Transplantation of bone marrow cells decreases tumor necrosis factor-α production and blood–brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/16361 |
Resumo: | Texto completo: acesso restrito. p. 1011–1021 |
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Souza, Bruno Solano de FreitasNascimento, Ramon CamposOliveira, Sheilla Andrade deVasconcelos, Juliana FragaKaneto, Carla MartinsCarvalho, Lian Felipe Paiva Pontes deSantos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraFreitas, Luiz Antônio Rodrigues deSouza, Bruno Solano de FreitasNascimento, Ramon CamposOliveira, Sheilla Andrade deVasconcelos, Juliana FragaKaneto, Carla MartinsCarvalho, Lian Felipe Paiva Pontes deSantos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraFreitas, Luiz Antônio Rodrigues de2014-10-09T15:45:53Z20121465-3249http://repositorio.ufba.br/ri/handle/ri/16361v. 14, n. 8Texto completo: acesso restrito. p. 1011–1021Background aims Acute liver failure (ALF), although rare, remains a rapidly progressive and frequently fatal condition. Acetaminophen (APAP) poisoning induces a massive hepatic necrosis and often leads to death as a result of cerebral edema. Cell-based therapies are currently being investigated for liver injuries. We evaluated the therapeutic potential of transplantation of bone marrow mononuclear cells (BMC) in a mouse model of acute liver injury. Methods ALF was induced in C57Bl/6 mice submitted to an alcoholic diet followed by fasting and injection of APAP. Mice were transplanted with 107 BMC obtained from enhanced green fluorescent protein (GFP) transgenic mice. Results BMC transplantation caused a significant reduction in APAP-induced mortality. However, no significant differences in serum aminotransferase concentrations, extension of liver necrosis, number of inflammatory cells and levels of cytokines in the liver were found when BMC- and saline-injected groups were compared. Moreover, recruitment of transplanted cells to the liver was very low and no donor-derived hepatocytes were observed. Mice submitted to BMC therapy had some protection against disruption of the blood–brain barrier, despite their hyperammonemia, and serum metalloproteinase (MMP)-9 activity similar to the saline-injected group. Tumor necrosis factor (TNF)-α concentrations were decreased in the serum of BMC-treated mice. This reduction was associated with an early increase in interleukin (IL)-10 mRNA expression in the spleen and bone marrow after BMC treatment. Conclusions BMC transplantation protects mice submitted to high doses of APAP and is a potential candidate for ALF treatment, probably via an immunomodulatory effect on TNF-α production.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-07-15T15:53:39Z No. of bitstreams: 1 Luiz Antônio Rodrigues de Freitas.pdf: 1068341 bytes, checksum: d48e47b2f4ec8b947c4ee5717afa8049 (MD5)Rejected by Flávia Ferreira (flaviaccf@yahoo.com.br), reason: Bom dia Por favor efetue cadastro de autores na ordem em que aparece no artigo: Souza,Bruno Solano de Freitas Nascimento,Ramon Campos Oliveira,Sheilla Andrade de Vasconcelos,Juliana Fraga Kaneto,Carla Martins Carvalho,Lian Felipe Paiva Pontes de Santos,Ricardo Ribeiro dos Soares, Milena Botelho Pereira Freitas, Luiz Antonio Rodrigues de Equipe RI Gratos, on 2014-08-07T13:20:42Z (GMT)Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-11T11:32:08Z No. of bitstreams: 1 BRUNO SOLANO DE FREITAS SOUZA.pdf: 1068341 bytes, checksum: d48e47b2f4ec8b947c4ee5717afa8049 (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-10-09T15:45:53Z (GMT) No. of bitstreams: 1 BRUNO SOLANO DE FREITAS SOUZA.pdf: 1068341 bytes, checksum: d48e47b2f4ec8b947c4ee5717afa8049 (MD5)Made available in DSpace on 2014-10-09T15:45:53Z (GMT). No. of bitstreams: 1 BRUNO SOLANO DE FREITAS SOUZA.pdf: 1068341 bytes, checksum: d48e47b2f4ec8b947c4ee5717afa8049 (MD5) Previous issue date: 2012http://dx.doi.org/10.3109/14653249.2012.684445reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAcetaminophenAcute liver failureBone marrow mononuclear cellsBrain edemaCell therapyTumor necrosis factorTransplantation of bone marrow cells decreases tumor necrosis factor-α production and blood–brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver diseaseCytotherapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALBRUNO SOLANO DE FREITAS SOUZA.pdfBRUNO SOLANO DE FREITAS SOUZA.pdfapplication/pdf1068341https://repositorio.ufba.br/bitstream/ri/16361/3/BRUNO%20SOLANO%20DE%20FREITAS%20SOUZA.pdfd48e47b2f4ec8b947c4ee5717afa8049MD53LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16361/4/license.txtff6eaa8b858ea317fded99f125f5fcd0MD54TEXTBRUNO SOLANO DE FREITAS SOUZA.pdf.txtBRUNO SOLANO DE FREITAS SOUZA.pdf.txtExtracted texttext/plain39106https://repositorio.ufba.br/bitstream/ri/16361/5/BRUNO%20SOLANO%20DE%20FREITAS%20SOUZA.pdf.txt211e558c087a9937034a998cb7fce86cMD55ri/163612022-07-05 14:04:14.81oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:14Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Transplantation of bone marrow cells decreases tumor necrosis factor-α production and blood–brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease |
| dc.title.alternative.pt_BR.fl_str_mv |
Cytotherapy |
| title |
Transplantation of bone marrow cells decreases tumor necrosis factor-α production and blood–brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease |
| spellingShingle |
Transplantation of bone marrow cells decreases tumor necrosis factor-α production and blood–brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease Souza, Bruno Solano de Freitas Acetaminophen Acute liver failure Bone marrow mononuclear cells Brain edema Cell therapy Tumor necrosis factor |
| title_short |
Transplantation of bone marrow cells decreases tumor necrosis factor-α production and blood–brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease |
| title_full |
Transplantation of bone marrow cells decreases tumor necrosis factor-α production and blood–brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease |
| title_fullStr |
Transplantation of bone marrow cells decreases tumor necrosis factor-α production and blood–brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease |
| title_full_unstemmed |
Transplantation of bone marrow cells decreases tumor necrosis factor-α production and blood–brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease |
| title_sort |
Transplantation of bone marrow cells decreases tumor necrosis factor-α production and blood–brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease |
| author |
Souza, Bruno Solano de Freitas |
| author_facet |
Souza, Bruno Solano de Freitas Nascimento, Ramon Campos Oliveira, Sheilla Andrade de Vasconcelos, Juliana Fraga Kaneto, Carla Martins Carvalho, Lian Felipe Paiva Pontes de Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Freitas, Luiz Antônio Rodrigues de |
| author_role |
author |
| author2 |
Nascimento, Ramon Campos Oliveira, Sheilla Andrade de Vasconcelos, Juliana Fraga Kaneto, Carla Martins Carvalho, Lian Felipe Paiva Pontes de Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Freitas, Luiz Antônio Rodrigues de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Bruno Solano de Freitas Nascimento, Ramon Campos Oliveira, Sheilla Andrade de Vasconcelos, Juliana Fraga Kaneto, Carla Martins Carvalho, Lian Felipe Paiva Pontes de Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Freitas, Luiz Antônio Rodrigues de Souza, Bruno Solano de Freitas Nascimento, Ramon Campos Oliveira, Sheilla Andrade de Vasconcelos, Juliana Fraga Kaneto, Carla Martins Carvalho, Lian Felipe Paiva Pontes de Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Freitas, Luiz Antônio Rodrigues de |
| dc.subject.por.fl_str_mv |
Acetaminophen Acute liver failure Bone marrow mononuclear cells Brain edema Cell therapy Tumor necrosis factor |
| topic |
Acetaminophen Acute liver failure Bone marrow mononuclear cells Brain edema Cell therapy Tumor necrosis factor |
| description |
Texto completo: acesso restrito. p. 1011–1021 |
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2012 |
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2012 |
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2014-10-09T15:45:53Z |
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1465-3249 |
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v. 14, n. 8 |
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1465-3249 v. 14, n. 8 |
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