Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil

Bibliographic Details
Main Author: Barbosa, Cynara Gomes
Publication Date: 2008
Other Authors: Souza, Claudio Lima, Moura Neto, José Pereira de, Arruda, Maria da Glória Bomfim, Barreto, José Henrique Silva, Reis, Mitermayer Galvão, Goncalves, Marilda Souza
Format: Article
Language: eng
Source: Repositório Institucional da UFBA
Download full: http://www.repositorio.ufba.br/ri/handle/ri/2619
Summary: p.29-32
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spelling Barbosa, Cynara GomesSouza, Claudio LimaMoura Neto, José Pereira deArruda, Maria da Glória BomfimBarreto, José Henrique SilvaReis, Mitermayer GalvãoGoncalves, Marilda SouzaBarbosa, Cynara GomesSouza, Claudio LimaMoura Neto, José Pereira deArruda, Maria da Glória BomfimBarreto, José Henrique SilvaReis, Mitermayer GalvãoGoncalves, Marilda Souza2011-09-08T18:54:23Z2011-09-08T18:54:23Z20081415-4757http://www.repositorio.ufba.br/ri/handle/ri/261931(1):29-32p.29-32Methylenetetrahydrofolate reductase (MTHFR: EC 1.5.1.20) polymorphisms are associated to acute lymphoid leukemia in different populations. We used the polymerase chain reaction and the restriction fragment length polymorphism method (PCR-RFLP) to investigate MTHFR C677T and A1298C polymorphism frequencies in 67 patients with chronic myeloid leukemia (CML), 27 with acute myeloid leukemia FAB subtype M3 (AML-M3) and 100 apparently healthy controls. The MTHFR mutant allele frequencies were as follows: CML = 17.2% for C677T, 21.6% for A1298C; AML-M3 = 22.2% for C677T, 24.1% for A1298C; and controls = 20.5% for C677T, 21% for A1298C. Taken together, our results provide evidence that MTHFR polymorphisms have no influence on the development of CML or AML-M3.Submitted by Rigaud Andréa (andrearigaud16@yahoo.com.br) on 2011-09-08T18:54:23Z No. of bitstreams: 1 05.pdf: 58187 bytes, checksum: 30a253c79162260253b36ed44e403a3f (MD5)Made available in DSpace on 2011-09-08T18:54:23Z (GMT). No. of bitstreams: 1 05.pdf: 58187 bytes, checksum: 30a253c79162260253b36ed44e403a3f (MD5) Previous issue date: 2008São pauloAMLCMLMTHFR polymorphismsMethylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern BrazilGenetics and Molecular Biologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINAL05.pdf05.pdfapplication/pdf58187https://repositorio.ufba.br/bitstream/ri/2619/1/05.pdf30a253c79162260253b36ed44e403a3fMD51LICENSElicense.txtlicense.txttext/plain1906https://repositorio.ufba.br/bitstream/ri/2619/2/license.txt6175746008a35175a7a2d3b3839650bdMD52TEXT05.pdf.txt05.pdf.txtExtracted texttext/plain15157https://repositorio.ufba.br/bitstream/ri/2619/3/05.pdf.txt34eb5fca94cad0c9b3c12361a6dae390MD53ri/26192022-07-05 14:03:30.508oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:30Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
dc.title.alternative.pt_BR.fl_str_mv Genetics and Molecular Biology
title Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
spellingShingle Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
Barbosa, Cynara Gomes
AML
CML
MTHFR polymorphisms
title_short Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
title_full Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
title_fullStr Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
title_full_unstemmed Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
title_sort Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
author Barbosa, Cynara Gomes
author_facet Barbosa, Cynara Gomes
Souza, Claudio Lima
Moura Neto, José Pereira de
Arruda, Maria da Glória Bomfim
Barreto, José Henrique Silva
Reis, Mitermayer Galvão
Goncalves, Marilda Souza
author_role author
author2 Souza, Claudio Lima
Moura Neto, José Pereira de
Arruda, Maria da Glória Bomfim
Barreto, José Henrique Silva
Reis, Mitermayer Galvão
Goncalves, Marilda Souza
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barbosa, Cynara Gomes
Souza, Claudio Lima
Moura Neto, José Pereira de
Arruda, Maria da Glória Bomfim
Barreto, José Henrique Silva
Reis, Mitermayer Galvão
Goncalves, Marilda Souza
Barbosa, Cynara Gomes
Souza, Claudio Lima
Moura Neto, José Pereira de
Arruda, Maria da Glória Bomfim
Barreto, José Henrique Silva
Reis, Mitermayer Galvão
Goncalves, Marilda Souza
dc.subject.por.fl_str_mv AML
CML
MTHFR polymorphisms
topic AML
CML
MTHFR polymorphisms
description p.29-32
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2011-09-08T18:54:23Z
dc.date.available.fl_str_mv 2011-09-08T18:54:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/2619
dc.identifier.issn.none.fl_str_mv 1415-4757
dc.identifier.number.pt_BR.fl_str_mv 31(1):29-32
identifier_str_mv 1415-4757
31(1):29-32
url http://www.repositorio.ufba.br/ri/handle/ri/2619
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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