Antinociceptive Properties of Bergenin
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5369 |
Resumo: | p. 2062–2068. |
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Oliveira, Cristiane Metzker deNonato, Fabiana ReginaLima, Flávia Oliveira deCouto, Ricardo DavidDavid, Juceni Pereira de LimaDavid, Jorge MauricioSoares, Milena Botelho PereiraVillarreal, Cristiane FloraOliveira, Cristiane Metzker deNonato, Fabiana ReginaLima, Flávia Oliveira deCouto, Ricardo DavidDavid, Juceni Pereira de LimaDavid, Jorge MauricioSoares, Milena Botelho PereiraVillarreal, Cristiane Flora2012-02-09T17:33:09Z2012-02-09T17:33:09Z20111520-6025http://www.repositorio.ufba.br/ri/handle/ri/5369v. 74.p. 2062–2068.Bergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production. The present study was undertaken to evaluate whether 1 has antinociceptive properties in models of inflammatory pain and to investigate its possible mechanisms of action. Pretreatment with 1 (12.5 100 mg/kg, ip) produced a dose-related inhibition of acetic acid-induced writhing in mice. Furthermore, treatment with 1 (50 and 100 mg/kg) inhibited both the early and late phases in a formalin test. In addition, 1 (50 and 100 mg/kg, ip) inhibited mechanical hyperalgesia, edema, and paw production of hyperalgesic cytokines (TNF-α and IL-1β) induced by complete Freund’s adjuvant. However, the local production of IL-10, an anti-inflammatory cytokine, was not altered by 1 (100 mg/kg, ip). Treatment with 1 produced a similar profile of antinociception in wild-type and IL-10-deficient mice. Mice treated with 1 did not show any motor performance alterations or apparent systemic toxicity. The results presented herein demonstrate that bergenin has consistent antinociceptive and anti-inflammatory properties, acting by the inhibition of IL-1β and TNF-α production, and suggest its potential for the control of inflammatory pain.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-02-09T17:33:09Z No. of bitstreams: 1 C__Documents and Settings_rep...9.default_Cache_6_AE_72E54d01.pdf: 292452 bytes, checksum: 1015594383a5013e96da1bca2cd86000 (MD5)Made available in DSpace on 2012-02-09T17:33:09Z (GMT). No. of bitstreams: 1 C__Documents and Settings_rep...9.default_Cache_6_AE_72E54d01.pdf: 292452 bytes, checksum: 1015594383a5013e96da1bca2cd86000 (MD5) Previous issue date: 2011dx.doi.org/10.1021/np200232sreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAntinociceptive Properties of BergeninJournal of Natural Productsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALC__Documents and Settings_rep...9.default_Cache_6_AE_72E54d01.pdfC__Documents and Settings_rep...9.default_Cache_6_AE_72E54d01.pdfapplication/pdf292452https://repositorio.ufba.br/bitstream/ri/5369/1/C__Documents%20and%20Settings_rep...9.default_Cache_6_AE_72E54d01.pdf1015594383a5013e96da1bca2cd86000MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5369/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTC__Documents and Settings_rep...9.default_Cache_6_AE_72E54d01.pdf.txtC__Documents and Settings_rep...9.default_Cache_6_AE_72E54d01.pdf.txtExtracted texttext/plain37380https://repositorio.ufba.br/bitstream/ri/5369/3/C__Documents%20and%20Settings_rep...9.default_Cache_6_AE_72E54d01.pdf.txt743dd5a60a7ce107060e7f6b0e85600aMD53ri/53692022-07-05 14:03:50.531oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Antinociceptive Properties of Bergenin |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Natural Products |
| title |
Antinociceptive Properties of Bergenin |
| spellingShingle |
Antinociceptive Properties of Bergenin Oliveira, Cristiane Metzker de |
| title_short |
Antinociceptive Properties of Bergenin |
| title_full |
Antinociceptive Properties of Bergenin |
| title_fullStr |
Antinociceptive Properties of Bergenin |
| title_full_unstemmed |
Antinociceptive Properties of Bergenin |
| title_sort |
Antinociceptive Properties of Bergenin |
| author |
Oliveira, Cristiane Metzker de |
| author_facet |
Oliveira, Cristiane Metzker de Nonato, Fabiana Regina Lima, Flávia Oliveira de Couto, Ricardo David David, Juceni Pereira de Lima David, Jorge Mauricio Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
| author_role |
author |
| author2 |
Nonato, Fabiana Regina Lima, Flávia Oliveira de Couto, Ricardo David David, Juceni Pereira de Lima David, Jorge Mauricio Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Cristiane Metzker de Nonato, Fabiana Regina Lima, Flávia Oliveira de Couto, Ricardo David David, Juceni Pereira de Lima David, Jorge Mauricio Soares, Milena Botelho Pereira Villarreal, Cristiane Flora Oliveira, Cristiane Metzker de Nonato, Fabiana Regina Lima, Flávia Oliveira de Couto, Ricardo David David, Juceni Pereira de Lima David, Jorge Mauricio Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
| description |
p. 2062–2068. |
| publishDate |
2011 |
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2011 |
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2012-02-09T17:33:09Z |
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2012-02-09T17:33:09Z |
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info:eu-repo/semantics/publishedVersion |
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http://www.repositorio.ufba.br/ri/handle/ri/5369 |
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1520-6025 |
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v. 74. |
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1520-6025 v. 74. |
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eng |
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dx.doi.org/10.1021/np200232s |
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