Capacidade antioxidante e a prática de atividade física em indivíduos com lesão medular cervical

• Autor(a) principal: Borsatto, Juliana Esteves
• Data de Publicação: 2011
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/7259
• topic: Spinal cord injury, physical activity, fat, Alpha-Tocopherol; Lesão medular; Atividade física; Gordura; Alfa-Tocoferol; Lesões da medula espinhal - Dietoterapia; Exercícios físicos - Aspectos fisiológicos; Corpo - Composição; Ácidos graxos; CNPQ::CIENCIAS DA SAUDE::NUTRICAO

Spinal cord injury is associated with body composition and biochemical changes. In addition an increase of body fat and the accumulation in the trunk together the infectious process due to spinal injury can cause the increase in plasma concentration of C-reactive protein (CRP). Fat mass and the high concentration of CRP can stimulate the production of reactive oxygen species, favoring the oxidative imbalance and the onset of disease. It is possible that the practice of regular physical activity can act beneficially by contributing to a better body fat distribution and adaptation of antioxidant systems in these subjects. Considering the importance of this theme and few studies about this topic, the aim of this study was to compare body composition and biochemical markers of antioxidant status, in subjects with cervical spinal cord injury, physically active and not active. The study included 24tetraplegic male (32 ± 10 y and 10 ± 8 y of injury time), divided in two groups, physically active (n = 15, with practice of physical activity for at least 3 months, 3times / week or more, totaling a minimum period of 150 minutes / week) and non-active (n = 9). Body composition was determined by dual energy X-ray absorptiometry. Blood samples were collected after overnight fasting (12 hours) for determination of biochemical parameters: antioxidant capacity, uric acid, bilirubin, albumin, alpha-tocopherol, malondialdehyde and CRP in plasma, and activity of superoxide dismutase in erythrocytes. The active group showed no higher BMI (p =0.003), total fat (%) and trunk (%) (p = <0.001) than the physically active group. Relationship was found between CRP and percentagem of total fat (r=0,72,p=<0,001), trunk (r=0,70, p=<0,001), total fat mass (r=0,73, p=<0,001) and trunk(r=0,67, p=0,001).There was no significant difference between the biochemical indicators of antioxidant status, except by the concentration of CRP that was higherin the non-active group (p = 0.034). Considering the all subjects, 50% had deficiency of alpha-tocopherol (plasma concentration <11.6 mmol / L). Negative relationship was found between plasma alpha-tocopherol and CRP (r=-0.18, p=0.038). In theactive group was a positive relationship between the ratio time physical activity: time of injury and plasma malondialdehyde (r=0.38; p= 0.014). Our results, taken together, suggest that continued practice of physical activity after injury acts helping to better body composition and, possibly, a lower plasma concentration of CRP. The inadequate nutritional status in alpha-tocopherol can affect the antioxidant capacity, so actions are necessary to adjust the nutritional status of alpha-tocopherol for this group.