Anti-inflammatory properties of rose oxide

Detalhes bibliográficos
Autor(a) principal: Villarreal, Cristiane Flora
Data de Publicação: 2012
Outros Autores: Melo, Flavielle Martins de, Nonato, Fabiana Regina, Santana, Daniele Gomes, Santos, Gisele Graça Leite dos, Brustolim, Daniele, Camargo, Enilton Aparecido, Sousa, Damião P. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16065
Resumo: Texto completo: acesso restrito. p. 779–784
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spelling Villarreal, Cristiane FloraMelo, Flavielle Martins deNonato, Fabiana ReginaSantana, Daniele GomesSantos, Gisele Graça Leite dosBrustolim, DanieleCamargo, Enilton AparecidoSousa, Damião P. deVillarreal, Cristiane FloraMelo, Flavielle Martins deNonato, Fabiana ReginaSantana, Daniele GomesSantos, Gisele Graça Leite dosBrustolim, DanieleCamargo, Enilton AparecidoSousa, Damião P. de2014-09-11T18:13:35Z20121567-5769http://repositorio.ufba.br/ri/handle/ri/16065v. 14, n. 4Texto completo: acesso restrito. p. 779–784Rose-oxide is a fragrance found in roses and rose oil. There are no reports about the pharmacological activity of this molecule. The present study was undertaken to evaluate whether rose-oxide (RO) has anti-inflammatory properties and to investigate possible mechanisms involved with its effects. The anti-inflammatory activity of RO was first suggested by the formalin test in mice, an inflammatory pain model, because intraperitoneal (i.p.) administration of RO (50 and 100 mg/kg) inhibited only the late phase of this test. To further investigate the anti-inflammatory properties of RO, the complete Freund's adjuvant (CFA)- and carrageenan-induced paw inflammation models were used. Pre-treatment with RO (50 and 100 mg/kg) significantly reduced paw edema at 4, 6 and 24 h after the CFA injection. In addition, RO (100 mg/kg) reduced the IL-1β, but not TNF-α, local production induced by CFA. Administration of RO (25–100 mg/kg) decreased the paw edema induced by carrageenan in rats, which was more evident at 3 and 4 h after induction. In addition, neutrophil migration to the hind paw was measured by MPO assay after the carrageenan injection. The MPO activity was significantly inhibited by RO at 25–100 mg/kg, 4 h after stimulus. In another experimental set, administration of RO (25–100 mg/kg) significantly reduced the leukocyte migration in the carrageenan-induced peritonitis model in mice. The results described here are the first report of pharmacological properties of RO and strongly suggest that RO possesses anti-inflammatory activity related to its ability to inhibit the IL-1β production and the leukocyte migration.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-29T15:14:49Z No. of bitstreams: 1 Cristiane Flora Villarreal.pdf: 514931 bytes, checksum: 14769cc91d175162ca0896db2847d9cc (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-09-11T18:13:34Z (GMT) No. of bitstreams: 1 Cristiane Flora Villarreal.pdf: 514931 bytes, checksum: 14769cc91d175162ca0896db2847d9cc (MD5)Made available in DSpace on 2014-09-11T18:13:35Z (GMT). No. of bitstreams: 1 Cristiane Flora Villarreal.pdf: 514931 bytes, checksum: 14769cc91d175162ca0896db2847d9cc (MD5) Previous issue date: 2012http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.intimp.2012.10.015reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAEssential oilsMonoterpenesAnti-inflammatoryCytokinesAnti-inflammatory properties of rose oxideInternational Immunopharmacologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALCristiane Flora Villarreal.pdfCristiane Flora Villarreal.pdfapplication/pdf514931https://repositorio.ufba.br/bitstream/ri/16065/1/Cristiane%20Flora%20Villarreal.pdf14769cc91d175162ca0896db2847d9ccMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16065/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTCristiane Flora Villarreal.pdf.txtCristiane Flora Villarreal.pdf.txtExtracted texttext/plain36109https://repositorio.ufba.br/bitstream/ri/16065/3/Cristiane%20Flora%20Villarreal.pdf.txte465607f10700c8aff95a36d72b122bbMD53ri/160652022-07-05 14:03:44.29oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:44Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Anti-inflammatory properties of rose oxide
dc.title.alternative.pt_BR.fl_str_mv International Immunopharmacology
title Anti-inflammatory properties of rose oxide
spellingShingle Anti-inflammatory properties of rose oxide
Villarreal, Cristiane Flora
Essential oils
Monoterpenes
Anti-inflammatory
Cytokines
title_short Anti-inflammatory properties of rose oxide
title_full Anti-inflammatory properties of rose oxide
title_fullStr Anti-inflammatory properties of rose oxide
title_full_unstemmed Anti-inflammatory properties of rose oxide
title_sort Anti-inflammatory properties of rose oxide
author Villarreal, Cristiane Flora
author_facet Villarreal, Cristiane Flora
Melo, Flavielle Martins de
Nonato, Fabiana Regina
Santana, Daniele Gomes
Santos, Gisele Graça Leite dos
Brustolim, Daniele
Camargo, Enilton Aparecido
Sousa, Damião P. de
author_role author
author2 Melo, Flavielle Martins de
Nonato, Fabiana Regina
Santana, Daniele Gomes
Santos, Gisele Graça Leite dos
Brustolim, Daniele
Camargo, Enilton Aparecido
Sousa, Damião P. de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Villarreal, Cristiane Flora
Melo, Flavielle Martins de
Nonato, Fabiana Regina
Santana, Daniele Gomes
Santos, Gisele Graça Leite dos
Brustolim, Daniele
Camargo, Enilton Aparecido
Sousa, Damião P. de
Villarreal, Cristiane Flora
Melo, Flavielle Martins de
Nonato, Fabiana Regina
Santana, Daniele Gomes
Santos, Gisele Graça Leite dos
Brustolim, Daniele
Camargo, Enilton Aparecido
Sousa, Damião P. de
dc.subject.por.fl_str_mv Essential oils
Monoterpenes
Anti-inflammatory
Cytokines
topic Essential oils
Monoterpenes
Anti-inflammatory
Cytokines
description Texto completo: acesso restrito. p. 779–784
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-09-11T18:13:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16065
dc.identifier.issn.none.fl_str_mv 1567-5769
dc.identifier.number.pt_BR.fl_str_mv v. 14, n. 4
identifier_str_mv 1567-5769
v. 14, n. 4
url http://repositorio.ufba.br/ri/handle/ri/16065
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.intimp.2012.10.015
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reponame_str Repositório Institucional da UFBA
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