Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil

Detalhes bibliográficos
Autor(a) principal: Castellucci, Léa
Data de Publicação: 2012
Outros Autores: Jamieson, Sarra E., Almeida, Lucas, Oliveira, Joyce, Guimarães, Luiz Henrique, Lessa, Marcus, Fakiola, Michaela, Jesus, Amélia Ribeiro de, Miller, E. Nancy, Carvalho Filho, Edgar Marcelino de, Blackwell, Jenefer M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16216
Resumo: Texto completo: acesso restrito. p. 1102–1110
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spelling Castellucci, LéaJamieson, Sarra E.Almeida, LucasOliveira, JoyceGuimarães, Luiz HenriqueLessa, MarcusFakiola, MichaelaJesus, Amélia Ribeiro deMiller, E. NancyCarvalho Filho, Edgar Marcelino deBlackwell, Jenefer M.Castellucci, LéaJamieson, Sarra E.Almeida, LucasOliveira, JoyceGuimarães, Luiz HenriqueLessa, MarcusFakiola, MichaelaJesus, Amélia Ribeiro deMiller, E. NancyCarvalho Filho, Edgar Marcelino deBlackwell, Jenefer M.2014-10-01T14:09:08Z20121567-1348http://repositorio.ufba.br/ri/handle/ri/16216v. 12, n. 5Texto completo: acesso restrito. p. 1102–1110Leishmania braziliensis causes cutaneous (CL) and mucosal (ML) leishmaniasis. In the mouse, Fli1 was identified as a gene influencing enhanced wound healing and resistance to CL caused by Leishmania major. Polymorphism at FLI1 is associated with CL caused by L. braziliensis in humans, with an inverse association observed for ML disease. Here we extend the analysis to look at other wound healing genes, including CTGF, TGFB1, TGFBR1/2, SMADS 2/3/4/7 and FLII, all functionally linked along with FLI1 in the TGF beta pathway. Haplotype tagging single nucleotide polymorphisms (tag-SNPs) were genotyped using Taqman technology in 325 nuclear families (652 CL cases; 126 ML cases) from Brazil. Robust case-pseudocontrol (CPC) conditional logistic regression analysis showed associations between CL and SNPs at CTGF (SNP rs6918698; CC genotype; OR 1.67; 95%CI 1.10–2.54; P = 0.016), TGFBR2 (rs1962859; OR 1.50; 95%CI 1.12–1.99; P = 0.005), SMAD2 (rs1792658; OR 1.57; 95%CI 1.04–2.38; P = 0.03), SMAD7 (rs4464148; AA genotype; OR 2.80; 95%CI 1.00–7.87; P = 0.05) and FLII (rs2071242; OR 1.60; 95%CI 1.14–2.24; P = 0.005), and between ML and SNPs at SMAD3 (rs1465841; OR 2.15; 95%CI 1.13–4.07; P = 0.018) and SMAD7 (rs2337107; TT genotype; OR 3.70; 95%CI 1.27–10.7; P = 0.016). Stepwise logistic regression analysis showed that all SNPs associated with CL at FLI1, CTGF, TGFBR2, and FLII showed independent effects from each other, but SNPs at SMAD2 and SMAD7 did not add independent effects to SNPs from other genes. These results suggest that TGFβ signalling via SMAD2 is important in directing events that contribute to CL, whereas signalling via SMAD3 is important in ML. Both are modulated by the inhibitory SMAD7 that acts upstream of SMAD2 and SMAD3 in this signalling pathway. Along with the published FLI1 association, these data further contribute to the hypothesis that wound healing processes are important determinants of pathology associated with cutaneous forms of leishmaniasis.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-04T12:21:24Z No. of bitstreams: 1 Léa Castellucci.pdf: 550337 bytes, checksum: 7948a8cfa94eac5bb95915e5d18b449d (MD5)Rejected by Delba Rosa (delba@ufba.br), reason: Por gentileza, coloque os autores na ordem on 2014-09-29T15:34:23Z (GMT)Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-10-01T13:03:27Z No. of bitstreams: 1 Léa Castellucci.pdf: 550337 bytes, checksum: 7948a8cfa94eac5bb95915e5d18b449d (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-10-01T14:09:08Z (GMT) No. of bitstreams: 1 Léa Castellucci.pdf: 550337 bytes, checksum: 7948a8cfa94eac5bb95915e5d18b449d (MD5)Made available in DSpace on 2014-10-01T14:09:08Z (GMT). No. of bitstreams: 1 Léa Castellucci.pdf: 550337 bytes, checksum: 7948a8cfa94eac5bb95915e5d18b449d (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1016/j.meegid.2012.03.017reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmaniasisWound healingTGFB pathwayCTGFSMADsFLIIWound healing genes and susceptibility to cutaneous leishmaniasis in BrazilInfection, Genetics and Evolutioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16216/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINALLéa Castellucci.pdfLéa Castellucci.pdfapplication/pdf550337https://repositorio.ufba.br/bitstream/ri/16216/1/L%c3%a9a%20Castellucci.pdf7948a8cfa94eac5bb95915e5d18b449dMD51TEXTLéa Castellucci.pdf.txtLéa Castellucci.pdf.txtExtracted texttext/plain50540https://repositorio.ufba.br/bitstream/ri/16216/3/L%c3%a9a%20Castellucci.pdf.txtc4ba1ba2e451f717fadbca7e37d31fc9MD53ri/162162022-07-05 14:03:33.224oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:33Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil
dc.title.alternative.pt_BR.fl_str_mv Infection, Genetics and Evolution
title Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil
spellingShingle Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil
Castellucci, Léa
Leishmaniasis
Wound healing
TGFB pathway
CTGF
SMADs
FLII
title_short Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil
title_full Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil
title_fullStr Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil
title_full_unstemmed Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil
title_sort Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil
author Castellucci, Léa
author_facet Castellucci, Léa
Jamieson, Sarra E.
Almeida, Lucas
Oliveira, Joyce
Guimarães, Luiz Henrique
Lessa, Marcus
Fakiola, Michaela
Jesus, Amélia Ribeiro de
Miller, E. Nancy
Carvalho Filho, Edgar Marcelino de
Blackwell, Jenefer M.
author_role author
author2 Jamieson, Sarra E.
Almeida, Lucas
Oliveira, Joyce
Guimarães, Luiz Henrique
Lessa, Marcus
Fakiola, Michaela
Jesus, Amélia Ribeiro de
Miller, E. Nancy
Carvalho Filho, Edgar Marcelino de
Blackwell, Jenefer M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castellucci, Léa
Jamieson, Sarra E.
Almeida, Lucas
Oliveira, Joyce
Guimarães, Luiz Henrique
Lessa, Marcus
Fakiola, Michaela
Jesus, Amélia Ribeiro de
Miller, E. Nancy
Carvalho Filho, Edgar Marcelino de
Blackwell, Jenefer M.
Castellucci, Léa
Jamieson, Sarra E.
Almeida, Lucas
Oliveira, Joyce
Guimarães, Luiz Henrique
Lessa, Marcus
Fakiola, Michaela
Jesus, Amélia Ribeiro de
Miller, E. Nancy
Carvalho Filho, Edgar Marcelino de
Blackwell, Jenefer M.
dc.subject.por.fl_str_mv Leishmaniasis
Wound healing
TGFB pathway
CTGF
SMADs
FLII
topic Leishmaniasis
Wound healing
TGFB pathway
CTGF
SMADs
FLII
description Texto completo: acesso restrito. p. 1102–1110
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-10-01T14:09:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16216
dc.identifier.issn.none.fl_str_mv 1567-1348
dc.identifier.number.pt_BR.fl_str_mv v. 12, n. 5
identifier_str_mv 1567-1348
v. 12, n. 5
url http://repositorio.ufba.br/ri/handle/ri/16216
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1016/j.meegid.2012.03.017
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