Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis

Bibliographic Details
Main Author: Vinhas, Vera Silvia de Freitas
Publication Date: 2007
Other Authors: Andrade, Bruno Bezerril, Paes, Fábio, Bomura, Andréa, Clarencio, Jorge, Miranda, José C., Báfica, Andre Luiz Barbosa, Barral, Aldina Maria Prado, Barral-Netto, Manoel
Format: Article
Language: eng
Source: Repositório Institucional da UFBA
Download full: http://repositorio.ufba.br/ri/handle/ri/14316
Summary: Texto completo: acesso restrito. p. 3111-3121
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spelling Vinhas, Vera Silvia de FreitasAndrade, Bruno BezerrilPaes, FábioBomura, AndréaClarencio, JorgeMiranda, José C.Báfica, Andre Luiz BarbosaBarral, Aldina Maria PradoBarral-Netto, ManoelVinhas, Vera Silvia de FreitasAndrade, Bruno BezerrilPaes, FábioBomura, AndréaClarencio, JorgeMiranda, José C.Báfica, Andre Luiz BarbosaBarral, Aldina Maria PradoBarral-Netto, Manoel2014-01-10T16:38:50Z20070014-2980http://repositorio.ufba.br/ri/handle/ri/14316v. 37, n. 11Texto completo: acesso restrito. p. 3111-3121Experiments in animals verified that phlebotomine saliva enhances Leishmania infection, and vaccination with saliva prevents disease. We have shown that individuals from an endemic area of visceral leishmaniasis displayed robust antibody responses to saliva from the vector Lutzomyialongipalpis, which correlated with anti-parasite cell-mediated immunity. Here, we explored human anti-saliva responses following exposure to sand flies, using an in vivo bite model in which normal volunteers were exposed four times to 30 laboratory-reared Lu. longipalpis. Following the third exposure, normal volunteers developed diverse dermatological reactions at the site of insect bite. Serum from normal volunteers displayed high levels of anti-salivary gland sonicate IgG1, IgG4 and IgE as well as several salivary gland proteins. Furthermore, following in vitro stimulation with salivary gland sonicate, there was an increased frequency of CD4+CD25+ and CD8+CD25+ T cells as well as IFN-γ and IL-10 synthesis. Strikingly, 1 year after the first exposure, PBMC from the volunteers displayed recall IFN-γ responses that correlated with a significant reduction in infection rates using a macrophage-lymphocyte autologous culture. Together, these data suggest that human immunization against sand fly saliva is feasible and recall responses are obtained even 1 year after exposure, opening perspectives for vaccination in man.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-10T14:57:03Z No. of bitstreams: 1 10.1002-eji.200737431.pdf: 347167 bytes, checksum: 54a24ccf2c3aab33b0ff6aebd5613dc7 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-10T16:38:50Z (GMT) No. of bitstreams: 1 10.1002-eji.200737431.pdf: 347167 bytes, checksum: 54a24ccf2c3aab33b0ff6aebd5613dc7 (MD5)Made available in DSpace on 2014-01-10T16:38:50Z (GMT). No. of bitstreams: 1 10.1002-eji.200737431.pdf: 347167 bytes, checksum: 54a24ccf2c3aab33b0ff6aebd5613dc7 (MD5) Previous issue date: 2007http://dx.doi.org/10.1002/eji.200737431reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACytokinesHumanSalivaSand flyHuman anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpisEuropean Journal of Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL10.1002-eji.200737431.pdf10.1002-eji.200737431.pdfapplication/pdf347167https://repositorio.ufba.br/bitstream/ri/14316/1/10.1002-eji.200737431.pdf54a24ccf2c3aab33b0ff6aebd5613dc7MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14316/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT10.1002-eji.200737431.pdf.txt10.1002-eji.200737431.pdf.txtExtracted texttext/plain44807https://repositorio.ufba.br/bitstream/ri/14316/3/10.1002-eji.200737431.pdf.txt49e6f48e893cede3d20c9220f60f4371MD53ri/143162022-07-05 14:03:46.56oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:46Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis
dc.title.alternative.pt_BR.fl_str_mv European Journal of Immunology
title Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis
spellingShingle Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis
Vinhas, Vera Silvia de Freitas
Cytokines
Human
Saliva
Sand fly
title_short Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis
title_full Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis
title_fullStr Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis
title_full_unstemmed Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis
title_sort Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis
author Vinhas, Vera Silvia de Freitas
author_facet Vinhas, Vera Silvia de Freitas
Andrade, Bruno Bezerril
Paes, Fábio
Bomura, Andréa
Clarencio, Jorge
Miranda, José C.
Báfica, Andre Luiz Barbosa
Barral, Aldina Maria Prado
Barral-Netto, Manoel
author_role author
author2 Andrade, Bruno Bezerril
Paes, Fábio
Bomura, Andréa
Clarencio, Jorge
Miranda, José C.
Báfica, Andre Luiz Barbosa
Barral, Aldina Maria Prado
Barral-Netto, Manoel
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vinhas, Vera Silvia de Freitas
Andrade, Bruno Bezerril
Paes, Fábio
Bomura, Andréa
Clarencio, Jorge
Miranda, José C.
Báfica, Andre Luiz Barbosa
Barral, Aldina Maria Prado
Barral-Netto, Manoel
Vinhas, Vera Silvia de Freitas
Andrade, Bruno Bezerril
Paes, Fábio
Bomura, Andréa
Clarencio, Jorge
Miranda, José C.
Báfica, Andre Luiz Barbosa
Barral, Aldina Maria Prado
Barral-Netto, Manoel
dc.subject.por.fl_str_mv Cytokines
Human
Saliva
Sand fly
topic Cytokines
Human
Saliva
Sand fly
description Texto completo: acesso restrito. p. 3111-3121
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-01-10T16:38:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14316
dc.identifier.issn.none.fl_str_mv 0014-2980
dc.identifier.number.pt_BR.fl_str_mv v. 37, n. 11
identifier_str_mv 0014-2980
v. 37, n. 11
url http://repositorio.ufba.br/ri/handle/ri/14316
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1002/eji.200737431
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