Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network

Detalhes bibliográficos
Autor(a) principal: Figueiredo, Camila Alexandrina
Data de Publicação: 2010
Outros Autores: Barreto, Mauricio Lima, Rodrigues, Laura C., Cooper, Philip J., Silva, Nívea Bispo, Amorim, Leila Denise Alves Ferreira, Alcântara-Neves, Neuza Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12735
Resumo: Texto completo: acesso restrito. p.3160-3167
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spelling Figueiredo, Camila AlexandrinaBarreto, Mauricio LimaRodrigues, Laura C.Cooper, Philip J.Silva, Nívea BispoAmorim, Leila Denise Alves FerreiraAlcântara-Neves, Neuza MariaFigueiredo, Camila AlexandrinaBarreto, Mauricio LimaRodrigues, Laura C.Cooper, Philip J.Silva, Nívea BispoAmorim, Leila Denise Alves FerreiraAlcântara-Neves, Neuza Maria2013-08-26T15:11:27Z20100019-9567http://www.repositorio.ufba.br/ri/handle/ri/12735v. 78, n. 7Texto completo: acesso restrito. p.3160-3167Helminth infections have been associated with protection against allergy and autoimmune diseases. We investigated the effects of chronic infections with Ascaris lumbricoides and Trichuris trichiura (measured twice over a 5-year period) on cytokine and antibody responses. We collected blood from 1,060 children aged 4 to 11 years living in a poor urban area of Brazil and measured Th1 (gamma interferon [IFN-γ]) and Th2 (interleukin-5 [IL-5] and IL-13) cytokines and the regulatory cytokine IL-10 in unstimulated and stimulated (with mitogen or A. lumbricoides antigens) cultures of peripheral blood leukocytes and levels of total IgE and anti-A. lumbricoides IgG4 and IgE in serum. Intestinal helminth infections were associated with an increased proportion of children producing IL-5 in response to A. lumbricoides and producing IL-10 spontaneously, especially among coinfected and chronically infected children. Helminth infections were associated with a generalized suppression of cytokine responses to mitogen. Levels of total IgE and anti-A. lumbricoides IgG4 and IgE were especially elevated in chronically infected children. In conclusion, intestinal helminth infections were associated with a typical Th2 immune response profile and with the induction of immune hyporesponsiveness that was associated with greater frequencies of the production of spontaneous IL-10.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-08-26T15:11:27Z No. of bitstreams: 1 Infect. Immun.-2010-Figueiredo-3160-7.pdf: 764823 bytes, checksum: a9219f8d20410b441614a8a8ad700c26 (MD5)Made available in DSpace on 2013-08-26T15:11:27Z (GMT). No. of bitstreams: 1 Infect. Immun.-2010-Figueiredo-3160-7.pdf: 764823 bytes, checksum: a9219f8d20410b441614a8a8ad700c26 (MD5) Previous issue date: 2010http://dx.doi.org/10.1128/IAI.01228-09reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAChronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory networkInfection and Immunityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALInfect. Immun.-2010-Figueiredo-3160-7.pdfInfect. Immun.-2010-Figueiredo-3160-7.pdfapplication/pdf764823https://repositorio.ufba.br/bitstream/ri/12735/1/Infect.%20Immun.-2010-Figueiredo-3160-7.pdfa9219f8d20410b441614a8a8ad700c26MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12735/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTInfect. Immun.-2010-Figueiredo-3160-7.pdf.txtInfect. Immun.-2010-Figueiredo-3160-7.pdf.txtExtracted texttext/plain43552https://repositorio.ufba.br/bitstream/ri/12735/3/Infect.%20Immun.-2010-Figueiredo-3160-7.pdf.txta5f61f178549d000632a08eba3185c08MD53ri/127352022-07-05 14:03:52.236oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:52Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network
dc.title.alternative.pt_BR.fl_str_mv Infection and Immunity
title Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network
spellingShingle Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network
Figueiredo, Camila Alexandrina
title_short Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network
title_full Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network
title_fullStr Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network
title_full_unstemmed Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network
title_sort Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network
author Figueiredo, Camila Alexandrina
author_facet Figueiredo, Camila Alexandrina
Barreto, Mauricio Lima
Rodrigues, Laura C.
Cooper, Philip J.
Silva, Nívea Bispo
Amorim, Leila Denise Alves Ferreira
Alcântara-Neves, Neuza Maria
author_role author
author2 Barreto, Mauricio Lima
Rodrigues, Laura C.
Cooper, Philip J.
Silva, Nívea Bispo
Amorim, Leila Denise Alves Ferreira
Alcântara-Neves, Neuza Maria
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Figueiredo, Camila Alexandrina
Barreto, Mauricio Lima
Rodrigues, Laura C.
Cooper, Philip J.
Silva, Nívea Bispo
Amorim, Leila Denise Alves Ferreira
Alcântara-Neves, Neuza Maria
Figueiredo, Camila Alexandrina
Barreto, Mauricio Lima
Rodrigues, Laura C.
Cooper, Philip J.
Silva, Nívea Bispo
Amorim, Leila Denise Alves Ferreira
Alcântara-Neves, Neuza Maria
description Texto completo: acesso restrito. p.3160-3167
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-08-26T15:11:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12735
dc.identifier.issn.none.fl_str_mv 0019-9567
dc.identifier.number.pt_BR.fl_str_mv v. 78, n. 7
identifier_str_mv 0019-9567
v. 78, n. 7
url http://www.repositorio.ufba.br/ri/handle/ri/12735
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1128/IAI.01228-09
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