischemia and reperfusion decreased kidney weight and increased GST activity in the kidneys. Curcumin prevented these changes in the liver and kidneys. Intestinal ischemia and reperfusion mainly affected the liver, promoting inflammation and oxidative stress. The kidneys underwent repair much earlier than the liver, in which they did not present alterations of MPO or main parameters of oxidative stress after 7 days of reperfusion. Treatment with curcumin had beneficial effects, ameliorating or even preventing injury that was caused by intestinal ischemia and reperfusion in the liver and kidneys in rats |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-05-19 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/50588 10.4025/actascibiolsci.v42i1.50588 |
url |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/50588 |
identifier_str_mv |
10.4025/actascibiolsci.v42i1.50588 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/50588/751375150064 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Acta Scientiarum. Biological Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Acta Scientiarum. Biological Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
dc.source.none.fl_str_mv |
Acta Scientiarum. Biological Sciences; Vol 42 (2020): Publicação contínua; e50588 Acta Scientiarum. Biological Sciences; v. 42 (2020): Publicação contínua; e50588 1807-863X 1679-9283 reponame:Acta Scientiarum Biological Sciences instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
instname_str |
Universidade Estadual de Maringá (UEM) |
instacron_str |
UEM |
institution |
UEM |
reponame_str |
Acta Scientiarum Biological Sciences |
collection |
Acta Scientiarum Biological Sciences |
repository.name.fl_str_mv |
Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
||actabiol@uem.br |
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1799317397547515904 |