Model of induction of thyroid dysfunctions in adult female mice

Detalhes bibliográficos
Autor(a) principal: Ferreira, E.
Data de Publicação: 2007
Outros Autores: Lima, Alessandra Estrela da Silva, Serakides, R., Gomes, A. S., Cassali, Geovanni Dantas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5349
Resumo: It is described the elaboration of a protocol to induce hyperthyroidism and hypothyroidism in mice by administrating thyroxin and propylthiouracil, respectively, in the drinking water. The drugs were administered to adult female mice of the Swiss strain for 30 days in order to obtain a systemic status of thyroid dysfunction. The induction of hyperthyroidism and hypothyroidism in the animals was confirmed by the histomorphological analysis of the thyroid in the end of the experiment, when the state of gland dysfunction in the animals submitted to the treatment was observed.
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spelling Ferreira, E.Lima, Alessandra Estrela da SilvaSerakides, R.Gomes, A. S.Cassali, Geovanni DantasFerreira, E.Lima, Alessandra Estrela da SilvaSerakides, R.Gomes, A. S.Cassali, Geovanni Dantas2012-02-08T21:39:39Z2012-02-08T21:39:39Z20070102-0935http://www.repositorio.ufba.br/ri/handle/ri/5349v. 59, n. 5It is described the elaboration of a protocol to induce hyperthyroidism and hypothyroidism in mice by administrating thyroxin and propylthiouracil, respectively, in the drinking water. The drugs were administered to adult female mice of the Swiss strain for 30 days in order to obtain a systemic status of thyroid dysfunction. The induction of hyperthyroidism and hypothyroidism in the animals was confirmed by the histomorphological analysis of the thyroid in the end of the experiment, when the state of gland dysfunction in the animals submitted to the treatment was observed.Submitted by Alessandra Estrela-Lima (aestrela@ufba.br) on 2012-02-08T21:39:39Z No. of bitstreams: 1 a22v59n5.pdf: 795018 bytes, checksum: 7429ccc221f10d21b0135ce1e811ce4b (MD5)Made available in DSpace on 2012-02-08T21:39:39Z (GMT). No. of bitstreams: 1 a22v59n5.pdf: 795018 bytes, checksum: 7429ccc221f10d21b0135ce1e811ce4b (MD5) Previous issue date: 2007-10http://www.scielo.br/pdf/abmvz/v59n5/a22v59n5.pdfreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAmousethyroidprotocolinductionthyroxinpropylthiouracilModel of induction of thyroid dysfunctions in adult female miceArq. Bras. Med. Vet. Zootecinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALa22v59n5.pdfa22v59n5.pdfapplication/pdf795018https://repositorio.ufba.br/bitstream/ri/5349/1/a22v59n5.pdf7429ccc221f10d21b0135ce1e811ce4bMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5349/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTa22v59n5.pdf.txta22v59n5.pdf.txtExtracted texttext/plain16184https://repositorio.ufba.br/bitstream/ri/5349/3/a22v59n5.pdf.txt1c6c1e2ec40672bce184c10563d7f866MD53ri/53492022-10-04 13:37:19.955oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-10-04T16:37:19Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Model of induction of thyroid dysfunctions in adult female mice
dc.title.alternative.pt_BR.fl_str_mv Arq. Bras. Med. Vet. Zootec
title Model of induction of thyroid dysfunctions in adult female mice
spellingShingle Model of induction of thyroid dysfunctions in adult female mice
Ferreira, E.
mouse
thyroid
protocol
induction
thyroxin
propylthiouracil
title_short Model of induction of thyroid dysfunctions in adult female mice
title_full Model of induction of thyroid dysfunctions in adult female mice
title_fullStr Model of induction of thyroid dysfunctions in adult female mice
title_full_unstemmed Model of induction of thyroid dysfunctions in adult female mice
title_sort Model of induction of thyroid dysfunctions in adult female mice
author Ferreira, E.
author_facet Ferreira, E.
Lima, Alessandra Estrela da Silva
Serakides, R.
Gomes, A. S.
Cassali, Geovanni Dantas
author_role author
author2 Lima, Alessandra Estrela da Silva
Serakides, R.
Gomes, A. S.
Cassali, Geovanni Dantas
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, E.
Lima, Alessandra Estrela da Silva
Serakides, R.
Gomes, A. S.
Cassali, Geovanni Dantas
Ferreira, E.
Lima, Alessandra Estrela da Silva
Serakides, R.
Gomes, A. S.
Cassali, Geovanni Dantas
dc.subject.por.fl_str_mv mouse
thyroid
protocol
induction
thyroxin
propylthiouracil
topic mouse
thyroid
protocol
induction
thyroxin
propylthiouracil
description It is described the elaboration of a protocol to induce hyperthyroidism and hypothyroidism in mice by administrating thyroxin and propylthiouracil, respectively, in the drinking water. The drugs were administered to adult female mice of the Swiss strain for 30 days in order to obtain a systemic status of thyroid dysfunction. The induction of hyperthyroidism and hypothyroidism in the animals was confirmed by the histomorphological analysis of the thyroid in the end of the experiment, when the state of gland dysfunction in the animals submitted to the treatment was observed.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2012-02-08T21:39:39Z
dc.date.available.fl_str_mv 2012-02-08T21:39:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5349
dc.identifier.issn.none.fl_str_mv 0102-0935
dc.identifier.number.pt_BR.fl_str_mv v. 59, n. 5
identifier_str_mv 0102-0935
v. 59, n. 5
url http://www.repositorio.ufba.br/ri/handle/ri/5349
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://www.scielo.br/pdf/abmvz/v59n5/a22v59n5.pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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