POTENTIAL THERAPIES FOR TREATMENT OF COVID-19
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng spa por |
Título da fonte: | Revista de Ciência Veterinária e Saúde Pública |
Texto Completo: | https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55502 |
Resumo: | Since discovery of the novel coronavirus (SARS-CoV-2) in December of 2019, this viral pneumonia originated in Wuhan, China quickly spread around the world. This new disease, called COVID-19 can cause Acute Respiratory Distress Syndrome (ARDS) due to an uncontrolled inflammatory response like sepsis, that leads to multiple organ failure and even death. Several pharmacotherapeutics alternatives are being tested over the world, looking for most diverse drugs that might be able to fight the infection. The objective of this paper is to review the main pharmacotherapeutics techniques development, as remdesivir, chloroquine/hydroxychloroquine, lopinavir plus ritonavir, interferon-β, ivermectin, anticoagulants, convalescent plasma and vaccine, currently undergoing clinical trials in order to evaluate its effectiveness and safety to combat the COVID-19, presenting their characteristics, possible adverse effects and main scientific findings of its potential action. In conclusion, some therapies presented promising in-vitro results or in the treatment of some patients, nonetheless, multicentric blinded placebo controlled clinical trials are necessary to determine their effectiveness, safety, dosage, and best time point of treatment. |
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Revista de Ciência Veterinária e Saúde Pública |
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POTENTIAL THERAPIES FOR TREATMENT OF COVID-19antiviralcoronavirusconvalescent plasmadrugsSARS-CoV-2Since discovery of the novel coronavirus (SARS-CoV-2) in December of 2019, this viral pneumonia originated in Wuhan, China quickly spread around the world. This new disease, called COVID-19 can cause Acute Respiratory Distress Syndrome (ARDS) due to an uncontrolled inflammatory response like sepsis, that leads to multiple organ failure and even death. Several pharmacotherapeutics alternatives are being tested over the world, looking for most diverse drugs that might be able to fight the infection. The objective of this paper is to review the main pharmacotherapeutics techniques development, as remdesivir, chloroquine/hydroxychloroquine, lopinavir plus ritonavir, interferon-β, ivermectin, anticoagulants, convalescent plasma and vaccine, currently undergoing clinical trials in order to evaluate its effectiveness and safety to combat the COVID-19, presenting their characteristics, possible adverse effects and main scientific findings of its potential action. In conclusion, some therapies presented promising in-vitro results or in the treatment of some patients, nonetheless, multicentric blinded placebo controlled clinical trials are necessary to determine their effectiveness, safety, dosage, and best time point of treatment.EDUEM - Universidade Estadual de Maringá2020-08-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTextoavaliado pelos paresapplication/pdfapplication/pdfapplication/pdfhttps://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/5550210.4025/revcivet.v7i1.55502Revista de Ciência Veterinária e Saúde Pública; v. 7 n. 1 (2020): V.7 N.1 2020; 062-0712358-4610reponame:Revista de Ciência Veterinária e Saúde Públicainstname:Universidade Estadual de Maringá (UEM)instacron:UEMengspaporhttps://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55502/751375150668https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55502/751375150669https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55502/751375150670Copyright (c) 2020 Revista de Ciência Veterinária e Saúde Públicainfo:eu-repo/semantics/openAccessGasser, BeatrizAndres Ramirez Uscategui, Ricardo2020-10-15T17:15:56Zoai:periodicos.uem.br/ojs:article/55502Revistahttps://periodicos.uem.br/ojs/index.php/RevCiVet/PUBhttps://periodicos.uem.br/ojs/index.php/RevCiVet/oaipaulomarcusso@gmail.com || periodicos@uem.br2358-46102358-4610opendoar:2020-10-15T17:15:56Revista de Ciência Veterinária e Saúde Pública - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
POTENTIAL THERAPIES FOR TREATMENT OF COVID-19 |
title |
POTENTIAL THERAPIES FOR TREATMENT OF COVID-19 |
spellingShingle |
POTENTIAL THERAPIES FOR TREATMENT OF COVID-19 Gasser, Beatriz antiviral coronavirus convalescent plasma drugs SARS-CoV-2 |
title_short |
POTENTIAL THERAPIES FOR TREATMENT OF COVID-19 |
title_full |
POTENTIAL THERAPIES FOR TREATMENT OF COVID-19 |
title_fullStr |
POTENTIAL THERAPIES FOR TREATMENT OF COVID-19 |
title_full_unstemmed |
POTENTIAL THERAPIES FOR TREATMENT OF COVID-19 |
title_sort |
POTENTIAL THERAPIES FOR TREATMENT OF COVID-19 |
author |
Gasser, Beatriz |
author_facet |
Gasser, Beatriz Andres Ramirez Uscategui, Ricardo |
author_role |
author |
author2 |
Andres Ramirez Uscategui, Ricardo |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Gasser, Beatriz Andres Ramirez Uscategui, Ricardo |
dc.subject.por.fl_str_mv |
antiviral coronavirus convalescent plasma drugs SARS-CoV-2 |
topic |
antiviral coronavirus convalescent plasma drugs SARS-CoV-2 |
description |
Since discovery of the novel coronavirus (SARS-CoV-2) in December of 2019, this viral pneumonia originated in Wuhan, China quickly spread around the world. This new disease, called COVID-19 can cause Acute Respiratory Distress Syndrome (ARDS) due to an uncontrolled inflammatory response like sepsis, that leads to multiple organ failure and even death. Several pharmacotherapeutics alternatives are being tested over the world, looking for most diverse drugs that might be able to fight the infection. The objective of this paper is to review the main pharmacotherapeutics techniques development, as remdesivir, chloroquine/hydroxychloroquine, lopinavir plus ritonavir, interferon-β, ivermectin, anticoagulants, convalescent plasma and vaccine, currently undergoing clinical trials in order to evaluate its effectiveness and safety to combat the COVID-19, presenting their characteristics, possible adverse effects and main scientific findings of its potential action. In conclusion, some therapies presented promising in-vitro results or in the treatment of some patients, nonetheless, multicentric blinded placebo controlled clinical trials are necessary to determine their effectiveness, safety, dosage, and best time point of treatment. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Texto avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55502 10.4025/revcivet.v7i1.55502 |
url |
https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55502 |
identifier_str_mv |
10.4025/revcivet.v7i1.55502 |
dc.language.iso.fl_str_mv |
eng spa por |
language |
eng spa por |
dc.relation.none.fl_str_mv |
https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55502/751375150668 https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55502/751375150669 https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55502/751375150670 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Revista de Ciência Veterinária e Saúde Pública info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Revista de Ciência Veterinária e Saúde Pública |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
EDUEM - Universidade Estadual de Maringá |
publisher.none.fl_str_mv |
EDUEM - Universidade Estadual de Maringá |
dc.source.none.fl_str_mv |
Revista de Ciência Veterinária e Saúde Pública; v. 7 n. 1 (2020): V.7 N.1 2020; 062-071 2358-4610 reponame:Revista de Ciência Veterinária e Saúde Pública instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
instname_str |
Universidade Estadual de Maringá (UEM) |
instacron_str |
UEM |
institution |
UEM |
reponame_str |
Revista de Ciência Veterinária e Saúde Pública |
collection |
Revista de Ciência Veterinária e Saúde Pública |
repository.name.fl_str_mv |
Revista de Ciência Veterinária e Saúde Pública - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
paulomarcusso@gmail.com || periodicos@uem.br |
_version_ |
1754650113787035648 |