Polymorphism of Cytokine Genes (TGF-[beta]1, IFN-[gamma], IL-6, IL-10, and TNF-[alpha]) in Patients With Chronic Pancreatitis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13897 |
Resumo: | Texto completo: acesso restrito. p. 333-336 |
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Bendicho, Maria Teresita Del Niño Jesus FernandezGuedes, Jorge CarvalhoSilva, Naize Nara Pinheiro daSantana, Genoile OliveiraSantos, Raquel Rocha dosLyra, André CastroLyra, Luiz Guilherme CostaNascimento, Roberto José MeyerLemaire, Denise CarneiroBendicho, Maria Teresita Del Niño Jesus FernandezGuedes, Jorge CarvalhoSilva, Naize Nara Pinheiro daSantana, Genoile OliveiraSantos, Raquel Rocha dosLyra, André CastroLyra, Luiz Guilherme CostaNascimento, Roberto José MeyerLemaire, Denise Carneiro2013-11-26T13:00:47Z20050885-3177http://repositorio.ufba.br/ri/handle/ri/13897v. 30, n. 4Texto completo: acesso restrito. p. 333-336Objectives: The polymorphisms in cytokine genes have allowed for the understanding of the genetic determinants of diseases. The aims of this study were to describe and compare the frequencies of polymorphisms on the interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-[alpha], transforming growth factor (TGF)-[beta]1, and interferon (IFN)-[gamma] genes between patients with chronic pancreatitis (CP) and healthy individuals from Bahia, Brazil. Methods: Twenty-eight individuals were evaluated at a university gastroenterology outpatient service (4 women and 24 men), all diagnosed with CP based on clinical and radiologic aspects. The control group was composed of 94 (11 women and 83 men) blood donors. The polymorphisms studied were TNF-[alpha] (-308G/A), TGF-[beta]1 (codon 10C/T, codon 25C/G), IL-10 (-1082A/G; -819T/C; -592A/C), IL-6 (-174G/C), and IFN-[gamma] (+874T/A). Results: A statistically significant difference was observed in the frequency of the polymorphisms between the group of patients with CP and the group of healthy individuals with the polymorphism of the TGF-[beta]1 gene on codon 10. No statistically significant differences were found for the allele and genotypic frequencies on the genes that code TNF-[alpha], IFN-[gamma], IL-10, and TGF-[beta]1 codon 25, and IL-6 between the control and case groups. Conclusion: The genotypes corresponding to the high TGF-[beta]1 producer phenotypes can be associated with the fibrogenesis shown with CP.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-11-26T12:40:26Z No. of bitstreams: 1 Bendicho, Maria Teresita.pdf: 80876 bytes, checksum: cbcd188061e770e70be4f5523bbd75eb (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-26T13:00:47Z (GMT) No. of bitstreams: 1 Bendicho, Maria Teresita.pdf: 80876 bytes, checksum: cbcd188061e770e70be4f5523bbd75eb (MD5)Made available in DSpace on 2013-11-26T13:00:47Z (GMT). No. of bitstreams: 1 Bendicho, Maria Teresita.pdf: 80876 bytes, checksum: cbcd188061e770e70be4f5523bbd75eb (MD5) Previous issue date: 2005ChronicPancreatitisCytokinesGenetic polymorphismTransforming growth factor-b1Polymorphism of Cytokine Genes (TGF-[beta]1, IFN-[gamma], IL-6, IL-10, and TNF-[alpha]) in Patients With Chronic PancreatitisPancreasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAORIGINALBendicho, Maria Teresita.pdfBendicho, Maria Teresita.pdfapplication/pdf80876https://repositorio.ufba.br/bitstream/ri/13897/1/Bendicho%2c%20Maria%20Teresita.pdfcbcd188061e770e70be4f5523bbd75ebMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13897/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTBendicho, Maria Teresita.pdf.txtBendicho, Maria Teresita.pdf.txtExtracted texttext/plain22330https://repositorio.ufba.br/bitstream/ri/13897/3/Bendicho%2c%20Maria%20Teresita.pdf.txt91c98c92706be1ec2ef2da31fc6650b6MD53ri/138972022-07-05 14:03:29.893oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:29Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Polymorphism of Cytokine Genes (TGF-[beta]1, IFN-[gamma], IL-6, IL-10, and TNF-[alpha]) in Patients With Chronic Pancreatitis |
| dc.title.alternative.pt_BR.fl_str_mv |
Pancreas |
| title |
Polymorphism of Cytokine Genes (TGF-[beta]1, IFN-[gamma], IL-6, IL-10, and TNF-[alpha]) in Patients With Chronic Pancreatitis |
| spellingShingle |
Polymorphism of Cytokine Genes (TGF-[beta]1, IFN-[gamma], IL-6, IL-10, and TNF-[alpha]) in Patients With Chronic Pancreatitis Bendicho, Maria Teresita Del Niño Jesus Fernandez Chronic Pancreatitis Cytokines Genetic polymorphism Transforming growth factor-b1 |
| title_short |
Polymorphism of Cytokine Genes (TGF-[beta]1, IFN-[gamma], IL-6, IL-10, and TNF-[alpha]) in Patients With Chronic Pancreatitis |
| title_full |
Polymorphism of Cytokine Genes (TGF-[beta]1, IFN-[gamma], IL-6, IL-10, and TNF-[alpha]) in Patients With Chronic Pancreatitis |
| title_fullStr |
Polymorphism of Cytokine Genes (TGF-[beta]1, IFN-[gamma], IL-6, IL-10, and TNF-[alpha]) in Patients With Chronic Pancreatitis |
| title_full_unstemmed |
Polymorphism of Cytokine Genes (TGF-[beta]1, IFN-[gamma], IL-6, IL-10, and TNF-[alpha]) in Patients With Chronic Pancreatitis |
| title_sort |
Polymorphism of Cytokine Genes (TGF-[beta]1, IFN-[gamma], IL-6, IL-10, and TNF-[alpha]) in Patients With Chronic Pancreatitis |
| author |
Bendicho, Maria Teresita Del Niño Jesus Fernandez |
| author_facet |
Bendicho, Maria Teresita Del Niño Jesus Fernandez Guedes, Jorge Carvalho Silva, Naize Nara Pinheiro da Santana, Genoile Oliveira Santos, Raquel Rocha dos Lyra, André Castro Lyra, Luiz Guilherme Costa Nascimento, Roberto José Meyer Lemaire, Denise Carneiro |
| author_role |
author |
| author2 |
Guedes, Jorge Carvalho Silva, Naize Nara Pinheiro da Santana, Genoile Oliveira Santos, Raquel Rocha dos Lyra, André Castro Lyra, Luiz Guilherme Costa Nascimento, Roberto José Meyer Lemaire, Denise Carneiro |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bendicho, Maria Teresita Del Niño Jesus Fernandez Guedes, Jorge Carvalho Silva, Naize Nara Pinheiro da Santana, Genoile Oliveira Santos, Raquel Rocha dos Lyra, André Castro Lyra, Luiz Guilherme Costa Nascimento, Roberto José Meyer Lemaire, Denise Carneiro Bendicho, Maria Teresita Del Niño Jesus Fernandez Guedes, Jorge Carvalho Silva, Naize Nara Pinheiro da Santana, Genoile Oliveira Santos, Raquel Rocha dos Lyra, André Castro Lyra, Luiz Guilherme Costa Nascimento, Roberto José Meyer Lemaire, Denise Carneiro |
| dc.subject.por.fl_str_mv |
Chronic Pancreatitis Cytokines Genetic polymorphism Transforming growth factor-b1 |
| topic |
Chronic Pancreatitis Cytokines Genetic polymorphism Transforming growth factor-b1 |
| description |
Texto completo: acesso restrito. p. 333-336 |
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2005 |
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2005 |
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2013-11-26T13:00:47Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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0885-3177 |
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v. 30, n. 4 |
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0885-3177 v. 30, n. 4 |
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http://repositorio.ufba.br/ri/handle/ri/13897 |
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