Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2003 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/16651 |
Resumo: | Texto completo: acesso restrito. p. 536-542 |
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Alcântara, Luiz Carlos JúniorVan Dooren, S.Gonçalves, M. S.Kashima, SimoneCosta, Maria Cristina RamosSantos, Fred Luciano NevesBittencourt, Achilea Candida LisboaDourado, Maria Inês CostaAndrade Filho, AntonioCovas, Dimas TadeuVandamme, Anne MiekeCastro, Bernardo GalvãoAlcântara, Luiz Carlos JúniorVan Dooren, S.Gonçalves, M. S.Kashima, SimoneCosta, Maria Cristina RamosSantos, Fred Luciano NevesBittencourt, Achilea Candida LisboaDourado, Maria Inês CostaAndrade Filho, AntonioCovas, Dimas TadeuVandamme, Anne MiekeCastro, Bernardo Galvão2014-11-24T15:30:48Z20031525-4135http://repositorio.ufba.br/ri/handle/ri/16651v. 33, n. 4Texto completo: acesso restrito. p. 536-542The city of Salvador, Bahia, Brazil, has sociodemographic characteristics similar to some African cities. Up to now, it has had the highest prevalence of human T-cell lymphotropic virus type I (HTLV-I) infection (1.74%) in the country. To investigate which strains of HTLV-I are circulating in Salvador, we studied isolates from 82 patients infected with HTLV-I: 19 from the general population, 21 from pregnant women, 16 from intravenous drug users, and 26 from patients and their family attending a neurologic clinic. Phylogenetic analysis from part of the LTR fragments showed that most of these isolates belonged to the Transcontinental subgroup of the Cosmopolitan subtype (HTLV-Ia). Only one sample from a pregnant woman was closely related to the Japanese subgroup, suggesting recent introduction of a Japanese HTLV-I lineage into Salvador. βA-Globin haplotypes were examined in 34 infected individuals and found to be atypical, confirming the racial heterogeneity of this population. A total of 20 chromosomes were characterized as Central African Republic (CAR) haplotype (29.4%), 31 (45.6%) were characterized as Benin (BEN) haplotype, and 17 (25%) were characterized as Senegal (SEN) haplotype. Five patients' genotypes (14.7%) were CAR/CAR; 10 (29,4%), BEN/BEN; 9 (26.5%), CAR/BEN; 2 (5.9%), BEN/SEN; and 7 (20.6%), SEN/SEN. One patient's genotype (2.9%) was CAR/SEN. The βA-globin haplotype distribution in Salvador is unusual compared with other Brazilian states. Our data support the hypothesis of multiple post-Columbian introductions of African HTLV-Ia strains in Salvador, Bahia, Brazil.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-12-16T14:25:31Z No. of bitstreams: 1 Alcantara Jr., L.C..pdf: 4754821 bytes, checksum: 3db17ce104d62660d53fa3a93f69e4e1 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-11-24T15:30:48Z (GMT) No. of bitstreams: 1 Alcantara Jr., L.C..pdf: 4754821 bytes, checksum: 3db17ce104d62660d53fa3a93f69e4e1 (MD5)Made available in DSpace on 2014-11-24T15:30:48Z (GMT). No. of bitstreams: 1 Alcantara Jr., L.C..pdf: 4754821 bytes, checksum: 3db17ce104d62660d53fa3a93f69e4e1 (MD5) Previous issue date: 2003β-globin haplotypesBantuHTLV-ILTRSalvador-BrazilSouthern AfricaGlobin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virusJAIDS Journal of Acquired Immune Deficiency Syndromesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAORIGINALAlcantara Jr., L.C..pdfAlcantara Jr., L.C..pdfapplication/pdf4754821https://repositorio.ufba.br/bitstream/ri/16651/1/Alcantara%20Jr.%2c%20L.C..pdf3db17ce104d62660d53fa3a93f69e4e1MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16651/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTAlcantara Jr., L.C..pdf.txtAlcantara Jr., L.C..pdf.txtExtracted texttext/plain7https://repositorio.ufba.br/bitstream/ri/16651/3/Alcantara%20Jr.%2c%20L.C..pdf.txt212b0306580d4f0044d18f9a3edcc832MD53ri/166512022-08-26 11:02:27.694oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-26T14:02:27Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus |
| dc.title.alternative.pt_BR.fl_str_mv |
JAIDS Journal of Acquired Immune Deficiency Syndromes |
| title |
Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus |
| spellingShingle |
Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus Alcântara, Luiz Carlos Júnior β-globin haplotypes Bantu HTLV-I LTR Salvador-Brazil Southern Africa |
| title_short |
Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus |
| title_full |
Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus |
| title_fullStr |
Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus |
| title_full_unstemmed |
Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus |
| title_sort |
Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus |
| author |
Alcântara, Luiz Carlos Júnior |
| author_facet |
Alcântara, Luiz Carlos Júnior Van Dooren, S. Gonçalves, M. S. Kashima, Simone Costa, Maria Cristina Ramos Santos, Fred Luciano Neves Bittencourt, Achilea Candida Lisboa Dourado, Maria Inês Costa Andrade Filho, Antonio Covas, Dimas Tadeu Vandamme, Anne Mieke Castro, Bernardo Galvão |
| author_role |
author |
| author2 |
Van Dooren, S. Gonçalves, M. S. Kashima, Simone Costa, Maria Cristina Ramos Santos, Fred Luciano Neves Bittencourt, Achilea Candida Lisboa Dourado, Maria Inês Costa Andrade Filho, Antonio Covas, Dimas Tadeu Vandamme, Anne Mieke Castro, Bernardo Galvão |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Alcântara, Luiz Carlos Júnior Van Dooren, S. Gonçalves, M. S. Kashima, Simone Costa, Maria Cristina Ramos Santos, Fred Luciano Neves Bittencourt, Achilea Candida Lisboa Dourado, Maria Inês Costa Andrade Filho, Antonio Covas, Dimas Tadeu Vandamme, Anne Mieke Castro, Bernardo Galvão Alcântara, Luiz Carlos Júnior Van Dooren, S. Gonçalves, M. S. Kashima, Simone Costa, Maria Cristina Ramos Santos, Fred Luciano Neves Bittencourt, Achilea Candida Lisboa Dourado, Maria Inês Costa Andrade Filho, Antonio Covas, Dimas Tadeu Vandamme, Anne Mieke Castro, Bernardo Galvão |
| dc.subject.por.fl_str_mv |
β-globin haplotypes Bantu HTLV-I LTR Salvador-Brazil Southern Africa |
| topic |
β-globin haplotypes Bantu HTLV-I LTR Salvador-Brazil Southern Africa |
| description |
Texto completo: acesso restrito. p. 536-542 |
| publishDate |
2003 |
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2003 |
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2014-11-24T15:30:48Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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1525-4135 |
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v. 33, n. 4 |
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1525-4135 v. 33, n. 4 |
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http://repositorio.ufba.br/ri/handle/ri/16651 |
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