Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma

Bibliographic Details
Main Author: Oliveira, Marília Gerhardt de
Publication Date: 2012
Other Authors: Ramalho, Luciana Maria Pedreira, Melo, Lêonilson Gaião de, Pozza, Daniel Humberto, Mello, Ramon Andrade de
Format: Article
Language: eng
Source: Repositório Institucional da UFBA
Download full: http://repositorio.ufba.br/ri/handle/ri/16370
Summary: Texto completo: acesso restrito. p. 163-166
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spelling Oliveira, Marília Gerhardt deRamalho, Luciana Maria PedreiraMelo, Lêonilson Gaião dePozza, Daniel HumbertoMello, Ramon Andrade deOliveira, Marília Gerhardt deRamalho, Luciana Maria PedreiraMelo, Lêonilson Gaião dePozza, Daniel HumbertoMello, Ramon Andrade de2014-10-10T14:25:37Z20121791-2997http://repositorio.ufba.br/ri/handle/ri/16370v. 6, n. 1Texto completo: acesso restrito. p. 163-166The retinoblastoma (Rb) and p53 genes play a fundamental role in cell cycle mechanisms, and their deregulation is related to many steps of oral cancer carcinogenesis. This study was conducted to evaluate the expression of the p53 and Rb proteins in malignant and pre-malignant oral cavity lesions. This retrospective study was conducted at the Federal University of Bahia, Salvador, Brazil, and the Molecular Biology Laboratory of the Otorhinolaryngology Department at the University of Heidelberg, Heidelberg, Germany. Excisional biopsy samples of oral cavities were collected from patients with suspected oral lesions. The samples were processed by immunohistochemistry to be classified by a semi-quantitative score: samples with a ≤10% positivity were considered to have weak/negative expression (-); those with 11-50% positivity, moderate expression (+); and those with >50% positivity, high expression (++). Seventy-one patients were studied (75% male; median age, 52 years; range, 24-84). Of the samples studied, 59.4% were oral squamous cell carcinoma (OSCC) and 40.6% were pre-neoplastic lesions (leukoplakia and actinic cheilitis). OSCC presented higher expression of Rb protein compared to pre-malignant lesions: 75 vs. 25% (p<0.001). Pre-neoplastic lesions presented higher expression of p53 protein compared to OSCC lesions: 55.2 vs. 44.8% (p=0.030). Despite the small number of samples, the expression of these cell cycle biomarkers (p53 and Rb protein) in excisional biopsies suggests that molecular lesion assessment can determine pre-malignant lesions, and that its use may improve the clinical and surgical treatment of early lesions. Thus, p53 protein expression may be related to the early steps of carcinogenesis in OSCC. Finally, a higher Rb expression was also observed in malignant lesions.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-04T14:05:49Z No. of bitstreams: 1 Marília Gerhardt de Oliveira.pdf: 547839 bytes, checksum: 19744602ba2487603f2a6dd7f3cf5986 (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-10-10T14:25:37Z (GMT) No. of bitstreams: 1 Marília Gerhardt de Oliveira.pdf: 547839 bytes, checksum: 19744602ba2487603f2a6dd7f3cf5986 (MD5)Made available in DSpace on 2014-10-10T14:25:37Z (GMT). No. of bitstreams: 1 Marília Gerhardt de Oliveira.pdf: 547839 bytes, checksum: 19744602ba2487603f2a6dd7f3cf5986 (MD5) Previous issue date: 2012http://dx.doi.org/10.3892/mmr.2012.876reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBARetinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinomaMolecular Medicine Reportsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALMarília Gerhardt de Oliveira.pdfMarília Gerhardt de Oliveira.pdfapplication/pdf547839https://repositorio.ufba.br/bitstream/ri/16370/1/Mar%c3%adlia%20Gerhardt%20de%20Oliveira.pdf19744602ba2487603f2a6dd7f3cf5986MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16370/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTMarília Gerhardt de Oliveira.pdf.txtMarília Gerhardt de Oliveira.pdf.txtExtracted texttext/plain22553https://repositorio.ufba.br/bitstream/ri/16370/3/Mar%c3%adlia%20Gerhardt%20de%20Oliveira.pdf.txtecf294175a30b085452fdd6a99c11480MD53ri/163702022-07-05 14:03:33.233oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:33Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma
dc.title.alternative.pt_BR.fl_str_mv Molecular Medicine Reports
title Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma
spellingShingle Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma
Oliveira, Marília Gerhardt de
title_short Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma
title_full Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma
title_fullStr Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma
title_full_unstemmed Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma
title_sort Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma
author Oliveira, Marília Gerhardt de
author_facet Oliveira, Marília Gerhardt de
Ramalho, Luciana Maria Pedreira
Melo, Lêonilson Gaião de
Pozza, Daniel Humberto
Mello, Ramon Andrade de
author_role author
author2 Ramalho, Luciana Maria Pedreira
Melo, Lêonilson Gaião de
Pozza, Daniel Humberto
Mello, Ramon Andrade de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Marília Gerhardt de
Ramalho, Luciana Maria Pedreira
Melo, Lêonilson Gaião de
Pozza, Daniel Humberto
Mello, Ramon Andrade de
Oliveira, Marília Gerhardt de
Ramalho, Luciana Maria Pedreira
Melo, Lêonilson Gaião de
Pozza, Daniel Humberto
Mello, Ramon Andrade de
description Texto completo: acesso restrito. p. 163-166
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-10-10T14:25:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16370
dc.identifier.issn.none.fl_str_mv 1791-2997
dc.identifier.number.pt_BR.fl_str_mv v. 6, n. 1
identifier_str_mv 1791-2997
v. 6, n. 1
url http://repositorio.ufba.br/ri/handle/ri/16370
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.3892/mmr.2012.876
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
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