NO- induced neuromuscular facilitation in the phrenic nerve diaphragm preparation of rats is Ca++ dependent - DOI: 10.4025/actascibiolsci.v26i4.1528

Detalhes bibliográficos
Autor(a) principal: Borges, Heraldo Esheveria
Data de Publicação: 2008
Outros Autores: Prado, Wilson Alves do
Tipo de documento: Artigo
Idioma: por
Título da fonte: Acta Scientiarum Biological Sciences
Texto Completo: http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/1528
Resumo: The research was carried out to verify whether the neuromuscular effects induced by nitric oxide (NO) might depend on extracellular level of Ca++. The donor of NO, sodium nitroprusside (SNP), and the analogue of cGMP, 8-Br-cGMP, increased the muscular contraction amplitude (MCA) in preparations indirectly stimulated at 0.2 Hz, but did not produce any effect when the nutrient solution was exchanged by Krebs buffer low Ca++/ high Mg++. SNP and 8-Br-cGMP reduced the MCA in preparations directly stimulated. Such effect was not recorded in Krebs buffer low Ca++/ high Mg++. Data suggest that the neuromuscular effects induced by NO or cGMP depend on extracellular level of Ca++
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spelling NO- induced neuromuscular facilitation in the phrenic nerve diaphragm preparation of rats is Ca++ dependent - DOI: 10.4025/actascibiolsci.v26i4.1528O efeito facilitatório do óxido nítrico sobre a transmissão neuromuscular de preparações nervo frênico- diafragma isolado de ratos é Ca++ dependente - DOI: 10.4025/actascibiolsci.v26i4.1528cálcioóxido nítriconitroprussiato de sódio2.01.00.00-0 Biologia GeralThe research was carried out to verify whether the neuromuscular effects induced by nitric oxide (NO) might depend on extracellular level of Ca++. The donor of NO, sodium nitroprusside (SNP), and the analogue of cGMP, 8-Br-cGMP, increased the muscular contraction amplitude (MCA) in preparations indirectly stimulated at 0.2 Hz, but did not produce any effect when the nutrient solution was exchanged by Krebs buffer low Ca++/ high Mg++. SNP and 8-Br-cGMP reduced the MCA in preparations directly stimulated. Such effect was not recorded in Krebs buffer low Ca++/ high Mg++. Data suggest that the neuromuscular effects induced by NO or cGMP depend on extracellular level of Ca++A pesquisa foi conduzida para verificar se os efeitos neuromusculares induzidos por óxido nítrico (NO) poderiam depender dos níveis extracelulares de Ca++. O doador de NO, nitroprussiato de sódio (NPS), e o análogo de GMPc, 8-Br-cGMP, aumentaram a amplitude das contrações musculares (ACM) em preparações indiretamente estimuladas a 0.2 Hz, mas não produziram efeitos quando a solução nutriente (Krebs normal) foi trocada por Krebs com baixo Ca++/ alto Mg++. NPS e 8-Br-cGMP reduziram a ACM quando as preparações foram diretamente estimuladas, mas tal efeito não foi observado com o uso de Krebs com baixo Ca++/ alto Mg++. Dados sugerem que os efeitos neuromusculares induzidos por NO dependem dos níveis extracelulares de Ca++Universidade Estadual De Maringá2008-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/152810.4025/actascibiolsci.v26i4.1528Acta Scientiarum. Biological Sciences; Vol 26 No 4 (2004); 471-473Acta Scientiarum. Biological Sciences; v. 26 n. 4 (2004); 471-4731807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMporhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/1528/956Borges, Heraldo EsheveriaPrado, Wilson Alves doinfo:eu-repo/semantics/openAccess2022-11-23T17:33:12Zoai:periodicos.uem.br/ojs:article/1528Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2022-11-23T17:33:12Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false
dc.title.none.fl_str_mv NO- induced neuromuscular facilitation in the phrenic nerve diaphragm preparation of rats is Ca++ dependent - DOI: 10.4025/actascibiolsci.v26i4.1528
O efeito facilitatório do óxido nítrico sobre a transmissão neuromuscular de preparações nervo frênico- diafragma isolado de ratos é Ca++ dependente - DOI: 10.4025/actascibiolsci.v26i4.1528
title NO- induced neuromuscular facilitation in the phrenic nerve diaphragm preparation of rats is Ca++ dependent - DOI: 10.4025/actascibiolsci.v26i4.1528
spellingShingle NO- induced neuromuscular facilitation in the phrenic nerve diaphragm preparation of rats is Ca++ dependent - DOI: 10.4025/actascibiolsci.v26i4.1528
Borges, Heraldo Esheveria
cálcio
óxido nítrico
nitroprussiato de sódio
2.01.00.00-0 Biologia Geral
title_short NO- induced neuromuscular facilitation in the phrenic nerve diaphragm preparation of rats is Ca++ dependent - DOI: 10.4025/actascibiolsci.v26i4.1528
title_full NO- induced neuromuscular facilitation in the phrenic nerve diaphragm preparation of rats is Ca++ dependent - DOI: 10.4025/actascibiolsci.v26i4.1528
title_fullStr NO- induced neuromuscular facilitation in the phrenic nerve diaphragm preparation of rats is Ca++ dependent - DOI: 10.4025/actascibiolsci.v26i4.1528
title_full_unstemmed NO- induced neuromuscular facilitation in the phrenic nerve diaphragm preparation of rats is Ca++ dependent - DOI: 10.4025/actascibiolsci.v26i4.1528
title_sort NO- induced neuromuscular facilitation in the phrenic nerve diaphragm preparation of rats is Ca++ dependent - DOI: 10.4025/actascibiolsci.v26i4.1528
author Borges, Heraldo Esheveria
author_facet Borges, Heraldo Esheveria
Prado, Wilson Alves do
author_role author
author2 Prado, Wilson Alves do
author2_role author
dc.contributor.author.fl_str_mv Borges, Heraldo Esheveria
Prado, Wilson Alves do
dc.subject.por.fl_str_mv cálcio
óxido nítrico
nitroprussiato de sódio
2.01.00.00-0 Biologia Geral
topic cálcio
óxido nítrico
nitroprussiato de sódio
2.01.00.00-0 Biologia Geral
description The research was carried out to verify whether the neuromuscular effects induced by nitric oxide (NO) might depend on extracellular level of Ca++. The donor of NO, sodium nitroprusside (SNP), and the analogue of cGMP, 8-Br-cGMP, increased the muscular contraction amplitude (MCA) in preparations indirectly stimulated at 0.2 Hz, but did not produce any effect when the nutrient solution was exchanged by Krebs buffer low Ca++/ high Mg++. SNP and 8-Br-cGMP reduced the MCA in preparations directly stimulated. Such effect was not recorded in Krebs buffer low Ca++/ high Mg++. Data suggest that the neuromuscular effects induced by NO or cGMP depend on extracellular level of Ca++
publishDate 2008
dc.date.none.fl_str_mv 2008-03-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/1528
10.4025/actascibiolsci.v26i4.1528
url http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/1528
identifier_str_mv 10.4025/actascibiolsci.v26i4.1528
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/1528/956
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual De Maringá
publisher.none.fl_str_mv Universidade Estadual De Maringá
dc.source.none.fl_str_mv Acta Scientiarum. Biological Sciences; Vol 26 No 4 (2004); 471-473
Acta Scientiarum. Biological Sciences; v. 26 n. 4 (2004); 471-473
1807-863X
1679-9283
reponame:Acta Scientiarum Biological Sciences
instname:Universidade Estadual de Maringá (UEM)
instacron:UEM
instname_str Universidade Estadual de Maringá (UEM)
instacron_str UEM
institution UEM
reponame_str Acta Scientiarum Biological Sciences
collection Acta Scientiarum Biological Sciences
repository.name.fl_str_mv Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)
repository.mail.fl_str_mv ||actabiol@uem.br
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