Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Machado, Paulo Roberto Lima
Data de Publicação: 2007
Outros Autores: Lessa, Hélio Andrade, Lessa, Marcus, Guimarães, Luiz H., Bang, Heejung, Ho, John L., Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16014
Resumo: Texto completo: acesso restrito. p. 788-793
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spelling Machado, Paulo Roberto LimaLessa, Hélio AndradeLessa, MarcusGuimarães, Luiz H.Bang, HeejungHo, John L.Carvalho Filho, Edgar Marcelino deMachado, Paulo Roberto LimaLessa, Hélio AndradeLessa, MarcusGuimarães, Luiz H.Bang, HeejungHo, John L.Carvalho Filho, Edgar Marcelino de2014-09-09T16:15:25Z20071058-4838http://repositorio.ufba.br/ri/handle/ri/16014v. 44, n. 6Texto completo: acesso restrito. p. 788-793Background. Mucosal leishmaniasis is associated with intense tissue damage and high tumor necrosis factor–α production. Therapeutic failure occurs in up to 42% of cases; patients who experience treatment failure will require >1 pentavalent antimony (Sbv) course or alternative drugs to achieve a cure. We previously showed that an inhibitor of tumor necrosis factor–α (pentoxifylline) combined with Sbv cured 90% patients refractory to monotherapy with Sbv. Methods. A double-blind, placebo-controlled trial involving 23 patients with mucosal leishmaniasis evaluated the efficacy of pentoxifylline when administered in association with Sbv, compared with Sbv treatment alone. Eleven patients were randomized to receive Sbv plus oral pentoxifylline for 30 days, and 12 patients received Sbv plus oral placebo. The criterion for cure was a complete healing of lesions. Results. All patients in the pentoxifylline group experienced a cure with 1 course of Sbv, whereas 5 (41.6%) of 12 patients in the placebo group required a second course of Sbv (P = .037). The healing time ± standard deviation in the pentoxifylline group was 83 ± 36 days, compared with 145 ± 99 days in the placebo group (P = .049). No relapses were documented in either group at the 2-year follow-up visit. Conclusions. The addition of pentoxifylline to Sbv in mucosal leishmaniasis reduces the healing time significantly and prevents the need for further courses of Sbv.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-31T15:27:27Z No. of bitstreams: 1 10.1086-511643.pdf: 148831 bytes, checksum: f27d89c43b44be61ee73ba5de58ceaac (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T16:15:25Z (GMT) No. of bitstreams: 1 10.1086-511643.pdf: 148831 bytes, checksum: f27d89c43b44be61ee73ba5de58ceaac (MD5)Made available in DSpace on 2014-09-09T16:15:25Z (GMT). No. of bitstreams: 1 10.1086-511643.pdf: 148831 bytes, checksum: f27d89c43b44be61ee73ba5de58ceaac (MD5) Previous issue date: 2007http://dx.doi.org/10.1086/511643reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAOral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasisClinical Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL10.1086-511643.pdf10.1086-511643.pdfapplication/pdf148831https://repositorio.ufba.br/bitstream/ri/16014/1/10.1086-511643.pdff27d89c43b44be61ee73ba5de58ceaacMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16014/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT10.1086-511643.pdf.txt10.1086-511643.pdf.txtExtracted texttext/plain26615https://repositorio.ufba.br/bitstream/ri/16014/3/10.1086-511643.pdf.txt539b85d2251c9b86fb2c110a1a3dc0ecMD53ri/160142022-07-05 14:03:00.049oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis
dc.title.alternative.pt_BR.fl_str_mv Clinical Infectious Diseases
title Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis
spellingShingle Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis
Machado, Paulo Roberto Lima
title_short Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis
title_full Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis
title_fullStr Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis
title_full_unstemmed Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis
title_sort Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis
author Machado, Paulo Roberto Lima
author_facet Machado, Paulo Roberto Lima
Lessa, Hélio Andrade
Lessa, Marcus
Guimarães, Luiz H.
Bang, Heejung
Ho, John L.
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Lessa, Hélio Andrade
Lessa, Marcus
Guimarães, Luiz H.
Bang, Heejung
Ho, John L.
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Machado, Paulo Roberto Lima
Lessa, Hélio Andrade
Lessa, Marcus
Guimarães, Luiz H.
Bang, Heejung
Ho, John L.
Carvalho Filho, Edgar Marcelino de
Machado, Paulo Roberto Lima
Lessa, Hélio Andrade
Lessa, Marcus
Guimarães, Luiz H.
Bang, Heejung
Ho, John L.
Carvalho Filho, Edgar Marcelino de
description Texto completo: acesso restrito. p. 788-793
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-09-09T16:15:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16014
dc.identifier.issn.none.fl_str_mv 1058-4838
dc.identifier.number.pt_BR.fl_str_mv v. 44, n. 6
identifier_str_mv 1058-4838
v. 44, n. 6
url http://repositorio.ufba.br/ri/handle/ri/16014
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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