Antibodies to citrullinated peptides in tuberculosis

Detalhes bibliográficos
Autor(a) principal: Lima, I.
Data de Publicação: 2013
Outros Autores: Oliveira, R. C., Atta, Ajax Mercês, Marchi, S., Barbosa, L., Reis, E., Reis, M. G., Santiago, Mittermayer Barreto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13764
Resumo: p. 685-687
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spelling Lima, I.Oliveira, R. C.Atta, Ajax MercêsMarchi, S.Barbosa, L.Reis, E.Reis, M. G.Santiago, Mittermayer BarretoLima, I.Oliveira, R. C.Atta, Ajax MercêsMarchi, S.Barbosa, L.Reis, E.Reis, M. G.Santiago, Mittermayer Barreto2013-11-19T20:13:38Z20130770-3198http://repositorio.ufba.br/ri/handle/ri/13764v. 32, n. 5p. 685-687Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetric polyarthritis, rheumatoid factor (RF) positivity, and bone erosions. Recently, research has been conducted on anti-citrullinated peptide antibodies (ACPAs) to which there are greater sensitivity and specificity than RF. However, these antibodies have also been described in infectious diseases, particularly tuberculosis (TB), placing the high specificity of the test in doubt. The aim of this research was to study the prevalence of ACPAs in TB, RA, and healthy controls. Patients with bacteriologically confirmed pulmonary tuberculosis, RA (ACR criteria), in addition to healthy controls were included. ACPAs were researched by: anti-cyclic citrullinated peptide (CCP), anti-modified citrullinated vimentin (MCV), and RF by ELISA. The study was conducted in 50 TB patients, 50 with RA, and 20 controls. Anti-CCP antibodies were found in 39 (78 %) of the RA patients (median titer, 128 U), whereas anti- MCV antibodies were found in 25 (50 %). Of the patients with TB, two (4 %) had positivity for anti- CCP and anti-MCV and no patient in the control group tested positive for these antibodies. Sensitivity of anti- CCP for RA was 78 % (confidence interval (CI), 63 to 88 %) and specificity was 97 % (CI, 89 to 99 %) while the sensitivity of anti-MCV was 50 % (CI, 35–64 %) and specificity was 97 % (CI, 89 to 99 %). RF was positive in 40 samples (80 %) of RA, in 30 (60 %) of TB, and in 1 (5 %) of the controls. Our findings showed high sensitivity of anti-CCP and high specificity of both anti-CCP and anti-MCV antibodies for RA, even in a population with high incidence of tuberculosis. The higher frequency of positivity of ACPA in TB observed in previous studies may be attributed to methodological factors.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-11-19T18:12:03Z No. of bitstreams: 1 111111a.pdf: 93234 bytes, checksum: 3bc5103681fdb9d6bef0ac8b797d712a (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-19T20:13:38Z (GMT) No. of bitstreams: 1 111111a.pdf: 93234 bytes, checksum: 3bc5103681fdb9d6bef0ac8b797d712a (MD5)Made available in DSpace on 2013-11-19T20:13:38Z (GMT). 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dc.title.pt_BR.fl_str_mv Antibodies to citrullinated peptides in tuberculosis
dc.title.alternative.pt_BR.fl_str_mv Clinical Rheumatology
title Antibodies to citrullinated peptides in tuberculosis
spellingShingle Antibodies to citrullinated peptides in tuberculosis
Lima, I.
ACPA
Anti-CCP
Anti-MCV
Rheumatoid arthritis
Rheumatoid factor
Tuberculosis
title_short Antibodies to citrullinated peptides in tuberculosis
title_full Antibodies to citrullinated peptides in tuberculosis
title_fullStr Antibodies to citrullinated peptides in tuberculosis
title_full_unstemmed Antibodies to citrullinated peptides in tuberculosis
title_sort Antibodies to citrullinated peptides in tuberculosis
author Lima, I.
author_facet Lima, I.
Oliveira, R. C.
Atta, Ajax Mercês
Marchi, S.
Barbosa, L.
Reis, E.
Reis, M. G.
Santiago, Mittermayer Barreto
author_role author
author2 Oliveira, R. C.
Atta, Ajax Mercês
Marchi, S.
Barbosa, L.
Reis, E.
Reis, M. G.
Santiago, Mittermayer Barreto
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, I.
Oliveira, R. C.
Atta, Ajax Mercês
Marchi, S.
Barbosa, L.
Reis, E.
Reis, M. G.
Santiago, Mittermayer Barreto
Lima, I.
Oliveira, R. C.
Atta, Ajax Mercês
Marchi, S.
Barbosa, L.
Reis, E.
Reis, M. G.
Santiago, Mittermayer Barreto
dc.subject.por.fl_str_mv ACPA
Anti-CCP
Anti-MCV
Rheumatoid arthritis
Rheumatoid factor
Tuberculosis
topic ACPA
Anti-CCP
Anti-MCV
Rheumatoid arthritis
Rheumatoid factor
Tuberculosis
description p. 685-687
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-11-19T20:13:38Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13764
dc.identifier.issn.none.fl_str_mv 0770-3198
dc.identifier.number.pt_BR.fl_str_mv v. 32, n. 5
identifier_str_mv 0770-3198
v. 32, n. 5
url http://repositorio.ufba.br/ri/handle/ri/13764
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Clinical Rheumatology
publisher.none.fl_str_mv Clinical Rheumatology
dc.source.pt_BR.fl_str_mv http://download.springer.com/static/pdf/996/art%253A10.1007%252Fs10067-013-2173-y.pdf?auth66=1385057075_02d34faf15bf1d6cfba013499c3900e0&ext=.pdf
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