Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds

Detalhes bibliográficos
Autor(a) principal: Teixeira, Márcia Cristina Aquino
Data de Publicação: 2011
Outros Autores: Silva, Virgínia M. G., Larangeira, Daniela Farias, Oliveira, Pablo R. S., Sampaio, Romina B., Suzart, Paula, Nihei, Jorge S., Mengel, José O., Santos, Washington Luis Conrado dos, Carvalho, Lain Carlos Pontes de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16290
Resumo: Texto completo: acesso restrito. p. 1236-1243
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spelling Teixeira, Márcia Cristina AquinoSilva, Virgínia M. G.Larangeira, Daniela FariasOliveira, Pablo R. S.Sampaio, Romina B.Suzart, PaulaNihei, Jorge S.Mengel, José O.Santos, Washington Luis Conrado dosCarvalho, Lain Carlos Pontes deTeixeira, Márcia Cristina AquinoSilva, Virgínia M. G.Larangeira, Daniela FariasOliveira, Pablo R. S.Sampaio, Romina B.Suzart, PaulaNihei, Jorge S.Mengel, José O.Santos, Washington Luis Conrado dosCarvalho, Lain Carlos Pontes de2014-10-03T19:09:10Z20110019-9567http://repositorio.ufba.br/ri/handle/ri/16290v. 79, n. 3Texto completo: acesso restrito. p. 1236-1243Most inbred strains of mice, like the BALB/c strain, are susceptible to Leishmania amazonensis infections and resistant to Leishmania braziliensis infections. This parasite-related difference could result from the activity of an L. amazonensis-specific virulence factor. In agreement with this hypothesis, it is shown here that the intravenous injection of BALB/c mice with L. amazonensis amastigote extract (LaE) but not the L. braziliensis extract confers susceptibility to L. braziliensis infection. This effect was associated with high circulating levels of IgG1 anti-L. amazonensis antibodies and with an increase in interleukin-4 (IL-4) production and a decrease in gamma interferon production by draining lymph node cells. Moreover, the effect was absent in IL-4-knockout mice. The biological activity in the LaE was not mediated by amphiphilic molecules and was inhibited by pretreatment of the extract with irreversible serine protease inhibitors. These findings indicate that the LaE contains a virulence-related factor that (i) enhances the Leishmania infection by promoting Th2-type immune responses, (ii) is not one of the immunomodulatory Leishmania molecules described so far, and (iii) is either a serine protease or has an effect that depends on that protease activity. In addition to being Leishmania species specific, the infection-enhancing activity was also shown to depend on the host genetic makeup, as LaE injections did not affect the susceptibility of C57BL/6 mice to L. braziliensis infection. The identification of Leishmania molecules with infection-enhancing activity could be important for the development of a vaccine, since the up- or downmodulation of the immune response against a virulence factor could well contribute to controlling the infection.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-08T11:19:54Z No. of bitstreams: 1 Márcia C. A. Teixeira.pdf: 845488 bytes, checksum: 446d66a494b91995feed1ab092cc951e (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-10-03T19:09:09Z (GMT) No. of bitstreams: 1 Márcia C. A. Teixeira.pdf: 845488 bytes, checksum: 446d66a494b91995feed1ab092cc951e (MD5)Made available in DSpace on 2014-10-03T19:09:10Z (GMT). No. of bitstreams: 1 Márcia C. A. Teixeira.pdf: 845488 bytes, checksum: 446d66a494b91995feed1ab092cc951e (MD5) Previous issue date: 2011http://dx.doi.org/ 10.1128/IAI.00309-10reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAEnhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic BackgroundsInfection and Immunityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALMárcia C. A. Teixeira.pdfMárcia C. A. 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dc.title.pt_BR.fl_str_mv Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds
dc.title.alternative.pt_BR.fl_str_mv Infection and Immunity
title Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds
spellingShingle Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds
Teixeira, Márcia Cristina Aquino
title_short Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds
title_full Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds
title_fullStr Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds
title_full_unstemmed Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds
title_sort Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds
author Teixeira, Márcia Cristina Aquino
author_facet Teixeira, Márcia Cristina Aquino
Silva, Virgínia M. G.
Larangeira, Daniela Farias
Oliveira, Pablo R. S.
Sampaio, Romina B.
Suzart, Paula
Nihei, Jorge S.
Mengel, José O.
Santos, Washington Luis Conrado dos
Carvalho, Lain Carlos Pontes de
author_role author
author2 Silva, Virgínia M. G.
Larangeira, Daniela Farias
Oliveira, Pablo R. S.
Sampaio, Romina B.
Suzart, Paula
Nihei, Jorge S.
Mengel, José O.
Santos, Washington Luis Conrado dos
Carvalho, Lain Carlos Pontes de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Teixeira, Márcia Cristina Aquino
Silva, Virgínia M. G.
Larangeira, Daniela Farias
Oliveira, Pablo R. S.
Sampaio, Romina B.
Suzart, Paula
Nihei, Jorge S.
Mengel, José O.
Santos, Washington Luis Conrado dos
Carvalho, Lain Carlos Pontes de
Teixeira, Márcia Cristina Aquino
Silva, Virgínia M. G.
Larangeira, Daniela Farias
Oliveira, Pablo R. S.
Sampaio, Romina B.
Suzart, Paula
Nihei, Jorge S.
Mengel, José O.
Santos, Washington Luis Conrado dos
Carvalho, Lain Carlos Pontes de
description Texto completo: acesso restrito. p. 1236-1243
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-10-03T19:09:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16290
dc.identifier.issn.none.fl_str_mv 0019-9567
dc.identifier.number.pt_BR.fl_str_mv v. 79, n. 3
identifier_str_mv 0019-9567
v. 79, n. 3
url http://repositorio.ufba.br/ri/handle/ri/16290
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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