Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in Northeastern Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/12773 |
Resumo: | p. 1-6 |
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Bastos, Claudilson Jose de CarvalhoAras Júnior, RoqueMota, GildoReis, FranciscoDias, Juarez PereiraJesus, Robson Silva deFreire, Miralba SilvaAraújo, Eline Gomes dePrazeres, JulianaGrassi, Maria Fernanda RiosBastos, Claudilson Jose de CarvalhoAras Júnior, RoqueMota, GildoReis, FranciscoDias, Juarez PereiraJesus, Robson Silva deFreire, Miralba SilvaAraújo, Eline Gomes dePrazeres, JulianaGrassi, Maria Fernanda Rios2013-08-28T17:28:17Z2013-08-28T17:28:17Z20101935-2727http://www.repositorio.ufba.br/ri/handle/ri/12773v. 4, n. 6p. 1-6Background: Outbreaks of orally transmitted Trypanosoma cruzi continue to be reported in Brazil and are associated with a high mortality rate, mainly due to myocarditis. Methods: This study is a detailed report on the disease progression of acute Chagas disease in 13 patients who were infected during two micro-outbreaks in two northeastern Brazilian towns. Clinical outcomes as well as EKG and ECHO results are described, both before and after benznidazole treatment. Results: Fever and dyspnea were the most frequent symptoms observed. Other clinical findings included myalgia, periorbital edema, headache and systolic murmur. Two patients died of cardiac failure before receiving benznidazole treatment. EKG and ECHO findings frequently showed a disturbance in ventricular repolarization and pericardial effusion. Ventricular dysfunction (ejection fraction <55%) was present in 27.3% of patients. After treatment, EKG readings normalized in 91.7% of patients. Ventricular repolarization abnormalities persisted in 50% of the patients, while sinus bradycardia was observed in 18%. The systolic ejection fraction normalized in two out of three patients with initially depressed ventricular function, while pericardial effusion disappeared. Conclusions: Myocarditis is frequently found and potentially severe in patients with acute Chagas disease. Benznidazole treatment may improve clinical symptoms, as well as EKG and ECHO findings.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-08-28T12:39:07Z No. of bitstreams: 1 pntd.0000711-1.pdf: 871705 bytes, checksum: 1cbb85d22a1b922097ab31ddf49fc584 (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-08-28T17:28:17Z (GMT) No. of bitstreams: 1 pntd.0000711-1.pdf: 871705 bytes, checksum: 1cbb85d22a1b922097ab31ddf49fc584 (MD5)Made available in DSpace on 2013-08-28T17:28:17Z (GMT). No. of bitstreams: 1 pntd.0000711-1.pdf: 871705 bytes, checksum: 1cbb85d22a1b922097ab31ddf49fc584 (MD5) Previous issue date: 2010http://dx.doi.org/10.1371/journal.pntd.0000711reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAChagas DiseaseTrypanosoma cruziMortality RateChagas CardiomyopathyClinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in Northeastern BrazilPLoS Neglected Tropical Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALpntd.0000711-1.pdfpntd.0000711-1.pdfapplication/pdf871705https://repositorio.ufba.br/bitstream/ri/12773/1/pntd.0000711-1.pdf1cbb85d22a1b922097ab31ddf49fc584MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12773/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTpntd.0000711-1.pdf.txtpntd.0000711-1.pdf.txtExtracted texttext/plain33079https://repositorio.ufba.br/bitstream/ri/12773/3/pntd.0000711-1.pdf.txt0634cb05bf707ae838a9c965d08fbc01MD53ri/127732022-07-05 14:02:49.331oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:49Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in Northeastern Brazil |
| dc.title.alternative.pt_BR.fl_str_mv |
PLoS Neglected Tropical Diseases |
| title |
Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in Northeastern Brazil |
| spellingShingle |
Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in Northeastern Brazil Bastos, Claudilson Jose de Carvalho Chagas Disease Trypanosoma cruzi Mortality Rate Chagas Cardiomyopathy |
| title_short |
Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in Northeastern Brazil |
| title_full |
Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in Northeastern Brazil |
| title_fullStr |
Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in Northeastern Brazil |
| title_full_unstemmed |
Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in Northeastern Brazil |
| title_sort |
Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in Northeastern Brazil |
| author |
Bastos, Claudilson Jose de Carvalho |
| author_facet |
Bastos, Claudilson Jose de Carvalho Aras Júnior, Roque Mota, Gildo Reis, Francisco Dias, Juarez Pereira Jesus, Robson Silva de Freire, Miralba Silva Araújo, Eline Gomes de Prazeres, Juliana Grassi, Maria Fernanda Rios |
| author_role |
author |
| author2 |
Aras Júnior, Roque Mota, Gildo Reis, Francisco Dias, Juarez Pereira Jesus, Robson Silva de Freire, Miralba Silva Araújo, Eline Gomes de Prazeres, Juliana Grassi, Maria Fernanda Rios |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bastos, Claudilson Jose de Carvalho Aras Júnior, Roque Mota, Gildo Reis, Francisco Dias, Juarez Pereira Jesus, Robson Silva de Freire, Miralba Silva Araújo, Eline Gomes de Prazeres, Juliana Grassi, Maria Fernanda Rios Bastos, Claudilson Jose de Carvalho Aras Júnior, Roque Mota, Gildo Reis, Francisco Dias, Juarez Pereira Jesus, Robson Silva de Freire, Miralba Silva Araújo, Eline Gomes de Prazeres, Juliana Grassi, Maria Fernanda Rios |
| dc.subject.por.fl_str_mv |
Chagas Disease Trypanosoma cruzi Mortality Rate Chagas Cardiomyopathy |
| topic |
Chagas Disease Trypanosoma cruzi Mortality Rate Chagas Cardiomyopathy |
| description |
p. 1-6 |
| publishDate |
2010 |
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2010 |
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2013-08-28T17:28:17Z |
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2013-08-28T17:28:17Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://www.repositorio.ufba.br/ri/handle/ri/12773 |
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1935-2727 |
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v. 4, n. 6 |
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1935-2727 v. 4, n. 6 |
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http://www.repositorio.ufba.br/ri/handle/ri/12773 |
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