Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy

Detalhes bibliográficos
Autor(a) principal: Andrade, Luis Jesuino de Oliveira
Data de Publicação: 2010
Outros Autores: Atta, Ajax Mercês, Atta, Maria Luiza Brito de Sousa, Mangabeira, Célia Neder Kalil, Paraná, Raymundo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5281
Resumo: p. 377-381.
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spelling Andrade, Luis Jesuino de OliveiraAtta, Ajax MercêsAtta, Maria Luiza Brito de SousaMangabeira, Célia Neder KalilParaná, RaymundoAndrade, Luis Jesuino de OliveiraAtta, Ajax MercêsAtta, Maria Luiza Brito de SousaMangabeira, Célia Neder KalilParaná, Raymundo2012-01-30T17:45:29Z20101413-8670http://www.repositorio.ufba.br/ri/handle/ri/5281v. 15, n. 4.p. 377-381.OBJECTIVE: To investigate the frequency of thyroid disorders (TD) in patients with chronic hepatitis C before and during interferon-alpha (IFN-α) and ribavirin (RIB) treatment. STUDY DESIGN: Prospective study. PATIENTS AND METHODS: We prospectively studied 65 anti-HCV and viral RNA positive patients. Free thyroxine, thyroid-stimulating hormone, and thyroid peroxidase antibodies (TPO-Ab) were systematically tested at entry (m0), week 12 (m3) and week 24 (m6) of treatment. RESULTS: Mean age of the 65 patients (38 females and 27 males) was 49.61 ± 11.83 years. Seven (10.76%) patients presented baseline thyroid disorders (m0), three had thyroid dysfunction, and four were TPO-Ab positive. Thyroid disorders occurred in the first 12 weeks of treatment in 11 (16.92%) patients, four with thyroid dysfunction, and seven with TPO-Ab positive (m3). A total of 18 patients (27.69%) developed TD after 24 weeks of treatment, 7 with thyroid dysfunction, and 11 with TPO-Ab positive (m6). The relative risk of developing hypothyroidism found in this study was 1.3 (95% CI: 1.1 to 1.6), hyperthyroidism 1.2 (95% CI: 1.1 to 1.4), and TPO-Ab positivity 7.6 (95% CI: 3.9 to 14.5). The study showed a significant association between female sex and thyroid disease (p = 0.009). CONCLUSION: Thyroid dysfunction and autoimmune TD were observed during IFN-α and RIB therapy.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-01-30T17:45:29Z No. of bitstreams: 1 v15n4a13.pdf: 961191 bytes, checksum: 575df8d7f3f73ca3433bf2348a43cc32 (MD5)Made available in DSpace on 2012-01-30T17:45:29Z (GMT). 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dc.title.pt_BR.fl_str_mv Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy
dc.title.alternative.pt_BR.fl_str_mv SciELO - Scientific Electronic Library Online
title Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy
spellingShingle Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy
Andrade, Luis Jesuino de Oliveira
hepatitis C
interferon-alpha
ribavirin
thyroid diseases
autoimmunity
title_short Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy
title_full Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy
title_fullStr Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy
title_full_unstemmed Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy
title_sort Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy
author Andrade, Luis Jesuino de Oliveira
author_facet Andrade, Luis Jesuino de Oliveira
Atta, Ajax Mercês
Atta, Maria Luiza Brito de Sousa
Mangabeira, Célia Neder Kalil
Paraná, Raymundo
author_role author
author2 Atta, Ajax Mercês
Atta, Maria Luiza Brito de Sousa
Mangabeira, Célia Neder Kalil
Paraná, Raymundo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Luis Jesuino de Oliveira
Atta, Ajax Mercês
Atta, Maria Luiza Brito de Sousa
Mangabeira, Célia Neder Kalil
Paraná, Raymundo
Andrade, Luis Jesuino de Oliveira
Atta, Ajax Mercês
Atta, Maria Luiza Brito de Sousa
Mangabeira, Célia Neder Kalil
Paraná, Raymundo
dc.subject.por.fl_str_mv hepatitis C
interferon-alpha
ribavirin
thyroid diseases
autoimmunity
topic hepatitis C
interferon-alpha
ribavirin
thyroid diseases
autoimmunity
description p. 377-381.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-01-30T17:45:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5281
dc.identifier.issn.none.fl_str_mv 1413-8670
dc.identifier.number.pt_BR.fl_str_mv v. 15, n. 4.
identifier_str_mv 1413-8670
v. 15, n. 4.
url http://www.repositorio.ufba.br/ri/handle/ri/5281
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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