WNT-5A, but not matrix metalloproteinase 3 or b-catenin protein, expression is related to early stages of lip carcinogenesis

Detalhes bibliográficos
Autor(a) principal: Xavier, Flávia Caló de Aquino
Data de Publicação: 2009
Outros Autores: Rodini, Camila Oliveira, Ramalho, Luciana Maria Pedreira, Mantesso, Andrea, Nunes, Fabio Daumas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6272
Resumo: Trabalho completo: acesso restrito, p. 708–715
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spelling Xavier, Flávia Caló de AquinoRodini, Camila OliveiraRamalho, Luciana Maria PedreiraMantesso, AndreaNunes, Fabio DaumasXavier, Flávia Caló de AquinoRodini, Camila OliveiraRamalho, Luciana Maria PedreiraMantesso, AndreaNunes, Fabio Daumas2012-06-29T18:01:37Z20090904-2512http://www.repositorio.ufba.br/ri/handle/ri/6272v. 38, n. 9Trabalho completo: acesso restrito, p. 708–715Oncogenic Wnt/b-catenin signaling occurs in numerous types of cancers, but little is known about the role of the Wnt protein family member, WNT- 5A, in lip carcinogenesis. The aim of this study was to investigate WNT-5A, b-catenin, and matrix metalloproteinase (MMP)-3 protein expression in actinic cheilitis (AC), and lip squamous cell carcinoma (LSCC). METHODS: Twenty-one cases of AC, and fifty-one cases of LSCC were analyzed, with normal lip mucosa used as a control. Qualitative and semi-quantitative analyses of WNT-5A, b-catenin, and MMP-3 immunostaining pattern and cellular distribution were performed. RESULTS: WNT-5A was observed in more than 50% of the cells, scattered in all layers of AC, in contrast to the absence of immunostaining in normal lip mucosa. AC presented a higher level of WNT-5A expression than LSCC (P = 0.0289, Fisher test), while MMP-3 immunoexpression was statistically more significant in LSCC than in AC (P = 0.0285, Fisher test). Immunolabeling of b-catenin protein was differentially distributed between samples; the majority of AC cases (61.90%) demonstrated a membranous-cytoplasmic pattern, while a considerable number of LSCC cases (29.41%) revealed a cytoplasmic pattern, instead of the usual membranous pattern. CONCLUSIONS: The present results suggest that WNT-5A may be an important marker during initial events of AC malignant transformation, in which noncanonical and canonical Wnt/b-catenin signaling pathways could be involved. Additionally, WNT-5A might recruit other events in LSCC, such as MMP-3 protein synthesis, as its presence is increased in established malignant processes without b-catenin dependency.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-06-29T18:01:37Z No. of bitstreams: 1 (94)j.1600-0714.2009.00756.x.pdf: 727500 bytes, checksum: 404a9234c53b7fda5c2bb51357097019 (MD5)Made available in DSpace on 2012-06-29T18:01:37Z (GMT). No. of bitstreams: 1 (94)j.1600-0714.2009.00756.x.pdf: 727500 bytes, checksum: 404a9234c53b7fda5c2bb51357097019 (MD5) Previous issue date: 2009John Wiley and Sonshttp://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2009.00756.x/pdfreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAactinic cheilitisMMP-3squamous cell carcinomaWNT-5A proteinb-cateninWNT-5A, but not matrix metalloproteinase 3 or b-catenin protein, expression is related to early stages of lip carcinogenesisJournal of Oral Pathology and Medicineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL(94)j.1600-0714.2009.00756.x.pdf(94)j.1600-0714.2009.00756.x.pdfapplication/pdf727500https://repositorio.ufba.br/bitstream/ri/6272/1/%2894%29j.1600-0714.2009.00756.x.pdf404a9234c53b7fda5c2bb51357097019MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6272/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT(94)j.1600-0714.2009.00756.x.pdf.txt(94)j.1600-0714.2009.00756.x.pdf.txtExtracted texttext/plain34427https://repositorio.ufba.br/bitstream/ri/6272/3/%2894%29j.1600-0714.2009.00756.x.pdf.txt122a9d935300aec3949446c6fdec4d16MD53ri/62722022-07-05 14:03:21.317oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:21Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv WNT-5A, but not matrix metalloproteinase 3 or b-catenin protein, expression is related to early stages of lip carcinogenesis
dc.title.alternative.pt_BR.fl_str_mv Journal of Oral Pathology and Medicine
title WNT-5A, but not matrix metalloproteinase 3 or b-catenin protein, expression is related to early stages of lip carcinogenesis
spellingShingle WNT-5A, but not matrix metalloproteinase 3 or b-catenin protein, expression is related to early stages of lip carcinogenesis
Xavier, Flávia Caló de Aquino
actinic cheilitis
MMP-3
squamous cell carcinoma
WNT-5A protein
b-catenin
title_short WNT-5A, but not matrix metalloproteinase 3 or b-catenin protein, expression is related to early stages of lip carcinogenesis
title_full WNT-5A, but not matrix metalloproteinase 3 or b-catenin protein, expression is related to early stages of lip carcinogenesis
title_fullStr WNT-5A, but not matrix metalloproteinase 3 or b-catenin protein, expression is related to early stages of lip carcinogenesis
title_full_unstemmed WNT-5A, but not matrix metalloproteinase 3 or b-catenin protein, expression is related to early stages of lip carcinogenesis
title_sort WNT-5A, but not matrix metalloproteinase 3 or b-catenin protein, expression is related to early stages of lip carcinogenesis
author Xavier, Flávia Caló de Aquino
author_facet Xavier, Flávia Caló de Aquino
Rodini, Camila Oliveira
Ramalho, Luciana Maria Pedreira
Mantesso, Andrea
Nunes, Fabio Daumas
author_role author
author2 Rodini, Camila Oliveira
Ramalho, Luciana Maria Pedreira
Mantesso, Andrea
Nunes, Fabio Daumas
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Xavier, Flávia Caló de Aquino
Rodini, Camila Oliveira
Ramalho, Luciana Maria Pedreira
Mantesso, Andrea
Nunes, Fabio Daumas
Xavier, Flávia Caló de Aquino
Rodini, Camila Oliveira
Ramalho, Luciana Maria Pedreira
Mantesso, Andrea
Nunes, Fabio Daumas
dc.subject.por.fl_str_mv actinic cheilitis
MMP-3
squamous cell carcinoma
WNT-5A protein
b-catenin
topic actinic cheilitis
MMP-3
squamous cell carcinoma
WNT-5A protein
b-catenin
description Trabalho completo: acesso restrito, p. 708–715
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2012-06-29T18:01:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6272
dc.identifier.issn.none.fl_str_mv 0904-2512
dc.identifier.number.pt_BR.fl_str_mv v. 38, n. 9
identifier_str_mv 0904-2512
v. 38, n. 9
url http://www.repositorio.ufba.br/ri/handle/ri/6272
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley and Sons
publisher.none.fl_str_mv John Wiley and Sons
dc.source.pt_BR.fl_str_mv http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2009.00756.x/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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instname_str Universidade Federal da Bahia (UFBA)
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